{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:39:07Z","timestamp":1770226747228,"version":"3.49.0"},"reference-count":47,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The most common cause of death in patients with Duchenne muscular dystrophy (DMD) is cardiomyopathy. Our aim was to investigate the relationship between the Tpeak\u2013Tend (Tp-e) interval and the premature ventricular contraction (PVC) burden and therefore early arrhythmic risk and cardiac involvement in DMD patients. Twenty-five patients with DMD followed by pediatric cardiology were included in the study. Those with a frequency of &lt;1% PVC in the 24 h Holter were assigned to Group 1 (n = 15), and those with &gt;1% were assigned to Group 2 (n = 10). Comparisons were made with healthy controls (n = 27). Left ventricular ejection fraction (LVEF) was lowest in Group 2 and highest in the control group (p &lt; 0.001). LV end-diastolic diameter was greater in Group 2 than in Group 1 and the control group (p = 0.005). Pro-BNP and troponin levels were higher in Group 1 and Group 2 than in the control group (p = 0.001 and p &lt; 0.001, respectively). Tp-e interval was longer in Group 2 compared to Group 1 and the control group (p &lt; 0.001). The LVEF (OR 0.879, 95% CI 0.812\u20130.953; p = 0.002) and Tp-e interval (OR 1.181, 95% CI 1.047\u20131.332; p = 0.007) were independent predictors of PVC\/24 h frequency of &gt;1%. A Tp-e interval &gt; 71.65 ms predicts PVC &gt; 1%, with a sensitivity of 80% and a specificity of 90% (AUC = 0.842, 95% CI (0.663\u20131.000), p = 0.001). Determination of Tp-e prolongation from ECG data may help in the determination of cardiac involvement and early diagnosis of arrhythmic risk in DMD.<\/jats:p>","DOI":"10.3390\/diagnostics13142381","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:41:05Z","timestamp":1689554465000},"page":"2381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of Tpeak\u2013Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-0191","authenticated-orcid":false,"given":"Serra","family":"Baskan","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-5462","authenticated-orcid":false,"given":"Pelin","family":"Karaca Ozer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Orta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7103-7066","authenticated-orcid":false,"given":"Doruk","family":"Ozbingol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Ayduk Govdeli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Nisli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazim","family":"Oztarhan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34134, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1161\/CIRCULATIONAHA.114.015151","article-title":"Working Group of the National Heart, Lung, and Blood Institute; Parent Project Muscular Dystrophy. 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