{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T23:40:11Z","timestamp":1778197211627,"version":"3.51.4"},"reference-count":107,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as \u201csternal\u201d, \u201cmanubrium\u201d, and \u201cmetastasis\u201d within the title and\/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports). A prior unpublished case in point is also introduced (percutaneous incisional biopsy was used to address a 10 cm sternal tumour upon first admission on an apparently healthy male). The studies (n = 14) may be classified into one of three groups: studies addressing the incidence of bone metastases (including sternum) amid different primary cancers, such as prostate cancer (N = 122 with bone metastases, 83% of them with chest wall metastases), head and neck cancers (N = 3620, 0.8% with bone metastases, and 10.34% of this subgroup with sternum involvement); and glioblastoma (N = 92 with bone metastases, 37% of them with non-vertebral metastases, including the sternum); assessment cohorts, including breast cancer (N = 410; accuracy and sensitivity of PET\/CT vs. bone scintigraphy is superior with concern to sternum spreading) and bone metastases of unknown origin (N = 83, including a subgroup with sternum metastases; some features of PET\/CT help the differentiation with multiple myeloma); and cohorts with various therapeutic approaches, such as palliative arterial embolization (N = 10), thymic neuroendocrine neoplasia (1\/5 detected with sternum metastases), survival rates for sternum metastases vs. non-sternum chest wall involvement (N = 87), oligo-metastatic (sternal) breast cancer (3 studies, N = 16 for all of them), oligo-metastatic head and neck cancer (N = 81), conformal radiotherapy (N = 24,215, including an analysis on sternum spreading), and EBRT followed by MR-HIFU (N = 6). Core data coming from the isolated case reports (N = 34) showed a female to male ratio of 1.6; the females\u2019 ages were between 34 and 80 (mean of 57.28) and the males\u2019 ages varied between 33 and 79 (average of 58.78) years. The originating tumour profile revealed that the most frequent types were mammary (N = 8, all females) and thyroid (N = 9, both women and men), followed by bladder (N = 3), lung (N = 2), and kidney (N = 2). There was also one case for each of the following: adenoid cystic carcinoma of the jaw, malignant melanoma, caecum MiNEN, a brain and an extracranial meningioma, tongue carcinoma, cholangiocarcinoma, osteosarcoma, and hepatocellular carcinoma. To our knowledge, this is the most complex and the largest analysis of prior published data within the time frame of our methods. These data open up new perspectives of this intricate, dynamic, and challenging domain of sternum metastases. Awareness is a mandatory factor since the patients may have a complex multidisciplinary medical and\/or surgical background or they are admitted for the first time with this condition; thus, the convolute puzzle will start from this newly detected sternal lump. Abbreviations: N = number of patients; n = number of studies; PET\/CT = positron emission tomography\/computed tomography; EVRT = external beam radiotherapy; MR-HIFU = magnetic resonance-guided high-intensity focused ultrasound; MiNEN = mixed neuroendocrine-non-neuroendocrine tumour.<\/jats:p>","DOI":"10.3390\/diagnostics13162698","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:42:29Z","timestamp":1692268949000},"page":"2698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-3835","authenticated-orcid":false,"given":"Mara","family":"Carsote","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Endocrinology, C.I. Parhon National Institute of Endocrinology, 011863 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Terzea","sequence":"additional","affiliation":[{"name":"Department of Pathology, C.I. Parhon National Institute of Endocrinology, 011863 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florina","family":"Vasilescu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Carol Davila Central Military Emergency University Hospital, 010731 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0326-1145","authenticated-orcid":false,"given":"Anca-Pati","family":"Cucu","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Dr. Carol Davila Central Military Emergency University Hospital, 010731 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Ciuche","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Dr. Carol Davila Central Military Emergency University Hospital, 010731 Bucharest, Romania"},{"name":"Department 4\u2014Cardio-Thoracic Pathology, Thoracic Surgery II Discipline, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu","family":"Nistor","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Dr. Carol Davila Central Military Emergency University Hospital, 010731 Bucharest, Romania"},{"name":"Department 4\u2014Cardio-Thoracic Pathology, Thoracic Surgery II Discipline, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1104536","DOI":"10.3389\/fonc.2023.1104536","article-title":"Full-thickness chest wall resection for malignant chest wall tumors and postoperative problems","volume":"13","author":"Asanuma","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"975603","DOI":"10.3389\/fonc.2022.975603","article-title":"The sternum reconstruction: Present and future perspectives","volume":"12","author":"Aramini","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_3","first-page":"2349","article-title":"Massive chest wall resection and reconstruction for malignant disease","volume":"9","author":"Foroulis","year":"2016","journal-title":"OncoTargets Ther."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gonfiotti, A., Salvicchi, A., and Voltolini, L. (2022). Chest-Wall Tumors and Surgical Techniques: State-of-the-Art and Our Institutional Experience. J. Clin. Med., 11.","DOI":"10.3390\/jcm11195516"},{"key":"ref_5","first-page":"25","article-title":"Surgical treatment of patients with chest wall metastases","volume":"8","author":"Bukharov","year":"2022","journal-title":"Khirurgiia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.21037\/tlcr-21-935","article-title":"Expert consensus on resection of chest wall tumors and chest wall reconstruction","volume":"10","author":"Wang","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s13304-023-01562-z","article-title":"New perspectives in prosthetic reconstruction in chest wall resection","volume":"75","author":"Duranti","year":"2023","journal-title":"Updates Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/jso.27151","article-title":"The oncologic efficacy of extended thoracic resections","volume":"127","author":"Kader","year":"2023","journal-title":"J. Surg. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.21037\/shc-21-8","article-title":"Complex anterior chest wall reconstruction after extensive oncologic resections: A narrative review","volume":"5","author":"Gritsiuta","year":"2021","journal-title":"Shanghai Chest"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/PRS.0000000000004597","article-title":"Oncologic Resection and Reconstruction of the Chest Wall: A 19-Year Experience in a Single Center","volume":"142","author":"Salo","year":"2018","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_11","first-page":"226","article-title":"Sternal resection of a solitary renal cell carcinoma metastasis: A case report and a literature review","volume":"25","author":"Ulys","year":"2019","journal-title":"Acta Med. Litu."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijscr.2019.09.022","article-title":"Can surgery relieve pain and act as first-line treatment for a large metastasis of the sternum?","volume":"63","author":"Manfredini","year":"2018","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_13","first-page":"1846","article-title":"A Case of Late Recurrence of Breast Cancer with Chest Wall Recurrence 43 Years after Surgery","volume":"48","author":"Oshima","year":"2021","journal-title":"Gan Kagaku Ryoho Cancer Chemother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2217\/imt-2022-0104","article-title":"Excellent response of refractory triple-negative breast cancer to sintilimab plus chemotherapy: A case report","volume":"15","author":"Yao","year":"2023","journal-title":"Immunotherapy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.21614\/chirurgia.116.5.627","article-title":"Management of Epicardial Metastasis in Breast Cancer","volume":"116","author":"Rebegea","year":"2021","journal-title":"Chirurgia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12328-020-01285-3","article-title":"Colorectal and gastric metastases from lobular breast cancer that resembled superficial neoplastic lesions","volume":"14","author":"Kobayashi","year":"2021","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e21344","DOI":"10.1097\/MD.0000000000021344","article-title":"Concomitant fulvestrant with reirradiation for unresectable locoregional recurrent estrogen receptor positive (ER+) breast cancer: A case report and narrative review","volume":"99","author":"Ding","year":"2020","journal-title":"Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"rjaa272","DOI":"10.1093\/jscr\/rjaa272","article-title":"Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread","volume":"2020","author":"Mohamed","year":"2020","journal-title":"J. Surg. Case Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/RLU.0000000000004644","article-title":"Internal Thoracic Vein Tumor Thrombus From Sternal Melanoma Metastasis on 18F-FDG PET\/CT","volume":"48","author":"Ensle","year":"2023","journal-title":"Clin. Nucl. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.4103\/jcrt.JCRT_146_20","article-title":"Incidence of bone metastasis in head and neck malignancy: A retrospective study","volume":"18","author":"Bhandari","year":"2022","journal-title":"J. Cancer Res. Ther."},{"key":"ref_21","first-page":"E1476","article-title":"Treatment of Oligometastatic Disease in Squamous Cell Carcinoma of the Head and Neck","volume":"131","author":"Vincent","year":"2020","journal-title":"Laryngoscope"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e14615","DOI":"10.7717\/peerj.14615","article-title":"Development and validation of a novel risk model in newly diagnosed de novo bone metastatic prostate cancer (M1b): A retrospective study","volume":"11","author":"Zhang","year":"2023","journal-title":"PeerJ"},{"key":"ref_23","first-page":"2422086","article-title":"A Case of Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible","volume":"2023","author":"Sasaki","year":"2023","journal-title":"Case Rep. Dent."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11060-022-04025-4","article-title":"Bone metastasis from glioblastoma: A systematic review","volume":"158","author":"Strong","year":"2022","journal-title":"J. Neuro-Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/IJCIIS.IJCIIS_5_20","article-title":"Diffuse bone metastasis from cholangiocarcinoma involving the sternum: A case report and review of literature","volume":"11","author":"Ramahi","year":"2021","journal-title":"Int. J. Crit. Illn. Inj. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13019-020-01247-3","article-title":"Radical resection and reconstruction of the sternum for metastasis of hepatocellular carcinoma","volume":"15","author":"Yoon","year":"2020","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1186\/1752-1947-8-405","article-title":"Selective embolization for hypervascular metastasis from differentiated thyroid cancer: A case series","volume":"8","author":"Son","year":"2014","journal-title":"J. Med. Case Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105663","DOI":"10.1016\/j.ijscr.2021.105663","article-title":"Sternal metastasis as first manifestation of a papillary thyroid carcinoma: A case report","volume":"80","author":"Hafidi","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/hed.24655","article-title":"Systematic review of site distribution of bone metastases in differentiated thyroid cancer","volume":"39","author":"Osorio","year":"2017","journal-title":"Head Neck"},{"key":"ref_30","first-page":"8679149","article-title":"Lenvatininb as Treatment for Na\u00efve Patients with Aggressive Thyroid Cancer Bone Metastases and Bad Performance Status","volume":"2020","author":"Pinillos","year":"2020","journal-title":"Case Rep. Oncol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3348\/jksr.2020.81.4.939","article-title":"Metastasis of Poorly Differentiated Thyroid Carcinoma to the Sternum: A Case Report","volume":"81","author":"Kim","year":"2020","journal-title":"J. Korean Soc. Radiol."},{"key":"ref_32","first-page":"e31294","article-title":"Synchronous Sternal Metastasectomy and Total Thyroidectomy for Differentiated Thyroid Cancer: A Rare Case Report","volume":"14","author":"Paspala","year":"2022","journal-title":"Cureus"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.amsu.2020.11.076","article-title":"Complete diaphysis resorption of the femur: A case report in a metastatic papillary thyroid cancer","volume":"60","author":"Suwardjo","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e8786","DOI":"10.1097\/MD.0000000000008786","article-title":"Partial resection and reconstruction of the sternum for treatment of metachronous sternal metastasis of thyroid carcinoma: A case report","volume":"96","author":"Lan","year":"2017","journal-title":"Medicine"},{"key":"ref_35","first-page":"80","article-title":"Follicular thyroid cancer with sternal metastasis-challenges and outcomes","volume":"72","author":"Syazni","year":"2017","journal-title":"Med. J. Malays."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1507\/endocrj.EJ22-0033","article-title":"Surgical indications for upper mediastinal dissection by sternotomy in patients with papillary thyroid carcinoma","volume":"69","author":"Moritani","year":"2022","journal-title":"Endocr. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e235967","DOI":"10.1136\/bcr-2020-235967","article-title":"Sternal metastatectomy in a case of papillary thyroid carcinoma","volume":"13","author":"Pradeep","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13044-020-00083-w","article-title":"Macrofollicular variant of papillary thyroid carcinoma with metastasis to femur","volume":"13","year":"2020","journal-title":"Thyroid. Res."},{"key":"ref_39","first-page":"e30298","article-title":"Oncocytic Cell Carcinoma of the Thyroid: A Case Report and an Overview of the Diagnosis, Treatment Modalities, and Prognosis","volume":"14","author":"Syed","year":"2022","journal-title":"Cureus"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12105-022-01520-y","article-title":"Top Ten Oncocytic Head and Neck Lesions to Contemplate","volume":"17","author":"Bullock","year":"2023","journal-title":"Head Neck Pathol."},{"key":"ref_41","first-page":"70","article-title":"Hurthle Cell Thyroid Carcinoma with Liver and Paraaortic Abdominal Nodal Metastasis: Progression on Sorafenib Therapy after Initial Disease Stabilization","volume":"22","author":"Loharkar","year":"2022","journal-title":"World J. Nucl. Med."},{"key":"ref_42","first-page":"88","article-title":"Cutaneous thyroid carcinoma sixteen years after benign total thyroidectomy: A unique case","volume":"24","author":"Klonaris","year":"2020","journal-title":"Hippokratia"},{"key":"ref_43","first-page":"269","article-title":"Peptide receptor radionuclide therapy (PRRT) in radioiodine-refractory thyroid cancer: A case report of significant response to lu177 DOTA-TATE treatment","volume":"66","author":"Aryana","year":"2022","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"896287","DOI":"10.3389\/fendo.2022.896287","article-title":"Peptide Receptor Radionuclide Therapy in Thyroid Cancer","volume":"13","author":"Gubbi","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ando.2022.08.001","article-title":"Feasibility and therapeutic potential of the 68Ga\/177Lu-DOTATATE theranostic pair in patients with metastatic medullary thyroid carcinoma","volume":"84","author":"Dadgar","year":"2023","journal-title":"Ann. Endocrinol."},{"key":"ref_46","first-page":"6662071","article-title":"Clavicular Metastasis as an Initial Presentation of Papillary Thyroid Cancer","volume":"2021","author":"Fung","year":"2021","journal-title":"Case Rep. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3892\/ol.2020.11685","article-title":"Anlotinib as a molecular targeted therapy for tumors (Review)","volume":"20","author":"Gao","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.12998\/wjcc.v11.i12.2839","article-title":"Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature","volume":"11","author":"Zhang","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e000659","DOI":"10.20945\/2359-3997000000659","article-title":"Neoadjuvant therapy with anlotinib in a locally advanced and pulmonary metastasis PTC patient harboring TERT promoter and BRAFV600E mutations: A case report","volume":"67","author":"Su","year":"2023","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13045-018-0664-7","article-title":"Anlotinib: A novel multi-targeting tyrosine kinase inhibitor in clinical development","volume":"11","author":"Shen","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e600","DOI":"10.1093\/oncolo\/oyad087","article-title":"Bone Metastases Detection in Patients with Breast Cancer: Does Bone Scintigraphy Add Information to PET\/CT?","volume":"28","author":"Santos","year":"2023","journal-title":"Oncologist"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1097\/RLU.0000000000004246","article-title":"Prostate-Specific Membrane Antigen\u2013Avid Bone Metastases From Urothelial Carcinoma of the Bladder","volume":"47","author":"Zhao","year":"2022","journal-title":"Clin. Nucl. Med."},{"key":"ref_53","first-page":"713","article-title":"Differential performances in lesions and radio-tracer of 18F-FDG PET\/CT between multiple myeloma and unknown osteolytic metastasis","volume":"19","author":"Deng","year":"2023","journal-title":"Curr. Med. Imaging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s12282-021-01234-z","article-title":"Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio","volume":"28","author":"Everaert","year":"2021","journal-title":"Breast Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1097\/RLU.0000000000003320","article-title":"Is 68Ga\u2013Prostate-Specific Membrane Antigen PET\/CT Superior than 18F-FDG PET\/CT for Evaluation of Metastatic Osteosarcoma?","volume":"46","author":"Can","year":"2021","journal-title":"Clin. Nucl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000513907","article-title":"Usefulness of Quantitative Bone Single-Photon Emission Computed Tomography\/Computed Tomography for Evaluating the Treatment Response of Bone Metastasis in a Lung Cancer Patient","volume":"14","author":"Kitajima","year":"2021","journal-title":"Case Rep. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e14154","DOI":"10.1097\/MD.0000000000014154","article-title":"The role of combined techniques of scintigraphy and SPECT\/CT in the diagnosis of primary hyperparathyroidism: A case report","volume":"98","author":"Stanciu","year":"2019","journal-title":"Medicine"},{"key":"ref_58","first-page":"348","article-title":"Parathyroidectomy: Is vitamin D a player for a good outcome?","volume":"9","author":"Carsote","year":"2016","journal-title":"J. Med. Life"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105581","DOI":"10.1016\/j.ijscr.2021.01.075","article-title":"Invasive pleomorphic lobular carcinoma of the breast with multiple metastases: A case report","volume":"80","author":"Chen","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"101730","DOI":"10.1016\/j.eucr.2021.101730","article-title":"Solitary metastasis of clear cell renal cell carcinoma in sternum diagnosed unexpectedly during cardiac surgery\u2014A rare but potentially fatal trap","volume":"38","author":"Dergel","year":"2021","journal-title":"Urol. Case Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jso.27164","article-title":"Three-dimensional technologies in chest wall resection and reconstruction","volume":"127","author":"Young","year":"2023","journal-title":"J. Surg. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.21037\/acr.2020.03.08","article-title":"Use of custom made 3-dimensional printed surgical guide for manubrio-sternal resection of solitary breast cancer metastasis: Case report","volume":"4","author":"Fernandez","year":"2020","journal-title":"AME Case Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/15569845231153632","article-title":"3D Printing Technology for Chest Wall Reconstruction With a Sternum-Ribs-Cartilage Titanium Implant: From Ideation to Creation","volume":"18","author":"Goldsmith","year":"2023","journal-title":"Innovations"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"950177","DOI":"10.3389\/fsurg.2022.950177","article-title":"Long-term outcomes after chest wall resection and repair with titanium bars and sternal plates","volume":"9","author":"Clermidy","year":"2022","journal-title":"Front. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.athoracsur.2020.10.032","article-title":"Modified Subxiphoid Thoracoscopic Thymectomy for Locally Invasive Thymoma","volume":"112","author":"Jiang","year":"2020","journal-title":"Ann. Thorac. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.21037\/tcr-22-1150","article-title":"Surgical treatment of intermediate to high grade thymic neuroendocrine neoplasms: Case series of five patients and literature review","volume":"11","author":"Huang","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/j.ejso.2022.07.017","article-title":"Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review","volume":"48","author":"Lau","year":"2022","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2478\/enr-2022-0026","article-title":"A rare case of poorly differentiated mixed neuroendocrine-nonneuroendocrine tumor of the caecum with long term survival: A case report","volume":"56","author":"Polymeris","year":"2022","journal-title":"Endocr. Regul."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3344\/kjp.2021.34.4.375","article-title":"Percutaneous osteoplasty for painful bony lesions: A technical survey","volume":"34","author":"Kim","year":"2021","journal-title":"Korean J. Pain"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s00270-023-03459-1","article-title":"Palliative Arterial Embolization for Metastases of the Sternum","volume":"46","author":"Papalexis","year":"2023","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13256-022-03335-5","article-title":"Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: A case report","volume":"16","author":"Ishikawa","year":"2022","journal-title":"J. Med. Case Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"66","DOI":"10.14338\/IJPT-21-00014","article-title":"Proton Radiotherapy for Patients With Oligometastatic Breast Cancer Involving the Sternum","volume":"8","author":"Johnson","year":"2021","journal-title":"Int. J. Part. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/1754-9485.13075","article-title":"Single-fraction stereotactic ablative body radiotherapy for sternal metastases in oligometastatic breast cancer: Technique and single institution experience","volume":"64","author":"Li","year":"2020","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1200\/JOP.19.00808","article-title":"Advanced Radiation Therapy Technology Use in the Treatment of Bone Metastases in a Public, Salary-Funded, Non-Incentivized Health Care System","volume":"17","author":"Chan","year":"2021","journal-title":"JCO Oncol. Pract."},{"key":"ref_75","first-page":"57","article-title":"Combining radiotherapy and focused ultrasound for pain palliation of cancer induced bone pain; a stage I\/IIa study according to the IDEAL framework","volume":"27","author":"Bartels","year":"2021","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_76","first-page":"e10117","article-title":"Radio-Immunotherapy: A Case Report of \u2018Abscopal Hyper-Progression\u2019?","volume":"12","author":"Koukourakis","year":"2020","journal-title":"Cureus"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e23406","DOI":"10.1097\/MD.0000000000023406","article-title":"Human epidermal growth factor receptor 2-positive metastatic breast cancer with novel epidermal growth factor receptor -ZNF880 fusion and epidermal growth factor receptor E114K mutations effectively treated with pyrotinib: A case report","volume":"99","author":"Yue","year":"2020","journal-title":"Medicine"},{"key":"ref_78","first-page":"97","article-title":"A p16 Positive M1 Oral Tongue Cancer Completely Responsive to the EXTREME Regimen: A Case Report","volume":"46","author":"Iijima","year":"2021","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13019-023-02213-5","article-title":"Multiple local recurrences of primary sternal chondrosarcoma: Tumor manipulation or self-seeding","volume":"18","author":"Jalil","year":"2023","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/SAP.0000000000003334","article-title":"Chondrosarcoma of the Chest Wall: A Single Institution Review of 50 Cases","volume":"90","author":"Laitinen","year":"2023","journal-title":"Ann. Plast. Surg."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"108107","DOI":"10.1016\/j.ijscr.2023.108107","article-title":"Case report: Management of infiltrative basosquamous carcinoma of the sternum","volume":"106","author":"Lo","year":"2023","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.humpath.2023.03.011","article-title":"Conventional chondrosarcoma of the rib cage and sternum: Clinicopathological and molecular analysis of 27 patients treated at a single institution","volume":"136","author":"Abdulfatah","year":"2023","journal-title":"Hum. Pathol."},{"key":"ref_83","first-page":"97","article-title":"Multifocal Osteosarcoma: Multiple Primaries or Metastases? A Report of Rare Case and Review of Literature","volume":"10","author":"Agrawal","year":"2020","journal-title":"J. Orthop. Case Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.21873\/anticanres.14097","article-title":"Chondrosarcoma of the Chest Wall: A Review of 53 Cases from Two Institutions","volume":"40","author":"Lenze","year":"2020","journal-title":"Anticancer. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4103\/jcrt.JCRT_694_17","article-title":"Coughing up: \u201cAdenosquamous carcinoma lung with unusual initial presentation as an ulceroproliferative growth\u201d-case report and review of literature","volume":"16","author":"Singh","year":"2020","journal-title":"J. Cancer Res. Ther."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.radcr.2022.03.035","article-title":"Unusual sites of tuberculosis mimicking skeletal metastases: A case report","volume":"17","author":"Jauhary","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1055\/s-0041-1739378","article-title":"Extrapulmonary Tuberculosis Mimics Diffuse Metastatic Disease: A Case Report","volume":"31","author":"Engin","year":"2021","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.arbres.2020.02.013","article-title":"Metastases of Alveolar Echinococcosis to the Skin, Pleura, Ribs, and the Xiphoid Process: A Case Report","volume":"57","author":"Karaman","year":"2021","journal-title":"Arch. Bronconeumol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1515\/med-2022-0451","article-title":"A case report of dermatomyositis with the missed diagnosis of non-small cell lung cancer and concurrence of pulmonary tuberculosis","volume":"17","author":"Yin","year":"2022","journal-title":"Open Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/1754-9485.13344","article-title":"The sternum: An important review area when reporting pre-surgical staging breast MRI studies","volume":"66","author":"Price","year":"2022","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_91","first-page":"1259","article-title":"A Case of Advanced Late Recurrence of Hormone Receptor Positive Breast Cancer Successfully Treated with Abemaciclib and Anastrozole","volume":"48","author":"Minamoto","year":"2021","journal-title":"Gan Kagaku Ryoho Cancer Chemother."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"S481","DOI":"10.4103\/jcrt.JCRT_649_20","article-title":"A case of soft-tissue tumor over the sternum: A rare case report","volume":"18","author":"Rathod","year":"2022","journal-title":"J. Cancer Res. Ther."},{"key":"ref_93","first-page":"87","article-title":"Manubrium resection and reconstruction for mediastinal tumor: A case report","volume":"25","author":"Silva","year":"2018","journal-title":"Rev. Port. Cir. Cardio-Torac. Vasc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1007\/BF02482828","article-title":"Development of primary leiomyosarcoma of the sternum postirradiation: Report of a case","volume":"28","author":"Aoki","year":"1998","journal-title":"Surg. Today"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Hayashi, K., Fujioka, T., Hara, M., Kumaki, Y., Oda, G., Yamaga, E., Mori, M., Ohnishi, I., Kubota, K., and Nakagawa, T. (2022). Focal Uptake in the Sternum on 18F-FDG-PET\/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer. Diagnostics, 12.","DOI":"10.3390\/diagnostics12102308"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/MNM.0000000000001726","article-title":"Value of subspecialist second opinion reads of 18F-FDG PET-CT examinations for patients with breast cancer","volume":"44","author":"Fardanesh","year":"2023","journal-title":"Nucl. Med. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5114\/jcb.2022.113548","article-title":"CT-guided trans-sternal 125I seeds implantation for masses in the anterior or middle mediastinum","volume":"14","author":"Wang","year":"2022","journal-title":"J. Contemp. Brachyther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.21873\/anticanres.15204","article-title":"Sternal Metastasis of Brain Meningioma\u2014A Case Report","volume":"41","author":"Matsumura","year":"2021","journal-title":"Anticancer. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s13691-020-00435-1","article-title":"Two cases of osteoblastic bone metastasis from muscle-invasive bladder cancer with discrepancy in response to chemotherapy: Problems and limitations of bone biopsy","volume":"9","author":"Ogasawara","year":"2020","journal-title":"Int. Cancer Conf. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"101137","DOI":"10.1016\/j.eucr.2020.101137","article-title":"Renal cell carcinoma revealed by sternal tumefaction: A rare case report and literature review","volume":"31","author":"Irzi","year":"2020","journal-title":"Urol. Case Rep."},{"key":"ref_101","first-page":"5536675","article-title":"Benign Metastasizing Leiomyoma of the Uterus with Pulmonary and Bone Metastases","volume":"2021","author":"Padhi","year":"2021","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"omaa005","DOI":"10.1093\/omcr\/omaa005","article-title":"Malignant primary pulmonary meningioma with bone metastasis","volume":"2020","author":"Minami","year":"2020","journal-title":"Oxf. Med. Case Rep."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Nistor, C.-E., Pantile, D., Stanciu-Gavan, C., Ciuche, A., and Moldovan, H. (2022). Diagnostic and Therapeutic Characteristics in Patients with Pneumotorax Associated with COVID-19 versus Non-COVID-19 Pneumotorax. Medicina, 58.","DOI":"10.3390\/medicina58091242"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"317","DOI":"10.21614\/chirurgia.2719","article-title":"Cervico-Thoracic Air Collections in COVID-19 Pneumonia Patients-Our Experience and Brief Review","volume":"117","author":"Nistor","year":"2022","journal-title":"Chirurgia"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00595-005-3134-0","article-title":"Resection of Sternal Tumors and Reconstruction of the Thorax: A Review of 15 Patients","volume":"36","author":"Haraguchi","year":"2006","journal-title":"Surg. Today"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13044-019-0073-1","article-title":"Pre-sternal thyroid swellings: A case of rare aberrant site recurrence and review of literature","volume":"12","author":"Bains","year":"2019","journal-title":"Thyroid. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/icvts\/ivz214","article-title":"Chest wall reconstruction with a novel titanium mesh after partial sternectomy for chondrosarcoma","volume":"30","author":"Aprile","year":"2020","journal-title":"Interact. Cardiovasc. Thorac. Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/16\/2698\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:36:10Z","timestamp":1760128570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/16\/2698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":107,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["diagnostics13162698"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13162698","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]}}}