{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T14:44:42Z","timestamp":1772289882694,"version":"3.50.1"},"reference-count":128,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Reversible cerebral vasoconstriction syndrome (RCVS) is a condition with variable outcomes presenting a new onset thunderclap headache accompanied by focal neurological symptoms or seizures. It can be idiopathic or arise secondarily to a variety of trigger factors. The condition is increasingly recognized in clinical practice, but many facets remain poorly understood. This article aims to clarify the headache characteristics in RCVS, the temporal association of angiographic findings, the potential association of the condition with SARS-CoV-2 infection, and the clinical presentation of RCVS in children and is based on a systematic PRISMA search for published analytical or large descriptive observational studies. Data from 60 studies that fulfilled specific criteria were reviewed. Most people with RCVS exhibit a typical thunderclap, explosive, or pulsatile\/throbbing headache, or a similar acute and severe headache that takes longer than 1 min to peak. Atypical presentations or absence of headaches are also reported and may be an underrecognized phenotype. In many cases, headaches may persist after resolution of RCVS. Focal deficits or seizures are attributed to associated complications including transient ischemic attacks, posterior reversible encephalopathy syndrome, ischemic stroke, cerebral edema, and intracranial hemorrhage. The peak of vasoconstriction occurs usually within two weeks after clinical onset, possibly following a pattern of centripetal propagation, and tends to resolve completely within 3 months, well after symptoms have subsided. There are a few reports of RCVS occurring in relation to SARS-CoV-2 infection, but potential underlying pathophysiologic mechanisms and etiological associations have not been confirmed. RCVS occurs in children most often in the context of an underlying disease. Overall, the available data in the literature are scattered, and large-scale prospective studies and international collaborations are needed to further characterize the clinical presentation of RCVS.<\/jats:p>","DOI":"10.3390\/diagnostics13172730","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T08:01:21Z","timestamp":1692777681000},"page":"2730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Headache Attributed to Reversible Cerebral Vasoconstriction Syndrome (RCVS)"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7899-7494","authenticated-orcid":false,"given":"Vasileios","family":"Tentolouris-Piperas","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loukas","family":"Lymperopoulos","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3276-588X","authenticated-orcid":false,"given":"Argyro","family":"Tountopoulou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Vassilopoulou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimos D.","family":"Mitsikostas","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/imj.12669","article-title":"Reversible cerebral vasoconstriction syndrome","volume":"45","author":"Calic","year":"2015","journal-title":"Intern. Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/01.STR.19.9.1159","article-title":"Reversible cerebral segmental vasoconstriction","volume":"19","author":"Call","year":"1988","journal-title":"Stroke"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/brain\/awm256","article-title":"The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients","volume":"130","author":"Ducros","year":"2007","journal-title":"Brain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7326\/0003-4819-146-1-200701020-00007","article-title":"Narrative review: Reversible cerebral vasoconstriction syndromes","volume":"146","author":"Calabrese","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S1474-4422(12)70135-7","article-title":"Reversible cerebral vasoconstriction syndrome","volume":"11","author":"Ducros","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ana.21951","article-title":"Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes","volume":"67","author":"Chen","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1001\/archneurol.2011.68","article-title":"Reversible cerebral vasoconstriction syndromes: Analysis of 139 cases","volume":"68","author":"Singhal","year":"2011","journal-title":"Arch. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jamaneurol.2013.4639","article-title":"Clinical worsening in reversible cerebral vasoconstriction syndrome","volume":"71","author":"Katz","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1212\/WNL.0000000000012223","article-title":"RCVS: Symptoms, Incidence, and Resource Utilization in a Population-Based US Cohort","volume":"97","author":"Omran","year":"2021","journal-title":"Neurology"},{"key":"ref_10","unstructured":"(2018). Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38, 1\u2013211."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e639","DOI":"10.1212\/WNL.0000000000006917","article-title":"RCVS(2) score and diagnostic approach for reversible cerebral vasoconstriction syndrome","volume":"92","author":"Rocha","year":"2019","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7750","DOI":"10.1038\/s41598-021-87412-7","article-title":"RCVS-TCH score can predict reversible cerebral vasoconstriction syndrome in patients with thunderclap headache","volume":"11","author":"Cho","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_13","first-page":"105906","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e00997","DOI":"10.1002\/brb3.997","article-title":"Prediction of vascular abnormalities on CT angiography in patients with acute headache","volume":"8","author":"Alons","year":"2018","journal-title":"Brain Behav."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jns.2017.01.056","article-title":"Reversible cerebral vasoconstriction syndrome in puerperium: A prospective study","volume":"375","author":"Anzola","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.11607\/ofph.1869","article-title":"Postpartum Headache: A Prospective Study","volume":"31","author":"Anzola","year":"2017","journal-title":"J. Oral. Facial Pain. Headache"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/STROKEAHA.119.027703","article-title":"Long-Term Outcomes after Reversible Cerebral Vasoconstriction Syndrome","volume":"51","author":"Boitet","year":"2020","journal-title":"Stroke"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1177\/0333102419849013","article-title":"The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)","volume":"39","author":"Caria","year":"2019","journal-title":"Cephalalgia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s10194-018-0906-7","article-title":"Vascular wall imaging in reversible cerebral vasoconstriction syndrome\u2014A 3-T contrast-enhanced MRI study","volume":"19","author":"Chen","year":"2018","journal-title":"J. Headache Pain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1001\/jamaneurol.2018.1321","article-title":"Dynamic Changes in White Matter Hyperintensities in Reversible Cerebral Vasoconstriction Syndrome","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/ana.21384","article-title":"Transcranial color doppler study for reversible cerebral vasoconstriction syndromes","volume":"63","author":"Chen","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1212\/WNL.0000000000001473","article-title":"Recurrence of reversible cerebral vasoconstriction syndrome: A long-term follow-up study","volume":"84","author":"Chen","year":"2015","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1129-2377-15-13","article-title":"A common cause of sudden and thunderclap headaches: Reversible cerebral vasoconstriction syndrome","volume":"15","author":"Cheng","year":"2014","journal-title":"J. Headache Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3389\/fneur.2019.00644","article-title":"Effect of Nimodipine Treatment on the Clinical Course of Reversible Cerebral Vasoconstriction Syndrome","volume":"10","author":"Cho","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/0333102417715223","article-title":"Characteristics and demographics of reversible cerebral vasoconstriction syndrome: A large prospective series of Korean patients","volume":"38","author":"Choi","year":"2018","journal-title":"Cephalalgia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s10194-017-0738-x","article-title":"Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: A case-control study","volume":"18","author":"Choi","year":"2017","journal-title":"J. Headache Pain"},{"key":"ref_27","first-page":"e16091","article-title":"Multifocal Atraumatic Convexity Subarachnoid Hemorrhage","volume":"13","author":"Dakay","year":"2021","journal-title":"Cureus"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e1468","DOI":"10.1212\/WNL.0000000000006367","article-title":"Primary angiitis of the CNS and reversible cerebral vasoconstriction syndrome: A comparative study","volume":"91","author":"Parienti","year":"2018","journal-title":"Neurology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1161\/STROKEAHA.109.572313","article-title":"Hemorrhagic manifestations of reversible cerebral vasoconstriction syndrome: Frequency, features, and risk factors","volume":"41","author":"Ducros","year":"2010","journal-title":"Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104473","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104473","article-title":"The Spectrum of Nontraumatic Convexity Subarachnoid Hemorrhage","volume":"28","author":"Forman","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e559","DOI":"10.1002\/ams2.559","article-title":"Reversible cerebral vasoconstriction syndrome: The importance of follow-up imaging within 2 weeks","volume":"7","author":"Fukaguchi","year":"2020","journal-title":"Acute Med. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e2912","DOI":"10.1212\/WNL.0000000000012107","article-title":"Early Risk of Readmission Following Hospitalization for Reversible Cerebral Vasoconstriction Syndrome","volume":"96","author":"Garg","year":"2021","journal-title":"Neurology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/ene.12926","article-title":"Distinguishing clinical and radiological features of non-traumatic convexal subarachnoid hemorrhage","volume":"23","author":"Fugate","year":"2016","journal-title":"Eur. J. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/head.12256","article-title":"How often is thunderclap headache caused by the reversible cerebral vasoconstriction syndrome?","volume":"54","author":"Grooters","year":"2014","journal-title":"Headache"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/jon.12946","article-title":"Transcranial Doppler findings in reversible cerebral vasoconstriction syndrome","volume":"32","author":"Hathidara","year":"2022","journal-title":"J. Neuroimaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/0333102415591507","article-title":"Long-term outcomes after reversible cerebral vasoconstriction syndrome","volume":"36","author":"John","year":"2016","journal-title":"Cephalalgia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.15441\/ceem.15.099","article-title":"Reversible cerebral vasoconstriction syndrome at the emergency department","volume":"2","author":"Kim","year":"2015","journal-title":"Clin. Exp. Emerg. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/cei.13148","article-title":"Cerebrospinal fluid findings in reversible cerebral vasoconstriction syndrome: A way to differentiate from cerebral vasculitis?","volume":"193","author":"Kraayvanger","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s00415-022-11511-2","article-title":"Vasoconstriction and long-term headache in reversible cerebral vasoconstriction syndrome","volume":"270","author":"Kumar","year":"2023","journal-title":"J. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1212\/WNL.0b013e3181d55efa","article-title":"Atraumatic convexal subarachnoid hemorrhage: Clinical presentation, imaging patterns, and etiologies","volume":"74","author":"Kumar","year":"2010","journal-title":"Neurology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"120441","DOI":"10.1016\/j.jns.2022.120441","article-title":"Persistent brain damage in reversible cerebral vasoconstriction syndrome on (99m)Tc-ethyl cysteinate dimer single-photon emission computed tomography: A long-term observational study","volume":"442","author":"Kunitake","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/ene.15064","article-title":"Type of headache at onset and risk for complications in reversible cerebral vasoconstriction syndrome","volume":"29","author":"Lange","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1007\/s00415-023-11708-z","article-title":"Complications of reversible cerebral vasoconstriction syndrome in relation to age","volume":"270","author":"Lange","year":"2023","journal-title":"J. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/ana.24891","article-title":"Blood-brain barrier breakdown in reversible cerebral vasoconstriction syndrome: Implications for pathophysiology and diagnosis","volume":"81","author":"Lee","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1177\/0333102417744361","article-title":"Serial testing of the ICHD-3 beta diagnostic criteria for probable reversible cerebral vasoconstriction syndrome: A prospective validation study","volume":"38","author":"Lee","year":"2018","journal-title":"Cephalalgia"},{"key":"ref_46","first-page":"38","article-title":"Transcranial Doppler Ultrasonography As a Non-Invasive Tool for Diagnosis and Monitoring of Reversible Cerebral Vasoconstriction Syndrome","volume":"99","author":"Levin","year":"2016","journal-title":"Rhode Isl. Med. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1177\/03331024211028965","article-title":"Diagnosis and classification of headache associated with sexual activity using a composite algorithm: A cohort study","volume":"41","author":"Lin","year":"2021","journal-title":"Cephalalgia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s10194-021-01223-9","article-title":"Post-reversible cerebral vasoconstriction syndrome headache","volume":"22","author":"Ling","year":"2021","journal-title":"J. Headache Pain"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neurol.2013.07.032","article-title":"Subarachnoid and intra-cerebral hemorrhage in young adults: Rare and underdiagnosed","volume":"170","author":"Mathon","year":"2014","journal-title":"Rev. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1212\/WNL.0b013e3182a2cbe2","article-title":"Reversible cerebral vasoconstriction syndrome and cervical artery dissection in 20 patients","volume":"81","author":"Mawet","year":"2013","journal-title":"Neurology"},{"key":"ref_51","first-page":"1254","article-title":"Differentiating reversible cerebral vasoconstriction syndrome with subarachnoid hemorrhage from other causes of subarachnoid hemorrhage","volume":"70","author":"Muehlschlegel","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3899\/jrheum.110707","article-title":"Challenging the diagnosis of primary angiitis of the central nervous system: A single-center retrospective study","volume":"39","author":"Guillon","year":"2012","journal-title":"J. Rheumatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s00415-020-10193-y","article-title":"Hemorrhagic reversible cerebral vasoconstriction syndrome: A retrospective observational study","volume":"268","author":"Patel","year":"2021","journal-title":"J. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/head.12197","article-title":"Headache as a crucial symptom in the etiology of convexal subarachnoid hemorrhage","volume":"54","author":"Rico","year":"2014","journal-title":"Headache"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/head.13504","article-title":"Influence of Climate on the Incidence of RCVS\u2014A Retrospective Study from Taiwan","volume":"59","author":"Shih","year":"2019","journal-title":"Headache"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3174\/ajnr.A4768","article-title":"Centripetal Propagation of Vasoconstriction at the Time of Headache Resolution in Patients with Reversible Cerebral Vasoconstriction Syndrome","volume":"37","author":"Shimoda","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1177\/0333102418762471","article-title":"Clinical significance of centripetal propagation of vasoconstriction in patients with reversible cerebral vasoconstriction syndrome: A retrospective case-control study","volume":"38","author":"Shimoda","year":"2018","journal-title":"Cephalalgia"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1212\/WNL.0000000000003510","article-title":"Glucocorticoid-associated worsening in reversible cerebral vasoconstriction syndrome","volume":"88","author":"Singhal","year":"2017","journal-title":"Neurology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/ana.24652","article-title":"Reversible cerebral vasoconstriction syndromes and primary angiitis of the central nervous system: Clinical, imaging, and angiographic comparison","volume":"79","author":"Singhal","year":"2016","journal-title":"Ann. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/head.14072","article-title":"Characterization of thunderclap headache in a reversible cerebral vasoconstriction syndrome case series","volume":"61","author":"Smith","year":"2021","journal-title":"Headache"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s42466-022-00173-0","article-title":"Intra-arterial application of nimodipine in reversible cerebral vasoconstriction syndrome: A neuroradiological method to help differentiate from primary central nervous system vasculitis","volume":"4","author":"Strunk","year":"2022","journal-title":"Neurol. Res. Pract."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/0333102416650706","article-title":"Cerebral vasomotor reactivity in reversible cerebral vasoconstriction syndrome","volume":"37","author":"Topcuoglu","year":"2017","journal-title":"Cephalalgia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/0333102416637826","article-title":"Coexisting vascular lesions in reversible cerebral vasoconstriction syndrome","volume":"37","author":"Topcuoglu","year":"2017","journal-title":"Cephalalgia"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/2396987316656981","article-title":"Gender and hormonal influences in reversible cerebral vasoconstriction syndrome","volume":"1","author":"Topcuoglu","year":"2016","journal-title":"Eur. Stroke J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/STROKEAHA.116.013136","article-title":"Hemorrhagic Reversible Cerebral Vasoconstriction Syndrome: Features and Mechanisms","volume":"47","author":"Topcuoglu","year":"2016","journal-title":"Stroke"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1468-2982.2008.01541.x","article-title":"Bath-related thunderclap headache: A study of 21 consecutive patients","volume":"28","author":"Wang","year":"2008","journal-title":"Cephalalgia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000369776","article-title":"Ischaemic strokes with reversible vasoconstriction and without thunderclap headache: A variant of the reversible cerebral vasoconstriction syndrome?","volume":"39","author":"Wolff","year":"2015","journal-title":"Cerebrovasc. Dis."},{"key":"ref_68","unstructured":"(2004). The International Classification of Headache Disorders: 2nd edition. Cephalalgia, 24, 9\u2013160."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/1756285610361795","article-title":"Reversible cerebral vasoconstriction syndrome: An under-recognized clinical emergency","volume":"3","author":"Chen","year":"2010","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/head.12794","article-title":"Reversible Cerebral Vasoconstriction Syndrome without Typical Thunderclap Headache","volume":"56","author":"Wolff","year":"2016","journal-title":"Headache"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/head.12797","article-title":"The Typical Thunderclap Headache of Reversible Cerebral Vasoconstriction Syndrome and Its Various Triggers","volume":"56","author":"Ducros","year":"2016","journal-title":"Headache"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00415-022-11425-z","article-title":"RCVS: By clinicians for clinicians\u2013A narrative review","volume":"270","author":"Erhart","year":"2023","journal-title":"J. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3174\/ajnr.A4214","article-title":"Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical Course","volume":"36","author":"Miller","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1385\/NCC:3:1:091","article-title":"Postpartum angiopathy and other cerebral vasoconstriction syndromes","volume":"3","author":"Singhal","year":"2005","journal-title":"Neurocrit Care"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/1753495X19825699","article-title":"Neurovascular disorders in pregnancy: A review","volume":"12","author":"Roth","year":"2019","journal-title":"Obstet. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/STROKEAHA.111.639575","article-title":"Variable presentations of postpartum angiopathy","volume":"43","author":"Fugate","year":"2012","journal-title":"Stroke"},{"key":"ref_77","first-page":"3519","article-title":"Reversible cerebral vasoconstriction syndrome: A comprehensive systematic review","volume":"25","author":"Song","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.pediatrneurol.2012.10.005","article-title":"Cerebral vasoconstriction triggered by sympathomimetic drugs during intra-atrerial chemotherapy","volume":"48","author":"Abruzzo","year":"2013","journal-title":"Pediatr. Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1941874420953051","article-title":"Illicit Drugs and Reversible Cerebral Vasoconstriction Syndrome","volume":"11","author":"Short","year":"2021","journal-title":"Neurohospitalist"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s11547-022-01532-2","article-title":"Reversible cerebral vasoconstriction syndrome: Review of neuroimaging findings","volume":"127","author":"Perillo","year":"2022","journal-title":"Radiol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fneur.2020.00034","article-title":"Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: Clinical and Radiological Considerations","volume":"11","author":"Pilato","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/neurolint14020040","article-title":"Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis","volume":"14","author":"Pacheco","year":"2022","journal-title":"Neurol. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jns.2013.12.043","article-title":"Association between reversible cerebral vasoconstriction syndrome and thrombotic thrombocytopenic purpura","volume":"338","author":"Paliwal","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/art.10797","article-title":"Benign angiopathy of the central nervous system: Cohort of 16 patients with clinical course and long-term followup","volume":"47","author":"Furlan","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1129-2377-14-100","article-title":"New daily persistent headache with a thunderclap headache onset and complete response to nimodipine (a new distinct subtype of NDPH)","volume":"14","author":"Rozen","year":"2013","journal-title":"J. Headache Pain"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/head.13495","article-title":"An RCVS Spectrum Disorder? New Daily Persistent Headache Starting as a Single Thunderclap Headache (3 New Cases)","volume":"59","author":"Jamali","year":"2019","journal-title":"Headache"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11916-020-00908-1","article-title":"Narrative Review: Headaches After Reversible Cerebral Vasoconstriction Syndrome","volume":"24","author":"Ling","year":"2020","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1148\/rg.2019190017","article-title":"Acute Headache in the Emergency Setting","volume":"39","author":"Guryildirim","year":"2019","journal-title":"Radiographics"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41983-023-00607-9","article-title":"Reversible cerebral vasoconstriction syndrome: Literature review","volume":"59","author":"Ribas","year":"2023","journal-title":"Egypt. J. Neurol. Psychiatr. Neurosurg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.crad.2017.11.017","article-title":"Reversible cerebral vasoconstriction syndrome: An important and common cause of thunderclap and recurrent headaches","volume":"73","author":"Arrigan","year":"2018","journal-title":"Clin. Radiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pbj.2016.04.002","article-title":"Reversible cerebral vasoconstriction syndrome\u2014A narrative revision of the literature","volume":"1","author":"Santos","year":"2016","journal-title":"Porto Biomed. J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1161\/STROKEAHA.107.510107","article-title":"Postpartum cervicocephalic artery dissection","volume":"39","author":"Arnold","year":"2008","journal-title":"Stroke"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1161\/STROKEAHA.119.024416","article-title":"Reversible Cerebral Vasoconstriction Syndrome","volume":"50","author":"Burton","year":"2019","journal-title":"Stroke"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/head.14094","article-title":"Quantitative arterial spin labeling magnetic resonance imaging analysis of reversible cerebral vasoconstriction syndrome: A case series","volume":"61","author":"Kano","year":"2021","journal-title":"Headache"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neurol.2021.06.015","article-title":"Transcranial Doppler findings in a population with clinical probable reversible cerebral vasoconstriction syndrome","volume":"178","author":"Oliveira","year":"2022","journal-title":"Rev. Neurol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1177\/0333102414529193","article-title":"Hyperintense vessels: An early MRI marker of reversible cerebral vasoconstriction syndrome?","volume":"34","author":"Chen","year":"2014","journal-title":"Cephalalgia"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.rcl.2019.07.001","article-title":"Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: Distinct Clinical Entities with Overlapping Pathophysiology","volume":"57","author":"Levitt","year":"2019","journal-title":"Radiol. Clin. North. Am."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"100936","DOI":"10.1016\/j.spen.2021.100936","article-title":"Reversible cerebral vasoconstriction syndrome in children: An update","volume":"40","author":"Fryer","year":"2021","journal-title":"Semin. Pediatr. Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.braindev.2016.04.006","article-title":"Reversible cerebral vasoconstriction syndrome manifesting as focal seizures without a thunderclap headache: A pediatric case report","volume":"38","author":"Kuga","year":"2016","journal-title":"Brain Dev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pediatrneurol.2018.10.022","article-title":"Reversible Cerebral Vasoconstriction Syndrome: A Novel Mechanism for Neurological Complications in Schimke Immuno-Osseous Dysplasia","volume":"92","author":"Haffner","year":"2019","journal-title":"Pediatr. Neurol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.radcr.2020.02.025","article-title":"Fear the reaper: Reversible cerebrovascular vasoconstriction syndrome after hot pepper ingestion","volume":"15","author":"Taylor","year":"2020","journal-title":"Radiol. Case Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pediatrneurol.2021.03.008","article-title":"A Rare Pediatric Case of Marijuana-Induced Reversible Cerebral Vasoconstriction Syndrome","volume":"120","author":"Bliss","year":"2021","journal-title":"Pediatr. Neurol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"291.e5","DOI":"10.1016\/j.ajem.2020.10.024","article-title":"Posterior reversible encephalopathy syndrome associated with Henoch Schonlein Purpura in a pediatric patient","volume":"43","author":"Fikse","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1212\/CPJ.0000000000200069","article-title":"Reversible Cerebral Vasoconstriction Syndrome in a Previously Healthy Child: A Case Report","volume":"12","author":"Manuel","year":"2022","journal-title":"Neurol. Clin. Pract."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pediatrneurol.2021.12.013","article-title":"Reversible Cerebral Vasoconstriction Syndrome and Multisystem Inflammatory Syndrome in Children with COVID-19","volume":"129","author":"Sadeghizadeh","year":"2022","journal-title":"Pediatr. Neurol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1042509","DOI":"10.3389\/fped.2023.1042509","article-title":"Intra-arterial vasodilators infusion for management of reversible cerebral vasoconstriction syndrome in a 12-year-old girl: A case report","volume":"11","author":"Rizzati","year":"2023","journal-title":"Front. Pediatr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1017\/S0317167100005096","article-title":"A pediatric case of reversible segmental cerebral vasoconstriction","volume":"33","author":"Kirton","year":"2006","journal-title":"Can J. Neurol. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1468-2982.2009.01955.x","article-title":"Three paediatric patients with reversible cerebral vasoconstriction syndromes","volume":"30","author":"Liu","year":"2010","journal-title":"Cephalalgia"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1469-8749.2012.04433.x","article-title":"Reversible cerebral vasoconstriction syndrome: Rare or underrecognized in children?","volume":"55","author":"Probert","year":"2013","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.pediatrneurol.2015.02.015","article-title":"Reversible vasoconstriction syndrome involving the basilar artery in an adolescent: Imaging and clinical features","volume":"52","author":"Guerriero","year":"2015","journal-title":"Pediatr. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/0883073817696817","article-title":"Reversible Cerebral Vasoconstriction Syndrome in Pediatrics: A Case Series and Review","volume":"32","author":"Coffino","year":"2017","journal-title":"J. Child Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pediatrneurol.2017.02.008","article-title":"A Pediatric Case of Reversible Cerebral Vasoconstriction Syndrome with Similar Radiographic Findings to Posterior Reversible Encephalopathy Syndrome","volume":"71","author":"Kamide","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.braindev.2011.11.001","article-title":"Reversible cerebral vasoconstriction syndrome associated with brain parenchymal hemorrhage","volume":"34","author":"Kazato","year":"2012","journal-title":"Brain Dev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.4081\/hr.2016.6673","article-title":"Reversible Cerebral Vasoconstriction Syndrome Promptly Diagnosed with Magnetic Resonance Imaging Including Magnetic Resonance Angiography During Immunosuppressive Therapy in a 16-Year-Old Girl with Refractory Cytopenia of Childhood","volume":"8","author":"Ueki","year":"2016","journal-title":"Hematol. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jocn.2017.01.010","article-title":"Initial vasodilatation in a child with reversible cerebral vasoconstriction syndrome","volume":"39","author":"Oikawa","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"106118","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106118","article-title":"Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series","volume":"30","author":"Arandela","year":"2021","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"105011","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105011","article-title":"Reversible cerebral vasoconstriction syndrome and dissection in the setting of COVID-19 infection","volume":"29","author":"Dakay","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"105822","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105822","article-title":"COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin","volume":"30","author":"Mansoor","year":"2021","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_119","first-page":"e17408","article-title":"Intracerebral Hemorrhage and Reversible Cerebral Vasoconstriction Syndrome in a Patient with COVID-19","volume":"13","author":"Srinivasan","year":"2021","journal-title":"Cureus"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/NRL.0000000000000387","article-title":"Reversible Cerebral Vasoconstriction Syndrome in the Setting of COVID-19 and Pleomorphic Sarcoma: A Case Report","volume":"27","author":"Harahsheh","year":"2022","journal-title":"Neurologist"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"106238","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106238","article-title":"Fulminant Reversible Cerebral Vasoconstriction Syndrome in Breakthrough COVID-19 Infection","volume":"31","author":"Ray","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"101437","DOI":"10.1016\/j.inat.2021.101437","article-title":"Case report of a fulminant non-aneurysmal convexity subarachnoid hemorrhage after COVID-19","volume":"27","author":"Scheer","year":"2022","journal-title":"Interdiscip. Neurosurg."},{"key":"ref_123","unstructured":"(2023, June 25). COVID-19 mRNA Pfizer-BioNTech Vaccine Analysis Print, Available online: https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/1072043\/COVID-19_mRNA_Pfizer-_BioNTech_vaccine_analysis_print.pdf."},{"key":"ref_124","first-page":"e19987","article-title":"First Reported Case of Reversible Cerebral Vasoconstriction Syndrome after a SARS-CoV-2 Vaccine","volume":"13","author":"Finsterer","year":"2021","journal-title":"Cureus"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Lund, A.M., and Al-Karagholi, M.A. (2022). COVID-19 Vaccination Might Induce Reversible Cerebral Vasoconstriction Syndrome Attacks: A Case Report. Vaccines, 10.","DOI":"10.3390\/vaccines10050823"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/head.12798","article-title":"The Link Between Migraine, Reversible Cerebral Vasoconstriction Syndrome and Cervical Artery Dissection","volume":"56","author":"Mawet","year":"2016","journal-title":"Headache"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.25965","article-title":"Circulating microRNAs Associated with Reversible Cerebral Vasoconstriction Syndrome","volume":"89","author":"Chen","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Lange, K.S., Choi, S.Y., Ling, Y.H., Chen, S.P., Mawet, J., Duflos, C., Lee, M.J., Ducros, A., Wang, S.J., and Pezzini, A. (2023). Reversible cerebral Vasoconstriction syndrome intERnational CollaborativE (REVERCE) network: Study protocol and rationale of a multicentre research collaboration. Eur. Stroke J.","DOI":"10.1177\/23969873231182207"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/17\/2730\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:39:55Z","timestamp":1760128795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/17\/2730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":128,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["diagnostics13172730"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13172730","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,22]]}}}