{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:10:25Z","timestamp":1790356225996,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The aim of our study was to evaluate the diagnostic capacity of the tear meniscus osmolarity measurement for dry eye disease (DED) in patients with rheumatoid arthritis (RA), using a portable osmometer based on electrical impedance and an integrated circuit technology (TearLab\u00ae (Escondido, CA, USA)). Methods: We included 101 RA patients, 81 patients with DED and 20 without DED (controls). We measured tear osmolarity and assessed other clinical diagnostic tests as suggested by the TFOS DEWS II composite reference standard diagnostic criteria for DED using Ocular Surface Disease Index (OSDI), Five-item Dry Eye Questionnaire (DEQ-5), fluorescein tear break-up time (F-TUBT), ocular surface staining (SICCA score), and other clinical parameters to classify DED subtypes. We analyzed the agreement between osmolarity and the TFOS DEWS II composite reference standard for DED diagnosis. We conducted receiver operating characteristic (ROC) curve analyses using the DED variable and its subtypes as dependent variables and the continuous variable for osmolarity or the inter-eye difference in osmolarity as independent variable. Sensitivity, specificity, and area under the curve for all potential cut-off points were obtained and reported from ROC curves. Results: We found that tear meniscus osmolarity had a low diagnostic capacity for DED (AUC = 0.57). Tear meniscus osmolarity measurement had a sensitivity of 35% and a specificity of 80% with a kappa level of agreement of 0.08 compared to the TFOS DEWS II composite reference standard. The low diagnostic capacity of the tear meniscus osmolarity was similar for aqueous-deficient DED and for evaporative DED, being only fair for severe DED with a 57% sensitivity and 80% specificity and a kappa level of agreement of 0.36. Conclusions: Our findings suggest that in patients with RA, tear meniscus osmolarity measured by the TearLab\u00ae showed low sensitivity, low specificity, and limited agreement with the TFOS DEWS II composite reference standard for DED diagnosis.<\/jats:p>","DOI":"10.3390\/diagnostics13182994","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T02:47:52Z","timestamp":1695091672000},"page":"2994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Performance of the Tear Meniscus Osmolarity Measurement for Dry Eye Disease in Rheumatoid Arthritis Patients"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-7142","authenticated-orcid":false,"given":"Paola","family":"De La Parra-Colin","sequence":"first","affiliation":[{"name":"Cornea and Ocular Surface Clinic, Department of Ophthalmology, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Ministry of Health, Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Palacios-Aguirre","sequence":"additional","affiliation":[{"name":"Cornea and Ocular Surface Clinic, Department of Ophthalmology, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Ministry of Health, Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Perez-Pria-Kasusky","sequence":"additional","affiliation":[{"name":"Cornea and Ocular Surface Clinic, Department of Ophthalmology, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Ministry of Health, Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Espinosa-Morales","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Ministry of Health, Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-8784","authenticated-orcid":false,"given":"Alberto","family":"Hidalgo-Bravo","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Ministry of Health, Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5606\/tjr.2011.002","article-title":"Diagnostic Accuracy of the 2002 EULAR Criteria for the Clinical Suspicion of Rheumatoid Arthritis and the Sensitivity of the New 2010 ACR\/EULAR Classification Criteria in \u201cEarly Arthritis\u201d","volume":"26","author":"Sizova","year":"2011","journal-title":"Turk. 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