{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:48:14Z","timestamp":1787878094010,"version":"build-2784847793"},"reference-count":32,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>This study aimed to investigate the relationship between quantitative and volumetric parameters of technetium-99-methoxyisobutylisonitrile (99mTc-MIBI) single-photon emission computed tomography\/computed tomography (SPECT\/CT) imaging and hormonal and biochemical markers in primary hyperparathyroidism (PHPT) patients with single adenoma. In this retrospective study, 70 patients with a single adenoma who underwent 99mTc-MIBI imaging for the diagnosis of PHPT were examined. Early and delayed MIBI lesion\/background ratios (eLBR and dLBR), early and delayed lesion\/thyroid ratio (eLTR and dLTR), and retention index (RI) were calculated as planar dual-phase scintigraphy parameters. Adenoma volume (Svol) and parathormone (PTH)\/Svol ratio were measured as SPECT\/CT-derived parameters. Calcium levels exhibited a positive correlation with eLBR (r = 0.33, p &lt; 0.001), dLBR (r = 0.29, p = 0.01), dLTR (r = 0.31, p &lt; 0.001), and PTH\/Svol (r = 0.38, p &lt; 0.001). PTH did not correlate with planar parameters and Svol. Among the imaging parameters, only the PTH\/Svol ratio showed a negative correlation with phosphorus levels (r = \u22120.29, p = 0.02). For predicting disease severity, the PTH\/Svol ratio exhibited similar diagnostic performance to PTH and phosphorus levels but outperformed the eLBR and dLBR. Both planar and SPECT-derived parameters can provide valuable insights into the functional status of the parathyroid adenoma and the associated disease severity. PTH\/Svol ratio, combining imaging and laboratory findings to provide a more comprehensive approach to patient care, could be an exciting new indicator.<\/jats:p>","DOI":"10.3390\/diagnostics13203182","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:07:47Z","timestamp":1697080067000},"page":"3182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Relationship between Planar and SPECT\/CT Parameters and Functional Markers in Primary Hyperparathyroidism"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-8634","authenticated-orcid":false,"given":"Guler","family":"Silov","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Samsun University Faculty of Medicine, Samsun 55200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil","family":"Erdogan Ozbodur","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Gazi State Hospital, Samsun Provincial Health Directorate, Samsun 55070, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0140-6736(17)31430-7","article-title":"Hyperparathyroidism","volume":"391","author":"Bilezikian","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1056\/NEJMcp1714213","article-title":"Primary Hyperparathyroidism","volume":"379","author":"Insogna","year":"2018","journal-title":"N. 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