{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:15:16Z","timestamp":1772720116573,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing medical scientific research project","award":["2023QNXM029"],"award-info":[{"award-number":["2023QNXM029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Purpose: To characterize the magnetic resonance imaging features of primary intrahepatic lymphoepithelioma-like cholangiocarcinoma (LELCC). Materials and Methods: Thirty-four patients with 38 histologically confirmed LELCCs were enrolled retrospectively from January 2014 to August 2022. We evaluated the clinical features, histologic findings, and imaging manifestations on dynamic enhanced MRI. Results: 74% (25\/34) of the cases were associated with EBV infection. Moreover, patients infected with EBV exhibited a lower level of Ki-67 proliferation. The serum CA199 level was elevated in 10 patients. The median tumor diameter was 2.8 cm (range, 1.1\u20138.7 cm). Most tumors were well-defined with a smooth or lobulated margin and showed peripheral hyperintensity and central hypointensity on T2-weighted imaging (T2WI). T2 hyperintense foci were recognized in 8 patients. In the dynamic enhanced MRI, 21 tumors demonstrated Type A enhancement pattern (rim enhancement), 10 demonstrated Type B (rapid wash-in and wash-out), and seven demonstrated Type C (rapid wash-in without wash-out). Capsular enhancement in PVP or DP was found in 22 tumors. A few patients had satellite lesions, portal vein thrombosis, bile duct dilatation, and distal metastasis. Lymph node metastases were discovered pathologically in 11 patients. Conclusions: MRI findings of LELCC vary and are non-specific. While a majority of LELCCs exhibit typical features of intrahepatic cholangiocarcinoma (iCCA), unique findings like T2 hyperintense foci or capsular enhancement could suggest LELCC. EBV infection and elevated tumor markers can aid in differentiation. However, given the mimics of some cases of liver hypervascular lesions, histological examination remains essential for definitive diagnosis.<\/jats:p>","DOI":"10.3390\/diagnostics13182998","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T01:32:50Z","timestamp":1695173570000},"page":"2998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The MR Imaging of Primary Intrahepatic Lymphoepithelioma-like Cholangiocarcinoma: A Diagnostic Challenge"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-569X","authenticated-orcid":false,"given":"Yangyang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai Geriatric Medical Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai Geriatric Medical Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengsu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Geriatric Medical Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Geriatric Medical Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/modpathol.3880342","article-title":"Intrahepatic cholangiocarcinoma with lymphoepithelioma-like component","volume":"14","author":"Chen","year":"2001","journal-title":"Mod. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hep.31102","article-title":"Lymphoepithelioma-Like Carcinomas: A Rare Variant of Cholangiocarcinoma","volume":"72","author":"Lin","year":"2020","journal-title":"Hepatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1148\/rg.293085729","article-title":"Varying appearances of cholangiocarcinoma: Radiologic-pathologic correlation","volume":"29","author":"Chung","year":"2009","journal-title":"Radiographics"},{"key":"ref_4","first-page":"172","article-title":"Lymphoepithelioma-like hepatocellular carcinoma","volume":"30","author":"Chen","year":"2007","journal-title":"Chang Gung Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/his.12455","article-title":"Epstein-Barr virus-associated lymphoepithelioma-like cholangiocarcinoma: A rare variant of intrahepatic cholangiocarcinoma with favourable outcome","volume":"65","author":"Chan","year":"2014","journal-title":"Histopathology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jhep.2020.10.037","article-title":"Clinicopathologic features, tumor immune microenvironment and genomic landscape of Epstein-Barr virus-associated intrahepatic cholangiocarcinoma","volume":"74","author":"Huang","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MCG.0000000000000456","article-title":"Lymphoepithelioma-like Cholangiocarcinoma: A Rare Finding with Good Outcomes","volume":"50","author":"Labgaa","year":"2016","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/his.14580","article-title":"Lymphoepithelioma-like neoplasm of the biliary tract with \u2018probable low malignant potential\u2019","volume":"80","author":"Khandakar","year":"2022","journal-title":"Histopathology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.3748\/wjg.v21.i13.4089","article-title":"Lymphoepithelioma-like cholangiocarcinoma: A mimic of hepatocellular carcinoma on imaging features","volume":"21","author":"Liao","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.21037\/atm.2019.08.105","article-title":"Lymphoepithelioma-like intrahepatic cholangiocarcinoma with Epstein-Barr virus infection: Report of a rare case","volume":"7","author":"Ding","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1445-2197.2011.05840.x","article-title":"Lymphoepithelioma-like cholangiocarcinoma not associated with Epstein-Barr virus","volume":"81","author":"Hur","year":"2011","journal-title":"ANZ J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4103\/0377-4929.168857","article-title":"Lymphoepithelioma-like hepatocellular carcinoma without Epstein-Barr virus infection: A case report and a review of the literature","volume":"58","author":"Wei","year":"2015","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s12328-020-01303-4","article-title":"Lymphoepithelioma-like cholangiocarcinoma with Epstein-Barr virus infection treated by radiofrequency ablation","volume":"14","author":"Nogami","year":"2021","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.1007\/s00330-023-09598-w","article-title":"Prognostic value of LI-RADS category on MRI in patients with primary hepatic lymphoepithelioma-like carcinoma","volume":"33","author":"Pan","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2214\/AJR.20.22937","article-title":"The CT and MRI Features of Primary Intrahepatic Lymphoepithelioma-Like Cholangiocarcinoma","volume":"216","author":"Yang","year":"2021","journal-title":"AJR. Am. J. Roentgenol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e5069","DOI":"10.1097\/MD.0000000000005069","article-title":"Clinicopathological features of 11 Epstein-Barr virus-associated intrahepatic cholangiocarcinoma at a single center in China","volume":"95","author":"Sun","year":"2016","journal-title":"Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000324485","article-title":"Intrahepatic lymphoepithelioma-like cholangiocarcinoma not associated with epstein-barr virus: A case report","volume":"4","author":"Lee","year":"2011","journal-title":"Case Rep. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13000-020-01035-6","article-title":"Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: A report of 3 cases and literature review","volume":"15","author":"Zhang","year":"2020","journal-title":"Diagn. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.9738\/INTSURG-D-14-00117.1","article-title":"Intrahepatic Cholangiocarcinoma With Lymphoepithelioma-like Carcinoma Components Not Associated With Epstein-Barr Virus: Report of a Case","volume":"100","author":"Aosasa","year":"2015","journal-title":"Int. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1007\/s00330-019-06030-0","article-title":"Problematic lesions in cirrhotic liver mimicking hepatocellular carcinoma","volume":"29","author":"Kim","year":"2019","journal-title":"Eur. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3346\/jkms.2017.32.2.315","article-title":"False Positive Diagnosis of Hepatocellular Carcinoma in Liver Resection Patients","volume":"32","author":"Lee","year":"2017","journal-title":"J. Korean Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1007\/s00330-017-4846-4","article-title":"Capsule, septum, and T2 hyperintense foci for differentiation between large hepatocellular carcinoma (>\/=5 cm) and intrahepatic cholangiocarcinoma on gadoxetic acid MRI","volume":"27","author":"Hwang","year":"2017","journal-title":"Eur. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.3748\/wjg.v21.i12.3472","article-title":"Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas","volume":"21","author":"Solinas","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_24","first-page":"913","article-title":"Hepatic epithelioid angiomyolipoma: Magnetic resonance imaging characteristics","volume":"48","author":"Junhao","year":"2023","journal-title":"Abdom. Radiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1148\/radiology.183.3.1316622","article-title":"Hepatocellular carcinoma: Correlation of MR imaging and histopathologic findings","volume":"183","author":"Kadoya","year":"1992","journal-title":"Radiology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3892\/ol_00000003","article-title":"Clinicopathological study of hepatocellular carcinoma with peliotic change","volume":"1","author":"Fujimoto","year":"2010","journal-title":"Oncol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"69749","DOI":"10.18632\/oncotarget.11949","article-title":"Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/00000478-200104000-00012","article-title":"Lymphoepithelioma-like cholangiocarcinoma: An Epstein-Barr virus-associated tumor","volume":"25","author":"Jeng","year":"2001","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e14206","DOI":"10.1097\/MD.0000000000014206","article-title":"Ultrasonographic findings of intrahepatic lymphoepithelioma-like cholangiocarcinoma associated with Epstein-Barr virus: Two cases report","volume":"98","author":"Ling","year":"2019","journal-title":"Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e229520","DOI":"10.1136\/bcr-2019-229520","article-title":"An EBV+ lymphoepithelioma-like cholangiocarcinoma in a young woman with chronic hepatitis B","volume":"12","author":"Gearty","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_31","first-page":"476","article-title":"Intrahepatic cholangiocarcinoma with lymphoepithelioma-like carcinoma component","volume":"34","author":"Huang","year":"2004","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pavicevic, S., Reichelt, S., Uluk, D., Lurje, I., Engelmann, C., Modest, D.P., Pelzer, U., Krenzien, F., Raschzok, N., and Benzing, C. (2022). Prognostic and Predictive Molecular Markers in Cholangiocarcinoma. Cancers, 14.","DOI":"10.3390\/cancers14041026"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/18\/2998\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:54:08Z","timestamp":1760129648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/18\/2998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":32,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["diagnostics13182998"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13182998","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]}}}