{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:34:54Z","timestamp":1785771294893,"version":"3.56.0"},"reference-count":35,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>This study aimed to quantify serum C-reactive protein (CRP) values in periodontally healthy people and explore the relationship between serum CRP levels and chronic periodontitis, and the influence of scaling as well as root planing (SRP) on serum CRP levels. The study included 100 systemically healthy adults (n = 100; 50 males and 50 females) who were separated into two groups: Group A (control) n = 50; periodontally healthy subjects and Group B (test) n = 50; subjects with chronic periodontitis. The test group (group B) was further separated randomly into two groups: B1 (n = 25) and B2 (n = 25). The clinical parameters and serum CRP levels were measured only once in Group A and before SRP in Group B1 subjects. In Group B2 subjects the clinical parameters and serum CRP levels were measured only after two months following SRP. For group A, B1, and B2 (the readings recorded after SRP) the mean gingival index scores were 0.146, 2.437, and 1.052, respectively, while the plaque index was 0.414, 2.499, and 0.954, respectively. Probing pocket depth (PPD) and clinical attachment loss (CAL) showed statistically significant differences between three groups, with higher values in patients with periodontitis before intervention (2.196 \u00b1 0.49; 1.490 \u00b1 0.23), respectively. Healthy controls (Group A) had a C-reactive protein level of 0.04820 mg\/dL, while group B1 (test) had 1.678 mg\/dL and 0.8892 mg\/dL (group B2). C-reactive protein levels were observed to be greater in the test group (groups B1 and B2), and these differences were statistically significant (p &lt; 0.001). Chronic periodontitis enhances blood levels of systemic inflammatory markers like CRP, which has been reduced by periodontal treatment with SRP.<\/jats:p>","DOI":"10.3390\/diagnostics13152483","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T01:50:37Z","timestamp":1690422637000},"page":"2483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Variations of Serum CRP Levels in Periodontal Health and Diseases: A Clinico-Biochemical Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Sidharth","family":"Shankar","sequence":"first","affiliation":[{"name":"ECHS, Air Force Hospital, Gorakhpur 273014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Manjunath","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Institute of Dental Sciences, Bareilly 243006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad Mohammad","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3178-9513","authenticated-orcid":false,"given":"Kiran Kumar","family":"Ganji","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"},{"name":"Department of Periodontics & Implantology, Datta Meghe Institute of Higher Education & Research, Sharad Pawar Dental College, Sawangi (Meghe), Wardha 442107, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendra Reddy","family":"Nagate","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar T.","family":"Ghokale","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-1253","authenticated-orcid":false,"given":"Anil Kumar","family":"Nagarajappa","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukhatar Ahmed","family":"Javali","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-6478","authenticated-orcid":false,"given":"Shreyas","family":"Tikare","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-8198","authenticated-orcid":false,"given":"Mohasin Abdul","family":"Khader","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tim.2017.09.008","article-title":"Oral biofilms: Pathogens, matrix, and polymicrobial interactions in microenvironments","volume":"26","author":"Bowen","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. 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