{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:43:57Z","timestamp":1788263037524,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Health Science and Technology Project","award":["TJWJ2021ZD010"],"award-info":[{"award-number":["TJWJ2021ZD010"]}]},{"name":"Tianjin Health Science and Technology Project","award":["TJWJ2021MS034"],"award-info":[{"award-number":["TJWJ2021MS034"]}]},{"name":"Tianjin Health Science and Technology Project","award":["2022KJ275"],"award-info":[{"award-number":["2022KJ275"]}]},{"name":"Tianjin Education Commission Research Project","award":["TJWJ2021ZD010"],"award-info":[{"award-number":["TJWJ2021ZD010"]}]},{"name":"Tianjin Education Commission Research Project","award":["TJWJ2021MS034"],"award-info":[{"award-number":["TJWJ2021MS034"]}]},{"name":"Tianjin Education Commission Research Project","award":["2022KJ275"],"award-info":[{"award-number":["2022KJ275"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Currently, most primary hospitals cannot routinely perform liver stiffness measurements (LSMs) and spleen stiffness measurements (SSMs), which are recommended by guidelines to exclude high-risk varices (HRVs). We tried to find more convenient indicators for HRV screening. We enrolled 213 cirrhosis patients as the training cohort (TC) and 65 primary biliary cirrhosis patients as the validation cohort (VC). We included indicators such as SSM by two-dimensional shear wave elastography, LSM by transient elastography, and other imaging and laboratory tests. Variable analysis revealed SSM, platelets (PLT), and spleen thickness (ST) as independent risk indicators for HRV. In TC, ST+PLT (ST &lt; 42.2 mm and PLT &gt; 113.5 \u00d7 109\/L) could avoid 35.7% of the esophagogastroduodenoscopies (EGDs), with a 2.4% missed HRV rate. Although the proportion of EGDs spared by ST+PLT was less than SSM+PLT (SSM &lt; 29.89 kPa + PLT &gt; 113.5 \u00d7 109\/L) (35.7% vs. 44.1%), it was higher than that of the Baveno VI criteria (B6) (35.7% vs. 28.2%). We did not validate SSM+PLT in VC considering our aims. ST+PLT safely spared 24.6% of EGDs in VC, identical to B6. Conclusions: The ability of ST+PLT to exclude HRVs was superior to B6 but slightly inferior to SSM+PLT. When SSM cannot be routinely performed, ST+PLT provides an extra option for patients to exclude HRVs as a more convenient model.<\/jats:p>","DOI":"10.3390\/diagnostics13203164","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:14:04Z","timestamp":1696918444000},"page":"3164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Spleen Thickness Plus Platelets Can Effectively and Safely Screen for High-Risk Varices in Cirrhosis Patients"],"prefix":"10.3390","volume":"13","author":[{"given":"Fengbin","family":"Zhang","sequence":"first","affiliation":[{"name":"Clinical School of the Second People\u2019s Hospital, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Gastroenterology and Hepatology, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghe","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical School of the Second People\u2019s Hospital, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Gastroenterology and Hepatology, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-417X","authenticated-orcid":false,"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Second People\u2019s Hospital, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2017.02.003","article-title":"Non-invasive evaluation of portal hypertension using ultrasound elastography","volume":"67","author":"Berzigotti","year":"2017","journal-title":"J. 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