{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:44:51Z","timestamp":1788493491173,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In patients with triple-negative breast cancer (TNBC)\u2014the subtype with the poorest prognosis among breast cancers\u2014it is crucial to assess the response to the currently widely employed neoadjuvant treatment (NAT) approaches. This study investigates the correlation between baseline conventional ultrasound (US) and shear-wave elastography (SWE) indicators and the pathological response of TNBC following NAT, with a specific focus on assessing predictive capability in the baseline state. This retrospective analysis was conducted by extracting baseline US features and SWE parameters, categorizing patients based on postoperative pathological grading. A univariate analysis was employed to determine the relationship between ultrasound indicators and pathological reactions. Additionally, we employed a receiver operating characteristic (ROC) curve analysis and multivariate logistic regression methods to evaluate the predictive potential of the baseline US indicators. This study comprised 106 TNBC patients, with 30 (28.30%) in a nonmajor histological response (NMHR) group and 76 (71.70%) in a major histological response (MHR) group. Following the univariate analysis, we found that T staging, dmax values, volumes, margin changes, skin alterations (i.e., thickening and invasion), retromammary space invasions, and supraclavicular lymph node abnormalities were significantly associated with pathological efficacy (p &lt; 0.05). Combining clinical information with either US or SWE independently yielded baseline predictive abilities, with AUCs of 0.816 and 0.734, respectively. Notably, the combined model demonstrated an improved AUC of 0.827, with an accuracy of 76.41%, a sensitivity of 90.47%, a specificity of 55.81%, and statistical significance (p &lt; 0.01). The baseline US and SWE indicators for TNBC exhibited a strong relationship with NAT response, offering predictive insights before treatment initiation, to a considerable extent.<\/jats:p>","DOI":"10.3390\/diagnostics13203178","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T08:07:12Z","timestamp":1697011632000},"page":"3178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlation between Baseline Conventional Ultrasounds, Shear-Wave Elastography Indicators, and Neoadjuvant Therapy Efficacy in Triple-Negative Breast Cancer"],"prefix":"10.3390","volume":"13","author":[{"given":"Siyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital, Sichuan University, Wai Nan Guo Xue Xiang 37, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital, Sichuan University, Wai Nan Guo Xue Xiang 37, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital, Sichuan University, Wai Nan Guo Xue Xiang 37, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital, Sichuan University, Wai Nan Guo Xue Xiang 37, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital, Sichuan University, Wai Nan Guo Xue Xiang 37, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-0746","authenticated-orcid":false,"given":"Yulan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, West China Hospital, Sichuan University, Wai Nan Guo Xue Xiang 37, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1309\/AJCPQN8GZ8SILKGN","article-title":"Triple-negative breast carcinoma: Current and emerging concepts","volume":"141","author":"Schmadeka","year":"2014","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.2147\/CMAR.S247279","article-title":"Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41571-021-00565-2","article-title":"Treatment landscape of triple-negative breast cancer\u2014Expanded options, evolving needs","volume":"19","author":"Bianchini","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_4","unstructured":"Professional Committee on Breast Cancer, China Anti-Cancer Association (2021). Guidelines and specifications for diagnosis and treatment of breast cancer of China Anti-Cancer Association (2021 Edition). China Oncol., 31, 954\u20131040. (In Chinese)."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0140-6736(13)62422-8","article-title":"Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis","volume":"384","author":"Cortazar","year":"2014","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/jcp.26103","article-title":"Neoadjuvant chemotherapy in triple-negative breast cancer: A multicentric retrospective observational study in real-life setting","volume":"233","author":"Gamucci","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/SLA.0000000000002953","article-title":"The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT): A Review of 20,000 Breast Cancer Patients in the National Cancer Data Base (NCDB)","volume":"268","author":"Fayanju","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.21037\/gs-21-320","article-title":"Application value of conventional ultrasound combined with shear wave elastography in diagnosing triple negative breast cancer","volume":"10","author":"Sheng","year":"2021","journal-title":"Gland Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.ultrasmedbio.2022.01.018","article-title":"Mid-treatment Ultrasound Descriptors as Qualitative Imaging Biomarkers of Pathologic Complete Response in Patients with Triple-Negative Breast Cancer","volume":"48","author":"Candelaria","year":"2022","journal-title":"Ultrasound Med. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.201102147","article-title":"The extracellular matrix: A dynamic niche in cancer progression","volume":"196","author":"Lu","year":"2012","journal-title":"J. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1158\/1078-0432.CCR-17-3262","article-title":"Tumor Elastography and Its Association with Collagen and the Tumor Microenvironment","volume":"24","author":"Riegler","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.diii.2013.01.022","article-title":"Ultrasound elastography: Principles and techniques","volume":"94","author":"Gennisson","year":"2013","journal-title":"Diagn. Interv. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.14366\/usg.17024","article-title":"Shear-wave elastography in breast ultrasonography: The state of the art","volume":"36","author":"Youk","year":"2017","journal-title":"Ultrasonography"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00330-011-2340-y","article-title":"Shear wave elastography for breast masses is highly reproducible","volume":"22","author":"Cosgrove","year":"2012","journal-title":"Eur. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.clbc.2015.01.002","article-title":"The Journey of Elastography: Background, Current Status, and Future Possibilities in Breast Cancer Diagnosis","volume":"15","author":"Faruk","year":"2015","journal-title":"Clin. Breast Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.7863\/ultra.15.08052","article-title":"Early Evaluation of Relative Changes in Tumor Stiffness by Shear Wave Elastography Predicts the Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer","volume":"35","author":"Jing","year":"2016","journal-title":"J. Ultrasound Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s12282-021-01327-9","article-title":"Usefulness of new shear wave elastography in early predicting the efficacy of neoadjuvant chemotherapy for patients with breast cancer: Where and when to measure is optimal?","volume":"29","author":"Gu","year":"2022","journal-title":"Breast Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.2147\/CMAR.S331665","article-title":"A Narrative Review of Ultrasound Technologies for the Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer","volume":"13","author":"Wang","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.breast.2021.12.019","article-title":"Neoadjuvant approach in patients with early breast cancer: Patient assessment, staging, and planning","volume":"62","author":"Rubio","year":"2022","journal-title":"Breast"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.5858\/134.7.e48","article-title":"American Society of Clinical Oncology\/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer","volume":"134","author":"Hammond","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3322\/caac.21388","article-title":"The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA A Cancer J. Clin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"310","DOI":"10.6004\/jnccn.2018.0012","article-title":"Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology","volume":"16","author":"Gradishar","year":"2018","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.rcl.2014.02.008","article-title":"BI-RADS update","volume":"52","author":"Mercado","year":"2014","journal-title":"Radiol. Clin. N. Am."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.ultrasmedbio.2015.03.008","article-title":"WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 2: Breast","volume":"41","author":"Barr","year":"2015","journal-title":"Ultrasound Med. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0960-9776(03)00106-1","article-title":"A new histological grading system to assess response of breast cancers to primary chemotherapy: Prognostic significance and survival","volume":"12","author":"Ogston","year":"2003","journal-title":"Breast"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00330-016-4565-2","article-title":"Investigating the prediction value of multiparametric magnetic resonance imaging at 3 T in response to neoadjuvant chemotherapy in breast cancer","volume":"27","author":"Minarikova","year":"2017","journal-title":"Eur. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.21037\/gs-20-836","article-title":"Prediction of treatment responses to neoadjuvant chemotherapy in breast cancer using contrast-enhanced ultrasound","volume":"10","author":"Huang","year":"2021","journal-title":"Gland Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1002\/cncr.33604","article-title":"Early ultrasound evaluation identifies excellent responders to neoadjuvant systemic therapy among patients with triple-negative breast cancer","volume":"127","author":"Adrada","year":"2021","journal-title":"Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.2214\/AJR.09.2355","article-title":"Multimodality imaging of triple receptor-negative tumors with mammography, ultrasound, and MRI","volume":"194","author":"Dogan","year":"2010","journal-title":"AJR. Am. J. Roentgenol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1055\/s-0043-111589","article-title":"Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Ultrasound, Shear Wave Elastography and MRI","volume":"39","author":"Evans","year":"2018","journal-title":"Ultraschall. Med."},{"key":"ref_31","first-page":"6","article-title":"Study on the Relationship between Multimodal Ultrasound Marginal Zone Signs and Prognostic Factors in Breast Cancer","volume":"51","author":"Ruyi","year":"2022","journal-title":"J. Med. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1148\/radiol.2016152331","article-title":"Pretreatment MR Imaging Features of Triple-Negative Breast Cancer: Association with Response to Neoadjuvant Chemotherapy and Recurrence-Free Survival","volume":"281","author":"Bae","year":"2016","journal-title":"Radiology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"879.e813","DOI":"10.1016\/j.crad.2020.07.012","article-title":"Associations between the ultrasound features of invasive breast cancer and breast cancer specific survival","volume":"75","author":"Lawson","year":"2020","journal-title":"Clin. Radiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10549-017-4324-3","article-title":"Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer","volume":"165","author":"Houssami","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s10549-011-1737-2","article-title":"Predicting lymphatic drainage patterns and primary tumour location in patients with breast cancer","volume":"130","author":"Blumgart","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jama.2013.278932","article-title":"Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: The ACOSOG Z1071 (Alliance) clinical trial","volume":"310","author":"Boughey","year":"2013","journal-title":"JAMA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/S0960-9776(21)00166-1","article-title":"Application of conventional ultrasonography combined with contrast-enhanced ultrasonography in the lymph nodes and evaluation of the efficacy of neoadjuvant chemotherapy in breast cancer patients","volume":"56","author":"Jin","year":"2021","journal-title":"Breast"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"845823","DOI":"10.3389\/fonc.2022.845823","article-title":"Accuracy of ultrasonographic changes during neoadjuvant chemotherapy to predict axillary lymph node response in clinical node-positive breast cancer patients","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_39","first-page":"6","article-title":"Risk factors of supraclavicular lymph node positive after neoadjuvant chemotherapy and prognostic analysis in breast cancer patients with synchronous ipsilateral supraclavicular lymph node metastasis","volume":"13","author":"Dandan","year":"2019","journal-title":"Chin. J. Breast Dis. (Electron. Ed.)"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1097\/CM9.0000000000001755","article-title":"Development and validation of a nomogram for predicting survival of breast cancer patients with ipsilateral supraclavicular lymph node metastasis","volume":"134","author":"Lyu","year":"2021","journal-title":"Chin. Med. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clbc.2013.09.008","article-title":"Outcomes of Patients with Breast Cancer Who Present with Ipsilateral Supraclavicular or Internal Mammary Lymph Node Metastases","volume":"14","author":"Dellapasqua","year":"2014","journal-title":"Clin. Breast Cancer"},{"key":"ref_42","first-page":"3526","article-title":"Clinical characteristics and prognostic analysis of ipsilateral supraclavicular lymph node metastases in breast cancer patients: A retrospective study","volume":"12","author":"Jin","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10549-022-06804-z","article-title":"Correlation analysis between shear-wave elastography and pathological profiles in breast cancer","volume":"197","author":"Li","year":"2023","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_44","first-page":"2798","article-title":"Can shear-wave elastography predict response to neoadjuvant chemotherapy in women with invasive breast cancer?","volume":"109","author":"Evans","year":"2013","journal-title":"Breast Dis. A Year Book Q."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.clinimag.2022.06.008","article-title":"Value of shear wave elasticity in predicting the efficacy of neoadjuvant chemotherapy in different molecular types","volume":"89","author":"Yuan","year":"2022","journal-title":"Clin. Imaging"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"910.e1","DOI":"10.1016\/j.crad.2018.05.030","article-title":"Identification of pathological complete response after neoadjuvant chemotherapy for breast cancer: Comparison of greyscale ultrasound, shear wave elastography, and MRI","volume":"73","author":"Evans","year":"2018","journal-title":"Clin. Radiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bioactmat.2022.10.025","article-title":"Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment","volume":"22","author":"Zheng","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"110609","DOI":"10.1016\/j.ejrad.2022.110609","article-title":"Comparison of diagnostic potential of shear wave elastography between breast mass lesions and non-mass-like lesions","volume":"158","author":"Li","year":"2023","journal-title":"Eur. J. Radiol."},{"key":"ref_49","first-page":"773","article-title":"The Ki-67 expression change after neoadjuvant chemotherapy in triple negative breast cancer and the correlation with efficacy and prognosis","volume":"29","author":"Shihao","year":"2021","journal-title":"Mod. Oncol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/20\/3178\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:05:02Z","timestamp":1760130302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/20\/3178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":49,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["diagnostics13203178"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13203178","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]}}}