{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:17:04Z","timestamp":1783365424128,"version":"3.54.6"},"reference-count":30,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["HCTRECD R25MD007607"],"award-info":[{"award-number":["HCTRECD R25MD007607"]}]},{"name":"National Institute of Health","award":["MD007579"],"award-info":[{"award-number":["MD007579"]}]},{"name":"RCMI Specialized Center for Health Disparities at PHSU","award":["HCTRECD R25MD007607"],"award-info":[{"award-number":["HCTRECD R25MD007607"]}]},{"name":"RCMI Specialized Center for Health Disparities at PHSU","award":["MD007579"],"award-info":[{"award-number":["MD007579"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder that results from the dysfunction of motile cilia, which can cause chronic upper and lower respiratory infections leading to bronchiectasis. However, there is a need for additional tools to monitor the progression of bronchiectasis in PCD. The forced oscillation technique (FOT) is an effort-independent lung function test that can be used to evaluate respiratory mechanics. In this retrospective study, we aimed to describe the radiographic findings associated with respiratory impedance (resistance (Rrs) and reactance (Xrs)) measured by FOT in six adult PCD patients and one pediatric with the (RSPH4A (c.921+3_921+6delAAGT (intronic)) founder mutation. We compared the radiographic findings on a high-resolution chest computed tomography (CT) scan with the FOT results. Our findings suggest that respiratory impedance measured by FOT may be a valuable tool for detecting and monitoring the progression of bronchiectasis in PCD patients with the (RSPH4A (c.921+3_921+6delAAGT (intronic)) founder mutation. However, further research is necessary to validate these results and determine the sensitivity and specificity of bronchiectasis monitoring in PCD patients with other genetic mutations.<\/jats:p>","DOI":"10.3390\/diagnostics13132287","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:41:27Z","timestamp":1688604087000},"page":"2287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bronchiectasis Assessment in Primary Ciliary Dyskinesia: A Non-Invasive Approach Using Forced Oscillation Technique"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-3517","authenticated-orcid":false,"given":"Wilfredo","family":"De Jes\u00fas-Rojas","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Reyes-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"San Juan Bautista School of Medicine, Caguas, PR 00725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mu\u00f1iz-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Quiles Ruiz de Porras","sequence":"additional","affiliation":[{"name":"San Juan Bautista School of Medicine, Caguas, PR 00725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-6780","authenticated-orcid":false,"given":"Jes\u00fas","family":"Mel\u00e9ndez-Monta\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos J.","family":"Ramos-Benitez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Mosquera","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","first-page":"51","article-title":"Primary Ciliary Dyskinesia (PCD): A genetic disorder of motile cilia","volume":"4","author":"Leigh","year":"2019","journal-title":"Transl. 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