{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:04:41Z","timestamp":1792555481059,"version":"4.5.0"},"reference-count":9,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Acute hemorrhagic encephalomyelitis (AHEM) is the most severe form of acute disseminated encephalomyelitis (ADEM). Patients with AHEM usually have unfavorable outcomes with high mortality rate. We reported a middle-aged male, who was diagnosed with AHEM and died 35 days after admission even under intensive immune therapy. Clinical courses were recorded and serial MR images were demonstrated to illustrate the rapidly changes in brain parenchyma. By highlighting these aspects, we hope to provide valuable insights for future studies and potential advancements in the management of AHEM.<\/jats:p>","DOI":"10.3390\/diagnostics13152481","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T01:50:37Z","timestamp":1690422637000},"page":"2481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rapid Progressive Fatal Acute Hemorrhagic Encephalomyelitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-256X","authenticated-orcid":false,"given":"Ssu-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-5045","authenticated-orcid":false,"given":"Hung-Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology, Taichung Veterans General Hospital, Taichung 407219, Taiwan"},{"name":"School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan"},{"name":"Department of Neurology, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan"},{"name":"Dementia and Parkinson\u2019s Disease Integrated Center, Taichung Veterans General Hospital, Taichung 407219, Taiwan"},{"name":"Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung 407219, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"577751","DOI":"10.1016\/j.jneuroim.2021.577751","article-title":"Acute haemorrhagic leukoencephalitis (AHLE)\u2014Our experience and a short review","volume":"361","author":"Pujari","year":"2021","journal-title":"J. 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