{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:40:18Z","timestamp":1784292018059,"version":"3.55.0"},"reference-count":25,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We sought to compare native T1 mapping to conventional late gadolinium enhancement (LGE) and T2-STIR techniques in a cohort of consecutive patients undergoing cardiac MRI (CMR). CMR was performed in 323 patients, 206 males (64%), mean age 54 \u00b1 8 years, and in 27 age- and sex- matched healthy controls. In T2-STIR images, myocardial hyperintensity suggesting edema was found in 41 patients (27%). LGE images were positive in 206 patients (64%). T1 mapping was abnormal in 171 (49%). In 206 patients (64%), a matching between LGE and native T1 was found. T1 was abnormal in 32 out of 41 (78%) with edema in T2-STIR images. Overall, LGE and\/or T2-STIR were abnormal in 209 patients, whereas native T1 was abnormal in 154 (52%). Conventional techniques and T1 mapping were concordant in 208 patients (64%). In 39 patients, T1 mapping was positive despite negative conventional techniques (12%). T1 mapping was able in conditions with diffuse myocardial damage such as cardiac amyloidosis, scleroderma, and Fabry disease (additive role in 42%). In contrast, T1 mapping was less effective in cardiac disease with regional distribution of myocardial damage such as myocardial infarction, HCM, and myocarditis. In conclusion, conventional LGE\/T2-STIR and T1 mapping are complementary techniques and should be used together in every CMR examination.<\/jats:p>","DOI":"10.3390\/diagnostics13142461","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:27:32Z","timestamp":1690248452000},"page":"2461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic Role of Native T1 Mapping Compared to Conventional Magnetic Resonance Techniques in Cardiac Disease in a Real-Life Cohort"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-915X","authenticated-orcid":false,"given":"Giovanni Donato","family":"Aquaro","sequence":"first","affiliation":[{"name":"Academic Radiology Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Monastero","sequence":"additional","affiliation":[{"name":"Gabriele Monasterio CNR-Tuscany Foundation, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Todiere","sequence":"additional","affiliation":[{"name":"Academic Radiology Unit, Department of Translational Research and of New Technology in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-340X","authenticated-orcid":false,"given":"Andrea","family":"Barison","sequence":"additional","affiliation":[{"name":"Academic Radiology Unit, Department of Translational Research and of New Technology in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-3698","authenticated-orcid":false,"given":"Carmelo","family":"De Gori","sequence":"additional","affiliation":[{"name":"Academic Radiology Unit, Department of Translational Research and of New Technology in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crysanthos","family":"Grigoratos","sequence":"additional","affiliation":[{"name":"Academic Radiology Unit, Department of Translational Research and of New Technology in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Parisella","sequence":"additional","affiliation":[{"name":"Gabriele Monasterio CNR-Tuscany Foundation, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5262-4489","authenticated-orcid":false,"given":"Lorenzo","family":"Faggioni","sequence":"additional","affiliation":[{"name":"Gabriele Monasterio CNR-Tuscany Foundation, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-886X","authenticated-orcid":false,"given":"Dania","family":"Cioni","sequence":"additional","affiliation":[{"name":"Academic Radiology Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Lencioni","sequence":"additional","affiliation":[{"name":"Academic Radiology Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-4559","authenticated-orcid":false,"given":"Emanuele","family":"Neri","sequence":"additional","affiliation":[{"name":"Gabriele Monasterio CNR-Tuscany Foundation, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12968-016-0308-4","article-title":"Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: A comprehensive review","volume":"18","author":"Haaf","year":"2017","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"C130","DOI":"10.1093\/eurheartjsupp\/suad015","article-title":"Diagnostic and prognostic role of late gadolinium enhancement in cardiomyopathies","volume":"25","author":"Aquaro","year":"2023","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jcmg.2015.11.005","article-title":"T1 Mapping: Basic Techniques and Clinical Applications","volume":"9","author":"Taylor","year":"2016","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1148\/rg.342125121","article-title":"Myocardial T1 mapping: Techniques and potential applications","volume":"34","author":"Burt","year":"2014","journal-title":"Radiographics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1532-429X-16-2","article-title":"T1-mapping in the heart: Accuracy and precision","volume":"16","author":"Kellman","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10741-017-9627-2","article-title":"T1 mapping in cardiac MRI","volume":"22","author":"Radenkovic","year":"2017","journal-title":"Heart Fail. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2459\/JCM.0000000000000275","article-title":"Prognostic significance of myocardial extracellular volume fraction in nonischaemic dilated cardiomyopathy","volume":"16","author":"Barison","year":"2015","journal-title":"J. Cardiovasc. Med. (Hagerstown)"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12968-017-0389-8","article-title":"Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)","volume":"19","author":"Messroghli","year":"2017","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jcmg.2013.03.008","article-title":"T(1) mapping for the diagnosis of acute myocarditis using CMR: Comparison to T2-weighted and late gadolinium enhanced imaging","volume":"6","author":"Ferreira","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_10","first-page":"404","article-title":"Role of cardiac T1 mapping and extracellular volume in the assessment of myocardial infarction","volume":"19","author":"Garg","year":"2018","journal-title":"Anatol. J. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1148\/radiol.2019190651","article-title":"MRI T1 Mapping in Hypertrophic Cardiomyopathy: Evaluation in Patients Without Late Gadolinium Enhancement and Hemodynamic Obstruction","volume":"294","author":"Xu","year":"2020","journal-title":"Radiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/ehjci\/jex323","article-title":"Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: The importance of clinical context","volume":"19","author":"Quarta","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Todiere, G., Pisciella, L., Barison, A., Del Franco, A., Zachara, E., Piaggi, P., Re, F., Pingitore, A., Emdin, M., and Lombardi, M. (2014). Abnormal T2-STIR magnetic resonance in hypertrophic cardiomyopathy: A marker of advanced disease and electrical myocardial instability. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111366"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.amjcard.2009.09.045","article-title":"Usefulness of delayed enhancement by magnetic resonance imaging in hypertrophic cardiomyopathy as a marker of disease and its severity","volume":"105","author":"Aquaro","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jcmg.2012.03.011","article-title":"Geometric assessment of asymmetric septal hypertrophic cardiomyopathy by CMR","volume":"5","author":"Florian","year":"2012","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jcmg.2012.11.013","article-title":"Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis","volume":"6","author":"Karamitsos","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10554-014-0436-6","article-title":"Myocardial signal intensity decay after gadolinium injection: A fast and effective method for the diagnosis of cardiac amyloidosis","volume":"30","author":"Aquaro","year":"2014","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1055\/a-0836-2723","article-title":"Assessment of Cardiac Involvement in Fabry Disease (FD) with Native T1 Mapping","volume":"191","author":"Roller","year":"2019","journal-title":"Rofo"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Aquaro, G.D., De Gori, C., Faggioni, L., Parisella, M.L., Aringhieri, G., Cioni, D., Lencioni, R., and Neri, E. (2022). Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features. Diagnostics, 12.","DOI":"10.20944\/preprints202210.0200.v1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12968-014-0099-4","article-title":"Reproducibility of native myocardial T1 mapping in the assessment of Fabry disease and its role in early detection of cardiac involvement by cardiovascular magnetic resonance","volume":"16","author":"Pica","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/ehjci\/jeu183","article-title":"T1 mapping in dilated cardiomyopathy with cardiac magnetic resonance: Quantification of diffuse myocardial fibrosis and comparison with endomyocardial biopsy","volume":"16","author":"Buss","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_22","first-page":"100422","article-title":"Native T1 time and extracellular volume fraction in differentiation of normal myocardium from non-ischemic dilated and hypertrophic cardiomyopathy myocardium: A systematic review and meta-analysis","volume":"25","author":"Minegishi","year":"2019","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5114\/reum.2018.75520","article-title":"Value of cardiac magnetic resonance imaging in systemic sclerosis","volume":"56","author":"Chaosuwannakit","year":"2018","journal-title":"Reumatologia."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1016\/j.jacc.2018.09.072","article-title":"Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations","volume":"72","author":"Ferreira","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/jmri.27639","article-title":"Myocardial T1 Values at 1.5\u2009T: Normal Values for General Electric Scanners and Sex-Related Differences","volume":"54","author":"Meloni","year":"2021","journal-title":"J. Magn. Reson. 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