{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:08:50Z","timestamp":1791353330583,"version":"4.3.1"},"reference-count":82,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Sleep disturbances are common in various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington\u2019s disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB). This article reviews the prevalence and characteristics of sleep disorders in these conditions, highlighting their impact on patients\u2019 quality of life and disease progression. Sleep-related breathing disorders, insomnia, restless legs syndrome (RLS), periodic limb movement syndrome (PLMS), and rapid eye movement sleep behavior disorder (RBD) are among the common sleep disturbances reported. Both pharmacological and non-pharmacological interventions play crucial roles in managing sleep disturbances and enhancing overall patient care.<\/jats:p>","DOI":"10.3390\/diagnostics13182898","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:05:17Z","timestamp":1694423117000},"page":"2898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Sleep Disorders Associated with Neurodegenerative Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Lucre\u021bia","family":"Anghel","sequence":"first","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800008 Galati, Romania"},{"name":"\u2018Sf. Apostol Andrei\u2019 Clinical Emergency County Hospital, 800578 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-3702","authenticated-orcid":false,"given":"Anamaria","family":"Ciubar\u0103","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurel","family":"Nechita","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800008 Galati, Romania"},{"name":"\u2018Sf. Ioan\u2019 Clinical Hospital for Children, 800487 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Nechita","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800008 Galati, Romania"},{"name":"\u2018Sf. Apostol Andrei\u2019 Clinical Emergency County Hospital, 800578 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Manole","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800008 Galati, Romania"},{"name":"\u2018Sf. Apostol Andrei\u2019 Clinical Emergency County Hospital, 800578 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-8435","authenticated-orcid":false,"given":"Liliana","family":"Baroiu","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800008 Galati, Romania"},{"name":"\u2018Sf. Cuv. Parascheva\u2019 Clinical Hospital of Infectious Diseases, 800179 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-6002","authenticated-orcid":false,"given":"Alexandru Bogdan","family":"Ciubar\u0103","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, Dunarea de Jos\u2019 University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina Liana","family":"Mu\u0219at","sequence":"additional","affiliation":[{"name":"\u2018Sf. 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Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"ITC33","DOI":"10.7326\/AITC202103160","article-title":"Insomnia","volume":"174","author":"Sutton","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Herrero Babiloni, A., and Baril, A.-A. (2023). The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12051793"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/npp.2017.294","article-title":"Neuronal Mechanisms for Sleep\/Wake Regulation and Modulatory Drive","volume":"43","author":"Appelbaum","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/497S2a","article-title":"Structure: The Anatomy of Sleep","volume":"497","author":"Peplow","year":"2013","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41583-018-0026-z","article-title":"Generation of Circadian Rhythms in the Suprachiasmatic Nucleus","volume":"19","author":"Hastings","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.cub.2011.10.052","article-title":"REM Sleep Depotentiates Amygdala Activity to Previous Emotional Experiences","volume":"21","author":"Yao","year":"2011","journal-title":"Curr. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1152\/physrev.00032.2011","article-title":"Control of Sleep and Wakefulness","volume":"92","author":"Brown","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nature06041","article-title":"Behavioural Improvements with Thalamic Stimulation after Severe Traumatic Brain Injury","volume":"448","author":"Schiff","year":"2007","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JAD-2010-1379","article-title":"Caffeine and Adenosine","volume":"20","author":"Ribeiro","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/NSS.S62907","article-title":"Causes and Consequences of Sleepiness among College Students","volume":"2014","author":"Hershner","year":"2014","journal-title":"NSS"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nbscr.2018.02.003","article-title":"Sleep Homeostasis and the Circadian Clock: Do the Circadian Pacemaker and the Sleep Homeostat Influence Each Other\u2019s Functioning?","volume":"5","author":"Deboer","year":"2018","journal-title":"Neurobiol. Sleep Circadian Rhythm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20190098","DOI":"10.1098\/rsfs.2019.0098","article-title":"Sleep, Circadian Rhythms and Health","volume":"10","author":"Foster","year":"2020","journal-title":"Interface Focus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0748730406294627","article-title":"Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback","volume":"21","author":"Fuller","year":"2006","journal-title":"J. Biol. Rhythm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2337\/diaspect.29.1.5","article-title":"Physiology of Sleep","volume":"29","author":"Carley","year":"2016","journal-title":"Diabetes Spectr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1880-6805-31-14","article-title":"Effects of Thermal Environment on Sleep and Circadian Rhythm","volume":"31","author":"Mizuno","year":"2012","journal-title":"J. Physiol. Anthr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41386-019-0478-5","article-title":"Bidirectional Relationship between Sleep and Alzheimer\u2019s Disease: Role of Amyloid, Tau, and Other Factors","volume":"45","author":"Wang","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"101250","DOI":"10.1016\/j.smrv.2019.101250","article-title":"Obstructive Sleep Apnea, Cognition and Alzheimer\u2019s Disease: A Systematic Review Integrating Three Decades of Multidisciplinary Research","volume":"50","author":"Bubu","year":"2020","journal-title":"Sleep Med. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1007\/s00415-019-09286-0","article-title":"Association between Sleep Disturbance in Alzheimer\u2019s Disease Patients and Burden on and Health Status of Their Caregivers","volume":"266","author":"Okuda","year":"2019","journal-title":"J. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/JGP.0b013e3180381521","article-title":"Daytime Sleepiness and Functional Impairment in Alzheimer Disease","volume":"15","author":"Lee","year":"2007","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13311-012-0143-8","article-title":"Parasomnias: An Updated Review","volume":"9","author":"Howell","year":"2012","journal-title":"Neurotherapeutics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.sleep.2020.05.029","article-title":"The Sleep Side of Aging and Alzheimer\u2019s Disease","volume":"77","author":"Romanella","year":"2021","journal-title":"Sleep Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1212\/WNL.0000000000002542","article-title":"Restless Legs Syndrome Associated with Major Diseases: A Systematic Review and New Concept","volume":"86","author":"Trenkwalder","year":"2016","journal-title":"Neurology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/NSS.S76706","article-title":"Clinical Management of Sleep Disturbances in Alzheimer&#39;s Disease: Current and Emerging Strategies","volume":"8","author":"Urrestarazu","year":"2016","journal-title":"NSS"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jad.2016.02.060","article-title":"The Prevalence and Predictors of Obstructive Sleep Apnea in Major Depressive Disorder, Bipolar Disorder and Schizophrenia: A Systematic Review and Meta-Analysis","volume":"197","author":"Stubbs","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.sleep.2012.10.015","article-title":"Clinicopathologic Correlations in 172 Cases of Rapid Eye Movement Sleep Behavior Disorder with or without a Coexisting Neurologic Disorder","volume":"14","author":"Boeve","year":"2013","journal-title":"Sleep Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smrv.2017.06.010","article-title":"Sleep Disturbances Increase the Risk of Dementia: A Systematic Review and Meta-Analysis","volume":"40","author":"Shi","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S1474-4422(06)70476-8","article-title":"Rapid-Eye-Movement Sleep Behaviour Disorder as an Early Marker for a Neurodegenerative Disorder: A Descriptive Study","volume":"5","author":"Iranzo","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1136\/jnnp.2008.149195","article-title":"REM Sleep Behaviour Disorder in Parkinson\u2019s Disease Is Associated with Specific Motor Features","volume":"79","author":"Postuma","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mdc3.12582","article-title":"Is It Useful to Classify Progressive Supranuclear Palsy and Corticobasal Degeneration as Different Disorders? No","volume":"5","year":"2018","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Paoli, R., and Botturi, A. (2017). Neuropsychiatric Burden in Huntington\u2019s Disease. Brain Sci., 7.","DOI":"10.3390\/brainsci7060067"},{"key":"ref_33","first-page":"e24473","article-title":"The Effect of Huntington\u2019s Disease on the Basal Nuclei: A Review","volume":"14","author":"Matz","year":"2022","journal-title":"Cureus"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.5665\/sleep.4996","article-title":"Polysomnographic Findings and Clinical Correlates in Huntington Disease: A Cross-Sectional Cohort Study","volume":"38","author":"Piano","year":"2015","journal-title":"Sleep"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Galatolo, D., and De Michele, G. (2021). NGS in Hereditary Ataxia: When Rare Becomes Frequent. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168490"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"125273","DOI":"10.1155\/2015\/125273","article-title":"Parkinsonism in Spinocerebellar Ataxia","volume":"2015","author":"Park","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5664\/jcsm.7592","article-title":"Occurrence of Stridor During Sleep in a Patient with Spinocerebellar Ataxia Type 17","volume":"15","author":"Kim","year":"2019","journal-title":"J. Clin. Sleep Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"a024117","DOI":"10.1101\/cshperspect.a024117","article-title":"Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS)","volume":"7","author":"Grad","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1212\/WNL.0000000000003037","article-title":"Role of Sleep-Disordered Breathing and Sleep-Wake Disturbances for Stroke and Stroke Recovery","volume":"87","author":"Hermann","year":"2016","journal-title":"Neurology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1212\/CPJ.0000000000000320","article-title":"Treatment Options for Obstructive Sleep Apnea","volume":"7","author":"Pavwoski","year":"2017","journal-title":"Neurol. Clin. Pract."},{"key":"ref_41","unstructured":"Gong, Y., and Sankari, A. (2023). StatPeratls, StatPearls Publishing."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"175346662311659","DOI":"10.1177\/17534666231165914","article-title":"Long-Term Home Mechanical Ventilation Using a Noninvasive Ventilator via Tracheotomy in Patients with Myasthenia Gravis: A Case Report and Literature Review","volume":"17","author":"Liu","year":"2023","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11910-020-01047-1","article-title":"Sleep and Sleep Disruption in Amyotrophic Lateral Sclerosis","volume":"20","author":"Boentert","year":"2020","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.14336\/AD.2019.0324","article-title":"Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update","volume":"11","author":"Zhang","year":"2020","journal-title":"Aging Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0299-y","article-title":"Models of Multiple System Atrophy","volume":"51","author":"Lee","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1007\/s00415-020-09881-6","article-title":"An Update on MSA: Premotor and Non-Motor Features Open a Window of Opportunities for Early Diagnosis and Intervention","volume":"267","author":"Chelban","year":"2020","journal-title":"J. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/mds.26918","article-title":"Management of Sleep Disorders in Parkinson\u2019s Disease and Multiple System Atrophy: Sleep In PD and MSA","volume":"32","author":"Videnovic","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"677213","DOI":"10.3389\/fneur.2021.677213","article-title":"REM Sleep Behaviour Disorder in Multiple System Atrophy: From Prodromal to Progression of Disease","volume":"12","author":"Giannini","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Koo, D.L., and Lee, J.Y. (2016). Acoustic Characteristics of Stridor in Multiple System Atrophy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153935"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.autneu.2017.10.007","article-title":"Diagnosis of Multiple System Atrophy","volume":"211","author":"Palma","year":"2018","journal-title":"Auton. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1212\/WNL.0000000000008208","article-title":"Stridor in Multiple System Atrophy: Consensus Statement on Diagnosis, Prognosis, and Treatment","volume":"93","author":"Cortelli","year":"2019","journal-title":"Neurology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/MCP.0000000000000725","article-title":"Respiratory and Sleep-Related Complications of Multiple System Atrophy","volume":"26","author":"Ralls","year":"2020","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1590\/0004-282x20190149","article-title":"Alzheimer\u2019s Disease and Sleep Disturbances: A Review","volume":"77","author":"Borges","year":"2019","journal-title":"Arq. Neuro-Psiquiatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"105054","DOI":"10.1016\/j.nbd.2020.105054","article-title":"Obstructive Sleep Apnea and Its Treatment in Aging: Effects on Alzheimer\u2019s Disease Biomarkers, Cognition, Brain Structure and Neurophysiology","volume":"145","author":"Mullins","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Casagrande, M., and Forte, G. (2022). Sleep Quality and Aging: A Systematic Review on Healthy Older People, Mild Cognitive Impairment and Alzheimer\u2019s Disease. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19148457"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e2488","DOI":"10.1002\/brb3.2488","article-title":"Effects of Eszopiclone on Sleep Quality and Cognitive Function in Elderly Patients with Alzheimer\u2019s Disease and Sleep Disorder: A Randomized Controlled Trial","volume":"12","author":"Huo","year":"2022","journal-title":"Brain Behav."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41386-021-01191-3","article-title":"The Efficacy and Safety of Zolpidem and Zopiclone to Treat Insomnia in Alzheimer\u2019s Disease: A Randomized, Triple-Blind, Placebo-Controlled Trial","volume":"47","author":"Louzada","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Przybylska-Ku\u0107, S., and Zakrzewski, M. (2019). Obstructive Sleep Apnea May Increase the Risk of Alzheimer\u2019s Disease. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221255"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3233\/JAD-215417","article-title":"The Role of Amyloid, Tau, and APOE Genotype on the Relationship Between Informant-Reported Sleep Disturbance and Alzheimer\u2019s Disease Risks","volume":"87","author":"Kim","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9421098","DOI":"10.1155\/2018\/9421098","article-title":"REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)","volume":"2018","author":"Chan","year":"2018","journal-title":"Behav. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"101782","DOI":"10.1016\/j.arr.2022.101782","article-title":"Prevalence of Sleep Disturbances in People with Dementia Living in the Community: A Systematic Review and Meta-Analysis","volume":"83","author":"Koren","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/WNL.0000000000003887","article-title":"Clinical Manifestations of the Anti-IgLON5 Disease","volume":"88","author":"Gaig","year":"2017","journal-title":"Neurology"},{"key":"ref_63","first-page":"118","article-title":"The Non-Motor Symptom Profile of Progressive Supranuclear Palsy","volume":"13","author":"Chaithra","year":"2020","journal-title":"J. Mov. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/pgmj.72.847.293","article-title":"Nocturnal and Respiratory Disturbances in Steele-Richardson-Olszewski Syndrome (Progressive Supranuclear Palsy)","volume":"72","author":"Machado","year":"1996","journal-title":"Postgrad. Med. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1474-4422(14)70051-1","article-title":"A Novel Non-Rapid-Eye Movement and Rapid-Eye-Movement Parasomnia with Sleep Breathing Disorder Associated with Antibodies to IgLON5: A Case Series, Characterisation of the Antigen, and Post-Mortem Study","volume":"13","author":"Sabater","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/NRL.0b013e31827c6bdd","article-title":"Polysomnographic Findings in Dementia with Lewy Bodies","volume":"19","author":"Pao","year":"2013","journal-title":"Neurologist"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"zsz154","DOI":"10.1093\/sleep\/zsz154","article-title":"Sleep in Huntington\u2019s Disease: A Systematic Review and Meta-Analysis of Polysomongraphic Findings","volume":"42","author":"Zhang","year":"2019","journal-title":"Sleep"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Maffi, S., and Scaricamazza, E. (2022). Sleep Quality and Related Clinical Manifestations in Huntington Disease. J. Personal. Med., 12.","DOI":"10.3390\/jpm12060864"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/brain\/awz030","article-title":"Risk and Predictors of Dementia and Parkinsonism in Idiopathic REM Sleep Behaviour Disorder: A Multicentre Study","volume":"142","author":"Postuma","year":"2019","journal-title":"Brain"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/jamaneurol.2018.4377","article-title":"Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease","volume":"76","author":"Lees","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/acn3.51738","article-title":"Baseline Characteristics of the North American Prodromal Synucleinopathy Cohort","volume":"10","author":"Elliott","year":"2023","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13023-019-1079-4","article-title":"Evaluation of the Frequency of Non-Motor Symptoms of Parkinson\u2019s Disease in Adult Patients with Gaucher Disease Type 1","volume":"14","author":"Wilke","year":"2019","journal-title":"Orphanet. J. Rare Dis."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4088\/PCC.v03n0303","article-title":"Medications for the Treatment of Sleep Disorders: An Overview","volume":"3","author":"Pagel","year":"2001","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/14737175.2023.2214316","article-title":"Pharmacological and Non-Pharmacological Treatment Options for Sleep Disturbances in Alzheimer\u2019s Disease","volume":"23","author":"Javed","year":"2023","journal-title":"Expert Rev. Neurother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/1559827619867677","article-title":"Cognitive-Behavioral Therapy for Insomnia: An Effective and Underutilized Treatment for Insomnia","volume":"13","author":"Rossman","year":"2019","journal-title":"Am. J. Lifestyle Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/S1980-57642015DN91000003","article-title":"Obstructive Sleep Apnea and Neurodegenerative Diseases: A Bidirectional Relation","volume":"9","author":"Bahia","year":"2015","journal-title":"Dement. Neuropsychol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2217\/nmt-2016-0060","article-title":"Light, Sleep and Circadian Rhythms in Older Adults with Alzheimer\u2019s Disease and Related Dementias","volume":"7","author":"Figueiro","year":"2017","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3399\/bjgp23X731721","article-title":"REM Sleep Behaviour Disorder: The Importance of Early Identification in Primary Care","volume":"73","author":"Bramich","year":"2023","journal-title":"Br. J. Gen. Pract."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s13311-021-01019-4","article-title":"Restless Legs Syndrome: Contemporary Diagnosis and Treatment","volume":"18","author":"Gossard","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"a033118","DOI":"10.1101\/cshperspect.a033118","article-title":"Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases","volume":"10","author":"Erkkinen","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5664\/jcsm.4468","article-title":"Spectrum of Sleep Disorders in a Patient with Spinocerebellar Ataxia 13","volume":"11","author":"Kapoor","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fpsyt.2019.00221","article-title":"Sleep Disorders in Huntington\u2019s Disease","volume":"10","author":"Krzywoszanski","year":"2019","journal-title":"Front. 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