{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:21:11Z","timestamp":1760149271484,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Metastatic urothelial carcinoma of the renal pelvis (MUCP), a type of metastatic upper tract urothelial carcinoma (MUTUC), is a rare malignancy, and some patients with MUCP present with distant metastasis at the time of diagnosis. MUCP in the gastrointestinal tract is even rarer. Herein, we report a 78-year-old man with MUCP that presented as a duodenal ulcer. He complained of anorexia, dizziness, and melena for one month. Endoscopic examination at a local clinic revealed a duodenal hemorrhagic and ulcerative lesion, and the patient was referred. He noted dark-colored stools with increasing frequency, but he denied hematochezia, coffee ground emesis, weight changes, or abdominal pain. Gastroduodenoscopic examination at our hospital demonstrated an ulcerofungating lesion of the second portion of the duodenum. Colonoscopic findings showed no abnormality. Computed tomography showed a 6.7 cm sized mass abutting the inferior vena cava, second portion of the duodenum, lower pole of the right kidney, and right iliopsoas. The mass showed heterogeneous enhancement and internal hemorrhagic necrosis and infiltrated the perinephric soft tissues, the second portion of the duodenum, the right psoas muscle, the right renal vein, and the right adrenal gland. Duodenal biopsy showed moderately differentiated squamous cell carcinoma. Immunohistochemistry (IHC) showed diffuse and strong positivity for CK5\/6. Tissue from the liver biopsy showed similar histopathologic features and showed GATA3 positivity on IHC. The imprint cytology smears of the liver tissue showed \u201ccercariform\u201d cell features. We confirmed the diagnosis as MUCP. This case illustrated a rare cause of a secondary duodenal tumor, MUCP.<\/jats:p>","DOI":"10.3390\/diagnostics13142455","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:27:32Z","timestamp":1690248452000},"page":"2455","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Duodenal Ulcer: Metastatic Urothelial Carcinoma of the Renal Pelvis"],"prefix":"10.3390","volume":"13","author":[{"given":"Yoo Dong","family":"Won","sequence":"first","affiliation":[{"name":"Department of Radiology, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Lim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-9696","authenticated-orcid":false,"given":"Kyung Jin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Hospital Pathology, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tufano, A., Cordua, N., Nardone, V., Ranavolo, R., Flammia, R.S., D\u2019Antonio, F., Borea, F., Anceschi, U., Leonardo, C., and Morrione, A. (2022). Prognostic Significance of Organ-Specific Metastases in Patients with Metastatic Upper Tract Urothelial Carcinoma. J. Clin. Med., 11.","DOI":"10.3390\/jcm11185310"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1200\/JCO.2011.38.6979","article-title":"Randomized phase III study comparing paclitaxel\/cisplatin\/gemcitabine and gemcitabine\/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC Intergroup Study 30987","volume":"30","author":"Bellmunt","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.eururo.2012.02.018","article-title":"Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery","volume":"62","author":"Rink","year":"2012","journal-title":"Eur. Urol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/dc.21612","article-title":"Fine-needle aspiration diagnosis of metastatic urothelial carcinoma: A review","volume":"40","author":"Cantley","year":"2012","journal-title":"Diagn. Cytopathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/dc.20199","article-title":"Fine-needle aspiration cytology of metastatic transitional cell carcinoma","volume":"32","author":"Dey","year":"2005","journal-title":"Diagn. Cytopathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/dc.10380","article-title":"Statistical analysis of cytologic features useful in separation of metastatic urothelial carcinoma from other metastatic epithelial malignancies","volume":"29","author":"Layfield","year":"2003","journal-title":"Diagn. Cytopathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.juro.2007.03.033","article-title":"Squamous Cell Carcinoma of the Renal Pelvis and Ureter: Incidence, Symptoms, Treatment and Outcome","volume":"178","author":"Lele","year":"2007","journal-title":"J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/(SICI)1097-0339(199806)18:6<409::AID-DC5>3.0.CO;2-3","article-title":"Needle aspiration cytology of metastatic high-grade transitional-cell carcinomas of the urinary tract","volume":"18","author":"Ho","year":"1998","journal-title":"Diagn. Cytopathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/dc.2840130105","article-title":"\u201cCercariform\u201d cells: A clue to the cytodiagnosis of transitional cell origin of metastatic neoplasms?","volume":"13","author":"Powers","year":"1995","journal-title":"Diagn. Cytopathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/modpathol.3880175","article-title":"Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: A survey of 435 cases","volume":"13","author":"Chu","year":"2000","journal-title":"Mod. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/dc.23131","article-title":"GATA3 expression in metastatic urothelial carcinoma in fine needle aspiration cell blocks: A review of 25 cases","volume":"42","author":"Siddiqui","year":"2014","journal-title":"Diagn. Cytopathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0090-4295(85)90526-6","article-title":"Squamous cell carcinoma of renal pelvis","volume":"25","author":"Blacher","year":"1985","journal-title":"Urology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-5347(17)43116-8","article-title":"Squamous cell carcinoma of the renal pelvis","volume":"138","author":"Li","year":"1987","journal-title":"J. Urol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/14\/2455\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:18:02Z","timestamp":1760127482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/14\/2455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":13,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["diagnostics13142455"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13142455","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2023,7,24]]}}}