{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:58:43Z","timestamp":1771671523141,"version":"3.50.1"},"reference-count":66,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Neonatal diabetes mellitus is a rare genetic disease that affects 1 in 90,000 live births. The start of the disease is often before the baby is 6 months old, with rare cases of onset between 6 months and 1 year. It is characterized by low or absent insulin levels in the blood, leading to severe hyperglycemia in the patient, which requires temporary insulin therapy in around 50% of cases or permanent insulin therapy in other cases. Two major processes involved in diabetes mellitus are a deformed pancreas with altered insulin-secreting cell development and\/or survival or faulty functioning of the existing pancreatic beta cell. We will discuss the cases of two preterm girls with neonatal diabetes mellitus in this research. In addition to reviewing the literature on the topic, we examined the different mutations, patient care, and clinical outcomes both before and after insulin treatment.<\/jats:p>","DOI":"10.3390\/diagnostics13132271","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:37:28Z","timestamp":1688517448000},"page":"2271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Continuous Glucose Monitoring in Transient Neonatal Diabetes Mellitus\u20142 Case Reports and Literature Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4996-2484","authenticated-orcid":false,"given":"Tatiana","family":"Chisnoiu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Luminita","family":"Balasa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5525-5408","authenticated-orcid":false,"given":"Larisia","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8147-3632","authenticated-orcid":false,"given":"Ancuta","family":"Lupu","sequence":"additional","affiliation":[{"name":"Pediatrics, \u201cGrigore T. Popa\u201d, Department of Mother and Child Medicine, University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina Elena","family":"Frecus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Ion","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Andrusca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-2814","authenticated-orcid":false,"given":"Alexandru Cosmin","family":"Pantazi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Nicolae","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-8795","authenticated-orcid":false,"given":"Vasile Valeriu","family":"Lupu","sequence":"additional","affiliation":[{"name":"Pediatrics, \u201cGrigore T. Popa\u201d, Department of Mother and Child Medicine, University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Department 1 Preclinical, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8844-0593","authenticated-orcid":false,"given":"Cristina Maria","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-8938","authenticated-orcid":false,"given":"Simona Claudia","family":"Cambrea","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of General Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1172-2-12","article-title":"Neonatal diabetes mellitus: A disease linked to multiple mechanisms","volume":"2","author":"Polak","year":"2007","journal-title":"Orphanet J. 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