{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:02:23Z","timestamp":1781766143349,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The purpose of this study was to retrospectively compare efficacy and safety between intradiscal injection of a gelified ethanol product and tubular discectomy in the treatment of intervertebral disk herniation. A bi-central institutional database research identified forty (40) patients suffering from symptomatic contained disc herniation. Nucleolysis Group included 20 patients [mean 50.05 \u00b1 9.27 years-of-age (male\/female 14\/6\u201370\/30%)] and Surgery Group included 20 patients [mean 48.45 \u00b1 14.53 years-of-age, (male\/female 12\/8\u201360\/40%)]. Primary outcome was overall 12-month improvement over baseline in leg pain (NVS units). Procedural technical outcomes were recorded, and adverse events were evaluated at all follow-up intervals. CIRSE classification system was used for complications\u2019 reporting. Mean pre-operative pain score in Nucleolysis Group was 7.95 \u00b1 0.94 reduced to 1.25 \u00b1 1.11 at month 1 and 0.45 \u00b1 0.75 NVS units at year 1. Mean pre-operative pain score in Surgery Group was 7.65 \u00b1 1.13 reduced to 1.55 \u00b1 1.79 at month 1 and 0.70 \u00b1 1.38 NVS units at year 1. Pain decrease was statistically significant after both procedures (p &lt; 0.001). There was no statistically significant difference between pain reduction in both groups (p = 0.347). The decrease differences of the pain effect upon general activities, sleeping, socializing, walking, and enjoying life in the follow-up period between the two groups were not statistically significant. No complications were noted in both groups. Results from the current study report that intradiscal injection of a gelified ethanol and tubular discectomy were equally effective on terms of efficacy and safety for the treatment of symptomatic lumbar intervertebral disc herniation regarding the 12-month mean leg pain improvement. Both achieved similar rapid significant clinical improvement persisting throughout follow-up period.<\/jats:p>","DOI":"10.3390\/diagnostics13132164","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T02:40:23Z","timestamp":1687747223000},"page":"2164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intradiscal Gelified Ethanol Nucleolysis versus Endoscopic Surgery for Lumbar Disc Herniation Radiculopathy"],"prefix":"10.3390","volume":"13","author":[{"given":"Christos","family":"Gogos","sequence":"first","affiliation":[{"name":"Neurosurgery Clinic, General Hospital \u201cAsklepieio\u201d, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-7464","authenticated-orcid":false,"given":"Dimitrios K.","family":"Filippiadis","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-284X","authenticated-orcid":false,"given":"Georgios","family":"Velonakis","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kelekis","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Papagelopoulos","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery & Traumatology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-6041","authenticated-orcid":false,"given":"Alexis","family":"Kelekis","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/00007632-199405310-00002","article-title":"Low back pain hospitalization. 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