{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:26:27Z","timestamp":1779333987141,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Fund for Guangdong Provincial high-level Clinical Key Specialties","award":["SZGSP009"],"award-info":[{"award-number":["SZGSP009"]}]},{"name":"Shenzhen Fund for Guangdong Provincial high-level Clinical Key Specialties","award":["SZSM201612045"],"award-info":[{"award-number":["SZSM201612045"]}]},{"name":"Shenzhen Fund for Guangdong Provincial high-level Clinical Key Specialties","award":["JCYJ20190809170009528"],"award-info":[{"award-number":["JCYJ20190809170009528"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZGSP009"],"award-info":[{"award-number":["SZGSP009"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201612045"],"award-info":[{"award-number":["SZSM201612045"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["JCYJ20190809170009528"],"award-info":[{"award-number":["JCYJ20190809170009528"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Science and Technology Program","award":["SZGSP009"],"award-info":[{"award-number":["SZGSP009"]}]},{"name":"Shenzhen Science and Technology Program","award":["SZSM201612045"],"award-info":[{"award-number":["SZSM201612045"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20190809170009528"],"award-info":[{"award-number":["JCYJ20190809170009528"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Lung ultrasound (LU) is increasingly used to diagnose and monitor neonatal pulmonary disorders; however, its role in hemodynamically significant patent ductus arteriosus (hsPDA) has not been elucidated. This prospective study investigated the predictive value of the LU score (LUS) for hsPDA in preterm infants with gestational age (GA) \u2264 25 weeks. Preterm infants with GA \u2264 25 weeks were enrolled in this study. LU was conducted on the fourth day of life (DOL). Six lung regions in every lung were scanned, with each region rated as 0\u20134 points. The performance of the LUS in predicting hsPDA among infants aged \u226425 weeks was analyzed by plotting the receiver operating characteristic (ROC) curve. A total of 81 infants were included in this study. GA, birth weight (BW), gender, Apgar score, delivery mode, antenatal steroids, meconium-stained amniotic fluid, premature rapture of membrane, and early-onset sepsis were not significantly different, but infants in the hsPDA group had increased LUS (38.2 \u00b1 2.8 vs. 30.3 \u00b1 4.3, p &lt; 0.001) compared with non-hsPDA group. The area under the ROC curve (AUC) value of the LUS on the fourth DOL was 0.94 (95% CI: 0.93\u20130.99) in predicting hsPDA. The LUS threshold at 33 achieved 89% sensitivity and 83% specificity, with the positive and negative predictive values (PPV and NPV) being 87 and 86%, respectively. The LUS can predict hsPDA in extremely preterm infants at an early stage.<\/jats:p>","DOI":"10.3390\/diagnostics13132263","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:37:28Z","timestamp":1688517448000},"page":"2263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Predictive Value of Lung Ultrasound Score on Hemodynamically Significant Patent Ductus Arteriosus among Neonates \u226425 Weeks"],"prefix":"10.3390","volume":"13","author":[{"given":"Haifeng","family":"Zong","sequence":"first","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingchun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongping","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanliang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanzhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F220","DOI":"10.1136\/archdischild-2017-314453","article-title":"Postnatal cardiovascular adaptation","volume":"104","author":"Gill","year":"2019","journal-title":"Arch. 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