{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:03:39Z","timestamp":1774645419724,"version":"3.50.1"},"reference-count":54,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Humanidades, Ciencias, y Tecnologias (CONAHCyT), Mexico","award":["CVU 426168"],"award-info":[{"award-number":["CVU 426168"]}]},{"name":"FUNDACION IMSS","award":["CVU 426168"],"award-info":[{"award-number":["CVU 426168"]}]},{"name":"Universidad Nacional Autonoma de Mexico","award":["CVU 426168"],"award-info":[{"award-number":["CVU 426168"]}]},{"name":"Research Directorate, Hospital General de Mexico","award":["CVU 426168"],"award-info":[{"award-number":["CVU 426168"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Radiomics refers to the acquisition of traces of quantitative features that are usually non-perceptible to human vision and are obtained from different imaging techniques and subsequently transformed into high-dimensional data. Diffuse midline gliomas (DMG) represent approximately 20% of pediatric CNS tumors, with a median survival of less than one year after diagnosis. We aimed to identify which radiomics can discriminate DMG tumor regions (viable tumor and peritumoral edema) from equivalent midline normal tissue (EMNT) in patients with the positive H3.F3K27M mutation, which is associated with a worse prognosis. Patients and methods: This was a retrospective study. From a database of 126 DMG patients (children, adolescents, and young adults), only 12 had H3.3K27M mutation and available brain magnetic resonance DICOM file. The MRI T1 post-gadolinium and T2 sequences were uploaded to LIFEx software to post-process and extract radiomic features. Statistical analysis included normal distribution tests and the Mann\u2013Whitney U test performed using IBM SPSS\u00ae (Version 27.0.0.1, International Business Machines Corp., Armonk, NY, USA), considering a significant statistical p-value \u2264 0.05. Results: EMNT vs. Tumor: From the T1 sequence 10 radiomics were identified, and 14 radiomics from the T2 sequence, but only one radiomic identified viable tumors in both sequences (p &lt; 0.05) (DISCRETIZED_Q1). Peritumoral edema vs. EMNT: From the T1 sequence, five radiomics were identified, and four radiomics from the T2 sequence. However, four radiomics could discriminate peritumoral edema in both sequences (p &lt; 0.05) (CONVENTIONAL_Kurtosis, CONVENTIONAL_ExcessKurtosis, DISCRETIZED_Kurtosis, and DISCRETIZED_ExcessKurtosis). There were no radiomics useful for distinguishing tumor tissue from peritumoral edema in both sequences. Conclusions: Less than 5% of the radiomic characteristics identified tumor regions of medical\u2013clinical interest in T1 and T2 sequences of conventional magnetic resonance imaging. The first-order and second-order radiomic features suggest support to investigators and clinicians for careful evaluation for diagnosis, patient classification, and multimodality cancer treatment planning.<\/jats:p>","DOI":"10.3390\/diagnostics13162669","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:28:13Z","timestamp":1692008893000},"page":"2669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of Radiomic Signatures in Brain MRI Sequences T1 and T2 That Differentiate Tumor Regions of Midline Gliomas with H3.3K27M Mutation"],"prefix":"10.3390","volume":"13","author":[{"given":"Maria-Fatima","family":"Chilaca-Rosas","sequence":"first","affiliation":[{"name":"Radiotherapy Department, Hospital de Oncolog\u00eda, Centro Medico Nacional Siglo XXI, Instituto Mexicano Del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-6426","authenticated-orcid":false,"given":"Manuel-Tadeo","family":"Contreras-Aguilar","sequence":"additional","affiliation":[{"name":"Radiotherapy Department, Hospital de Oncolog\u00eda, Centro Medico Nacional Siglo XXI, Instituto Mexicano Del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-6244","authenticated-orcid":false,"given":"Melissa","family":"Garcia-Lezama","sequence":"additional","affiliation":[{"name":"Directorate of Research, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-7508","authenticated-orcid":false,"given":"David-Rafael","family":"Salazar-Calderon","sequence":"additional","affiliation":[{"name":"Radiotherapy Department, Hospital de Oncolog\u00eda, Centro Medico Nacional Siglo XXI, Instituto Mexicano Del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-6032","authenticated-orcid":false,"given":"Raul-Gabriel","family":"Vargas-Del-Angel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-0917","authenticated-orcid":false,"given":"Sergio","family":"Moreno-Jimenez","sequence":"additional","affiliation":[{"name":"Neurological Center, Neurosurgery Department of National Institute of Neurology and Neurosurgery, Mexico City 14269, Mexico"},{"name":"Neurological Center, Neurosurgery Department of American British Cowdray Medical Center, Mexico City 01120, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-1931","authenticated-orcid":false,"given":"Patricia","family":"Pi\u00f1a-Sanchez","sequence":"additional","affiliation":[{"name":"Oncology Diagnostic, Unidad de Investigacion Medica en Enfermedades Oncologicas U.I.M.E.O, Hospital de Oncolog\u00eda, Centro Medico Nacional Siglo XXI, Instituto Mexicano Del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul-Rogelio","family":"Trejo-Rosales","sequence":"additional","affiliation":[{"name":"Medical Oncology, Hospital de Oncolog\u00eda, Centro Medico Nacional Siglo XXI, Instituto Mexicano Del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-5177","authenticated-orcid":false,"given":"Felipe-Alfredo","family":"Delgado-Martinez","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Service, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-5289","authenticated-orcid":false,"given":"Ernesto","family":"Roldan-Valadez","sequence":"additional","affiliation":[{"name":"Directorate of Research, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City 06720, Mexico"},{"name":"Department of Radiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119992 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ccell.2017.08.017","article-title":"Integrated Molecular Meta-Analysis of 1000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma","volume":"32","author":"Mackay","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"960509","DOI":"10.3389\/fonc.2022.960509","article-title":"Molecular testing for adolescent and young adult central nervous system tumors: A Canadian guideline","volume":"12","author":"Macdonald","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nikam, R.M., Yue, X., Kaur, G., Kandula, V., Khair, A., Kecskemethy, H.H., Averill, L.W., and Langhans, S.A. (2022). 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