{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:47:51Z","timestamp":1791395271752,"version":"4.3.3"},"reference-count":72,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca (MUR) FAR 2022"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Non-cirrhotic portal hypertension (NCPH), also known as idiopathic non-cirrhotic portal hypertension (INCPH) and porto-sinusoidal vascular disorder (PSVD), is a rare disease characterized by intrahepatic portal hypertension (IPH) in the absence of cirrhosis. The precise etiopathogenesis of IPH is an area of ongoing research. NCPH diagnosis is challenging, as there are no specific tests available to confirm the disease, and a high-quality liver biopsy, detailed clinical information, and an expert pathologist are necessary for diagnosis. Currently, the treatment of NCPH relies on the prevention of complications related to portal hypertension, following current guidelines of cirrhotic portal hypertension. No treatment has been studied that aimed to modify the natural history of the disease; however, transjugular intrahepatic porto-systemic shunt (TIPS) placement, shunt and liver transplantation are considerable symptomatic options. In this review, we discuss the heterogeneity of NCPH as well as its etiopathogenesis, clinical presentation and management issues. Starting from the assumption that portal hypertension does not always mean cirrhosis, cooperative studies are probably needed to clarify the issues of etiology and the possible genetic background of this rare disease. This knowledge might lead to better treatment and perhaps better prevention.<\/jats:p>","DOI":"10.3390\/diagnostics13203263","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T07:22:32Z","timestamp":1697786552000},"page":"3263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Narrative Review on Non-Cirrohotic Portal Hypertension: Not All Portal Hypertensions Mean Cirrhosis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5284-9220","authenticated-orcid":false,"given":"Michele","family":"Fiordaliso","sequence":"first","affiliation":[{"name":"Department of Medicine and Ageing Sciences, University \u201cG. D\u2019Annunzio\u201d of Chieti\u2013Pescara, Via dei Vestini 29, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Marincola","sequence":"additional","affiliation":[{"name":"Bariatric and Metabolic Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pala","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Via di Grottarossa, 1035\/1039, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Muraro","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d of Chieti\u2013Pescara, Via dei Vestini 29, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-1291","authenticated-orcid":false,"given":"Mariangela","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d of Chieti\u2013Pescara, Via dei Vestini 29, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-9857","authenticated-orcid":false,"given":"Maria Carmela","family":"Di Marcantonio","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d of Chieti\u2013Pescara, Via dei Vestini 29, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Mincione","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d of Chieti\u2013Pescara, Via dei Vestini 29, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/hep.24422","article-title":"Idiopathic noncirrhotic portal hypertension","volume":"54","author":"Schouten","year":"2011","journal-title":"Hepatology"},{"key":"ref_2","first-page":"21","article-title":"Splenomegalie mit Leberzirrhose Beitrage zur Pathologischen","volume":"24","author":"Banti","year":"1889","journal-title":"Anat. Allg. Pathol."},{"key":"ref_3","first-page":"259","article-title":"Non-cirrhotic intrahepatic portal hypertension: A long term follow-up study","volume":"50","author":"Kingham","year":"1981","journal-title":"QJM Int. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/00000658-196510000-00006","article-title":"Extra- and intrahepatic portal hypertension without cirrhosis (hepatoportal sclerosis)","volume":"162","author":"Mikkelsen","year":"1965","journal-title":"Ann. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/gut.51.2.275","article-title":"Idiopathic non-cirrhotic portal hypertension in the West: A re-evaluation in 28 patients","volume":"51","author":"Hillaire","year":"2002","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12664-009-0030-3","article-title":"Idiopathic non-cirrhotic intrahepatic portal hypertension: Common cause of cryptogenic intrahepatic portal hypertension in a Southern Indian tertiary hospital","volume":"28","author":"Madhu","year":"2009","journal-title":"Indian J. Gastroenterol."},{"key":"ref_7","unstructured":"Kobayashi, Y., Inokuchi, K., Saku, M., and Yo, S. (1975). Epidemiology and clinical features of idiopathic portal hypertension, 1975 Report of the Ministry of Health and Welfare Research Committee on Idiopathic Portal Hypertension."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s12072-007-9010-9","article-title":"Noncirrhotic portal fibrosis\/idiopathic portal hypertension: APASL recommendations for diagnosis and treatment","volume":"1","author":"Sarin","year":"2007","journal-title":"Hepatol. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-2002-23207","article-title":"Idiopathic portal hypertension and its pathology","volume":"22","author":"Okudaira","year":"2002","journal-title":"Semin. Liver Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.7326\/0003-4819-71-3-660","article-title":"Obliterative portal venopathy of the liver and \u201cidiopathic portal hypertension\u201d","volume":"71","author":"Iber","year":"1969","journal-title":"Ann. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/hep.1840110512","article-title":"Micronodular transformation (nodular regenerative hyperplasia) of the liver: A report of 64 cases among 2500 autopsies and a new classification of benign hepatocellular nodules","volume":"11","author":"Wanless","year":"1990","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/j.1365-2036.2012.05112.x","article-title":"Idiopathic noncirrhotic portal hypertension is associated with poor survival: Results of a long-term cohort study","volume":"35","author":"Schouten","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1002\/hep.26904","article-title":"Idiopathic portal hypertension: Natural history and long-term outcome","volume":"59","author":"Siramolpiwat","year":"2014","journal-title":"Hepatology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/liv.12974","article-title":"Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies","volume":"36","author":"Barge","year":"2016","journal-title":"Liver Int."},{"key":"ref_15","first-page":"409","article-title":"Differences in portal hemodynamics in cirrhosis and idiopathic portal hypertension","volume":"84","author":"Ohnishi","year":"1989","journal-title":"Am. J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/his.13738","article-title":"International Liver Pathology Study Group. Histology of portal vascular changes associated with idiopathic non-cirrhotic portal hypertension: Nomenclature and definition","volume":"74","author":"Guido","year":"2019","journal-title":"Histopathology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2214\/ajr.134.5.917","article-title":"Portographic liver changes in idiopathic noncirrhotic portal hypertension","volume":"134","author":"Futagawa","year":"1980","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/PAP.0000000000000312","article-title":"Regression of Hepatic Fibrosis and Evolution of Cirrhosis: A Concise Review","volume":"28","author":"Khan","year":"2021","journal-title":"Adv. Anat. Pathol."},{"key":"ref_19","first-page":"1732069","article-title":"Progression of Hepatic Adenoma to Carcinoma in the Setting of Hepatoportal Sclerosis in HIV Patient: Case Report and Review of the Literature","volume":"2016","author":"Montenovo","year":"2016","journal-title":"Case Rep. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1078\/0344-0338-5710012","article-title":"Pathology and pathogenesis of idiopathic portal hypertension with an emphasis on the liver","volume":"197","author":"Nakanuma","year":"2001","journal-title":"Pathol. Res. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S2468-1253(19)30047-0","article-title":"Porto-sinusoidal vascular disease: Proposal and description of a novel entity","volume":"4","author":"Rautou","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00004836-200210000-00012","article-title":"Connective tissue diseases and the liver","volume":"35","author":"Youssef","year":"2002","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.mpg.0000180029.73272.45","article-title":"Nodular regenerative hyperplasia associated with idiopathic thrombocytopenic purpura in a young girl: A case report and review of the literature","volume":"41","author":"Mahamid","year":"2005","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajh.20024","article-title":"Nodular regenerative hyperplasia of the liver: An under-recognized cause of portal hypertension in hematological disorders","volume":"75","author":"Rosenberg","year":"2004","journal-title":"Am. J. Hematol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/hep.21258","article-title":"Nodular regenerative hyperplasia: Not all nodules are created equal","volume":"44","author":"Reshamwala","year":"2006","journal-title":"Hepatology"},{"key":"ref_26","first-page":"838","article-title":"Nodular regenerative hyperplasia of the liver in a patient with rheumatoid vasculitis: A morphometric study suggesting a role for hepatic arteritis in the pathogenesis","volume":"11","author":"Reynolds","year":"1984","journal-title":"J. Rheumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.humpath.2004.06.016","article-title":"Intrasinusoidal cytotoxic CD8+ T cells in nodular regenerative hyperplasia of the liver","volume":"35","author":"Ziol","year":"2004","journal-title":"Hum. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/ajg.2009.165","article-title":"Idiopathic portal hypertension in patients with HIV infection treated with highly active antiretroviral therapy","volume":"104","author":"Chang","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/apt.12049","article-title":"Risk factors and outcome of HIV-associated idiopathic noncirrhotic portal hypertension","volume":"36","author":"Schouten","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"346","DOI":"10.9734\/BJMMR\/2011\/554","article-title":"Didanosine Exposure and Noncirrhotic Portal Hypertension in a HIV Clinic in North America: A Follow-up Study","volume":"1","author":"Cachay","year":"2011","journal-title":"Br. J. Med. Med. Res."},{"key":"ref_31","first-page":"163","article-title":"Non-specific immunological abnormalities and association of autoimmune diseases in idiopathic portal hypertension. A study by questionnaire","volume":"40","author":"Saito","year":"1993","journal-title":"Hepatogastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s005350050336","article-title":"Idiopathic portal hypertension associated with systemic lupus erythematosus","volume":"35","author":"Inagaki","year":"2000","journal-title":"J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1046\/j.1440-1746.2002.02587.x","article-title":"Overlap of idiopathic portal hypertension and scleroderma: Report of two autopsy cases and a review of literature","volume":"17","author":"Tsuneyama","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.hepres.2004.06.001","article-title":"A case of merged idiopathic portal hypertension in course of mixed connective tissue disease","volume":"30","author":"Rai","year":"2004","journal-title":"Hepatol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/s10165-006-0479-1","article-title":"A case of systemic sclerosis complicated by idiopathic portal hypertension: Case report and literature review","volume":"16","author":"Takagi","year":"2006","journal-title":"Mod. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10620-010-1278-2","article-title":"Non-cirrhotic intrahepatic portal hypertension: Associated gut diseases and prognostic factors","volume":"56","author":"Eapen","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1046\/j.1440-1746.1999.01857.x","article-title":"Analysis of adhesion molecules in patients with idiopathic portal hypertension","volume":"14","author":"Yamaguchi","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1007\/s10620-006-9596-0","article-title":"Clinical features, serum interleukin-6, and interferon-gamma levels of 34 turkish patients with hepatoportal sclerosis","volume":"52","author":"Balci","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"ref_39","first-page":"174","article-title":"Portal vein thrombosis leading to pre-sinusoidal non-cirrhotic portal hypertension resulting in decreased synthetic function of the liver","volume":"12","author":"Kline","year":"2019","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000007502","article-title":"Idiopathic portal hypertension","volume":"59","author":"Sarin","year":"1998","journal-title":"Digestion"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0016-5085(88)90255-7","article-title":"Experimental portal fibrosis produced by intraportal injection of killed nonpathogenic Escherichia coli in rabbits","volume":"94","author":"Kono","year":"1988","journal-title":"Gastroenterology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1136\/gut.2003.036806","article-title":"Nodular regenerative hyperplasia of the liver and coeliac disease: Potential role of IgA anticardiolipin antibody","volume":"53","author":"Austin","year":"2004","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1111\/j.1572-0241.2007.01428.x","article-title":"Hepatoportal sclerosis as a cause of noncirrhotic portal hypertension in patients with HIV","volume":"102","author":"Schiano","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5217\/ir.2020.00016","article-title":"Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn\u2019s disease","volume":"19","author":"Seo","year":"2021","journal-title":"Intest. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.14740\/jmc3630","article-title":"Non-Cirrhotic Portal Hypertension in a Patient with Colonic Carcinoma Treated with Oxaliplatin","volume":"12","author":"Gomez","year":"2021","journal-title":"J. Med. Cases"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/hep.28499","article-title":"Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension","volume":"63","author":"Vilarinho","year":"2016","journal-title":"Hepatology"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Calado, R.T., Regal, J.A., Kleiner, D.E., Schrump, D.S., Peterson, N.R., Pons, V., Chanock, S.J., Lansdorp, P.M., and Young, N.S. (2009). A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007926"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1046\/j.1440-1746.2002.02764.x","article-title":"Non-cirrhotic portal fibrosis: Current concepts and management","volume":"17","author":"Sarin","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13023-015-0288-8","article-title":"Idiopathic non-cirrhotic portal hypertension: A review","volume":"10","author":"Schouten","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.dld.2018.01.132","article-title":"Natural history of patients with non cirrhotic portal hypertension: Comparison with patients with compensated cirrhosis","volume":"50","author":"Gioia","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.dld.2016.06.014","article-title":"Hepatic encephalopathy in patients with non-cirrhotic portal hypertension: Description, prevalence and risk factors","volume":"48","author":"Nicoletti","year":"2016","journal-title":"Dig. Liver Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hep.28547","article-title":"Role of the transjugular intrahepatic portosystemic shunt in the management of severe complications of portal hypertension in idiopathic noncirrhotic portal hypertension","volume":"64","author":"Bissonnette","year":"2016","journal-title":"Hepatology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1259\/bjr\/25522379","article-title":"Non-invasive portography: A microbubble-induced three-dimensional sonogram for discriminating idiopathic portal hypertension from cirrhosis","volume":"85","author":"Maruyama","year":"2012","journal-title":"Br. J. Radiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.3748\/wjg.v11.i43.6858","article-title":"Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome","volume":"11","author":"Drake","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1046\/j.1440-1746.2002.02596.x","article-title":"Non-cirrhotic portal fibrosis (idiopathic portal hypertension): Experience with 151 patients and a review of the literature","volume":"17","author":"Dhiman","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1053\/j.gastro.2008.01.034","article-title":"Performance of transient elastography for the staging of liver fibrosis: A meta-analysis","volume":"134","author":"Ong","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.31688","article-title":"Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease with portal hypertension","volume":"74","author":"Elkrief","year":"2021","journal-title":"Hepatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.dld.2022.09.018","article-title":"Splenic-hepatic elastography index is useful in differentiating between porto-sinusoidal vascular disease and cirrhosis in patients with portal hypertension","volume":"55","author":"Gaspar","year":"2023","journal-title":"Dig. Liver Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1080\/00365521.2021.1968485","article-title":"Transient splenic elastography predicts high-risk esophageal varices in patients with non-cirrhotic portal hypertension","volume":"56","author":"Gaspar","year":"2021","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1111\/liv.14997","article-title":"Autoimmune biomarkers in porto-sinusoidal vascular disease: Potential role in its diagnosis and pathophysiology","volume":"41","author":"Magaz","year":"2021","journal-title":"Liver Int."},{"key":"ref_61","first-page":"179","article-title":"Use of serum vitamin B12 level as a marker to differentiate idiopathic noncirrhotic intrahepatic portal hypertension from cryptogenic cirrhosis","volume":"58","author":"Goel","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S1613","DOI":"10.14309\/01.ajg.0000601412.42554.33","article-title":"Non-Cirrhotic Portal Hypertension in Myeloproliferative Disease: Left and Right-Sided Component of Portal Hypertension: 2970","volume":"114","author":"Sharma","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/hep.28466","article-title":"Natural history and management of esophagogastric varices in chronic noncirrhotic, nontumoral portal vein thrombosis","volume":"63","author":"Seijo","year":"2016","journal-title":"Hepatology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/hep.1840200114","article-title":"Nodular regenerative hyperplasia of the liver graft after liver transplantation","volume":"20","author":"Gane","year":"1994","journal-title":"Hepatology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/apt.15186","article-title":"TIPSS for variceal bleeding in patients with idiopathic non-cirrhotic portal hypertension: Comparison with patients who have cirrhosis","volume":"49","author":"Lv","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0720-048X(03)00134-7","article-title":"Partial splenic embolization in patients with idiopathic portal hypertension","volume":"49","author":"Romano","year":"2004","journal-title":"Eur. J. Radiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9623","DOI":"10.3748\/wjg.v22.i43.9623","article-title":"Outcomes of partial splenic embolization in patients with massive splenomegaly due to idiopathic portal hypertension","volume":"22","author":"Ozturk","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.12659\/AOT.898253","article-title":"Portosystemic shunt surgery in patients with idiopathic noncirrhotic portal hypertension","volume":"21","author":"Karagul","year":"2016","journal-title":"Ann. Transplant."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jamcollsurg.2011.12.042","article-title":"Prosthetic H-graft portacaval shunts vs transjugular intrahepatic portasystemic stent shunts: 18-year follow-up of a randomized trial","volume":"214","author":"Rosemurgy","year":"2012","journal-title":"J. Am. Coll. Surg."},{"key":"ref_70","first-page":"107","article-title":"Operations for management of esophageal variceal hemorrhage","volume":"136","author":"Rikkers","year":"1982","journal-title":"West. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0002-9610(88)80411-2","article-title":"Selective distal splenorenal shunt versus side-to-side portacaval shunt. Clinical results of a prospective, controlled study","volume":"155","author":"Spina","year":"1988","journal-title":"Am. J. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2169\/internalmedicine.46.1768","article-title":"Transjugular intrahepatic portosystemic shunt for the treatment of portal hypertension due to idiopathic myelofibrosis","volume":"46","author":"Doki","year":"2007","journal-title":"Intern. Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/20\/3263\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:10:17Z","timestamp":1760130617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/20\/3263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":72,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["diagnostics13203263"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13203263","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,20]]}}}