{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:52:01Z","timestamp":1789656721632,"version":"4.0.1"},"reference-count":60,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Lung cancer is the leading cause of cancer deaths in men and women in the United States. Accurate staging is needed to determine prognosis and devise effective treatment plans. The International Association for the Study of Lung Cancer (IASLC) has made multiple revisions to the tumor, node, metastasis (TNM) staging system used by the Union for International Cancer Control and the American Joint Committee on Cancer to stage lung cancer. The eighth edition of this staging system includes modifications to the T classification with cut points of 1 cm increments in tumor size, grouping of lung cancers associated with partial or complete lung atelectasis or pneumonitis, grouping of tumors with involvement of a main bronchus regardless of distance from the carina, and upstaging of diaphragmatic invasion to T4. The N classification describes the spread to regional lymph nodes and no changes were proposed for TNM-8. In the M classification, metastatic disease is divided into intra- versus extrathoracic metastasis, and single versus multiple metastases. In order to optimize patient outcomes, it is important to understand the nuances of the TNM staging system, the strengths and weaknesses of various imaging modalities used in lung cancer staging, and potential pitfalls in image interpretation.<\/jats:p>","DOI":"10.3390\/diagnostics13213359","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:24:04Z","timestamp":1698823444000},"page":"3359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Lung Cancer Staging: Imaging and Potential Pitfalls"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7908-5572","authenticated-orcid":false,"given":"Lauren T.","family":"Erasmus","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Faculty of Sciences, McGill University, Montreal, QC H3A 0G4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor A.","family":"Strange","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad D.","family":"Strange","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4446-9399","authenticated-orcid":false,"given":"Jitesh","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish S.","family":"Shroff","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-529X","authenticated-orcid":false,"given":"Mylene T.","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"ref_1","unstructured":"(2023, September 20). NCCN Clinical Practice Guidelines in Oncology, Non-Small Cell Lung Cancer, Version 4. Available online: https:\/\/www.nccn.org\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(21)00312-3","article-title":"Lung cancer","volume":"398","author":"Thai","year":"2021","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1148\/rg.2018170081","article-title":"Revisions to the TNM Staging of Lung Cancer: Rationale, Significance, and Clinical Application","volume":"38","author":"Carter","year":"2018","journal-title":"Radiographics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jtho.2015.10.008","article-title":"The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revision of the Clinical and Pathologic Staging of Small Cell Lung Cancer in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer","volume":"11","author":"Nicholson","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.rcl.2021.05.006","article-title":"PET Imaging of Neuroendocrine Tumors","volume":"59","author":"Galgano","year":"2021","journal-title":"Radiol. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jtho.2018.10.166","article-title":"Evaluation of the Prognostic Significance of TNM Staging Guidelines in Lung Carcinoid Tumors","volume":"14","author":"Yoon","year":"2019","journal-title":"J. Thorac. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.path.2019.10.003","article-title":"Lung Cancer Staging","volume":"13","author":"Kutob","year":"2020","journal-title":"Surg. Pathol. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jtho.2016.03.025","article-title":"The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer","volume":"11","author":"Travis","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1111\/1759-7714.13701","article-title":"Clinical T category for lung cancer staging: A pragmatic approach for real-world practice","volume":"11","author":"Choi","year":"2020","journal-title":"Thorac. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.acra.2020.04.007","article-title":"Clinical Non-Small Cell Lung Cancer Staging and Tumor Length Measurement Results From U.S. Cancer Hospitals","volume":"28","author":"Wu","year":"2021","journal-title":"Acad. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.21037\/tcr-22-2327","article-title":"CT-based three-dimensional invasiveness analysis of adenocarcinoma presenting as pure ground-glass nodules","volume":"12","author":"Oh","year":"2023","journal-title":"Transl. Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2214\/AJR.12.10033","article-title":"Comparison of multiplanar reformatted CT lung tumor measurements to axial tumor measurement alone: Impact on maximal tumor dimension and T stage","volume":"201","author":"Ridge","year":"2013","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejrad.2017.11.015","article-title":"Effect of computed tomography window settings and reconstruction plane on 8th edition T-stage classification in patients with lung adenocarcinoma manifesting as a subsolid nodule","volume":"98","author":"Ahn","year":"2018","journal-title":"Eur. J. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/JTO.0000000000000559","article-title":"The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer","volume":"10","author":"Bolejack","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mallum, A., Mkhize, T., Akudugu, J.M., Ngwa, W., and Vorster, M. (2022). The Role of Positron Emission Tomography and Computed Tomographic (PET\/CT) Imaging for Radiation Therapy Planning: A Literature Review. Diagnostics, 13.","DOI":"10.3390\/diagnostics13010053"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.hlc.2021.10.011","article-title":"Accuracy of (18)F-FDG in Detecting Stage I Lung Adenocarcinomas According to IASLC\/ATS\/ERS Classification","volume":"31","author":"Lococo","year":"2022","journal-title":"Heart Lung Circ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.5761\/atcs.oa.13-00005","article-title":"Invasiveness and malignant potential of pulmonary lesions presenting as pure ground-glass opacities","volume":"20","author":"Ichinose","year":"2014","journal-title":"Ann. Thorac. Cardiovasc. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2214\/AJR.19.21585","article-title":"Role of PET\/CT in Management of Early Lung Adenocarcinoma","volume":"214","author":"Shao","year":"2020","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1053\/j.semnuclmed.2021.06.008","article-title":"Limitations and Pitfalls of FDG-PET\/CT in Infection and Inflammation","volume":"51","author":"Pijl","year":"2021","journal-title":"Semin. Nucl. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jtho.2022.12.009","article-title":"The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Overview of Challenges and Opportunities in Revising the Nodal Classification of Lung Cancer","volume":"18","author":"Osarogiagbon","year":"2023","journal-title":"J. Thorac. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1200\/JCO.21.02528","article-title":"Management of Stage III Non-Small-Cell Lung Cancer: ASCO Guideline","volume":"40","author":"Daly","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/ejcts\/ezz147","article-title":"Comparison between lymph node station- and zone-based classification for the future revision of node descriptors proposed by the International Association for the Study of Lung Cancer in surgically resected patients with non-small-cell lung cancer","volume":"56","author":"Yun","year":"2019","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/icvts\/ivaa107","article-title":"Number of metastatic lymph nodes and zones as prognostic factors in non-small-cell lung cancer","volume":"31","author":"Maniwa","year":"2020","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ohno, Y., Ozawa, Y., Koyama, H., Yoshikawa, T., Takenaka, D., Nagata, H., Ueda, T., Ikeda, H., and Toyama, H. (2023). State of the Art MR Imaging for Lung Cancer TNM Stage Evaluation. Cancers, 15.","DOI":"10.3390\/cancers15030950"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1007\/s00259-023-06145-z","article-title":"A machine learning tool to improve prediction of mediastinal lymph node metastases in non-small cell lung cancer using routinely obtainable [(18)F]FDG-PET\/CT parameters","volume":"50","author":"Rogasch","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0003-4975(96)00220-2","article-title":"Distribution of distant metastases from newly diagnosed non-small cell lung cancer","volume":"62","author":"Quint","year":"1996","journal-title":"Ann. Thorac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/JTO.0000000000000673","article-title":"The IASLC Lung Cancer Staging Project: Proposals for the Revision of the M Descriptors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer","volume":"10","author":"Eberhardt","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1148\/rg.2018180060","article-title":"Role of FDG PET\/CT in the Eighth Edition of TNM Staging of Non-Small Cell Lung Cancer","volume":"38","author":"Kandathil","year":"2018","journal-title":"Radiographics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e211S","DOI":"10.1378\/chest.12-2355","article-title":"Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Silvestri","year":"2013","journal-title":"Chest"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E37","DOI":"10.1002\/ijc.27779","article-title":"Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography\/computed tomography for the detection of metastases in non-small-cell lung cancer patients","volume":"132","author":"Wu","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_32","first-page":"22","article-title":"The importance of 18F-FDG PET\/CT, CT and X-rays in detecting primary stage III A lung cancer and the incidence of extra thoracic metastases","volume":"12","author":"Sharma","year":"2009","journal-title":"Hell. J. Nucl. Med."},{"key":"ref_33","first-page":"32","article-title":"18F-FDG PET\/CT in the evaluation of adrenal masses","volume":"47","author":"Metser","year":"2006","journal-title":"J. Nucl. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1148\/radiol.2383042164","article-title":"Adrenal lesions: Characterization with fused PET\/CT image in patients with proved or suspected malignancy\u2014Initial experience","volume":"238","author":"Blake","year":"2006","journal-title":"Radiology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1148\/radiol.11100569","article-title":"Characterization of adrenal masses by using FDG PET: A systematic review and meta-analysis of diagnostic test performance","volume":"259","author":"Boland","year":"2011","journal-title":"Radiology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ejrad.2011.01.126","article-title":"A meta-analysis of (1)(8)FDG-PET-CT, (1)(8)FDG-PET, MRI and bone scintigraphy for diagnosis of bone metastases in patients with lung cancer","volume":"81","author":"Qu","year":"2012","journal-title":"Eur. J. Radiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/atm.ATM_276_16","article-title":"Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study","volume":"12","author":"Milovanovic","year":"2017","journal-title":"Ann. Thorac. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jbspin.2018.03.005","article-title":"Bone metastases from lung cancer: A paradigm for multidisciplinary onco-rheumatology management","volume":"86","author":"Confavreux","year":"2019","journal-title":"Jt. Bone Spine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3892\/mco.2023.2629","article-title":"Whole-body MRI for metastatic workup in patients diagnosed with cancer","volume":"18","author":"Rashid","year":"2023","journal-title":"Mol. Clin. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta23660","article-title":"Whole-body MRI compared with standard pathways for staging metastatic disease in lung and colorectal cancer: The Streamline diagnostic accuracy studies","volume":"23","author":"Taylor","year":"2019","journal-title":"Health Technol. Assess."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/1754-9485.12732","article-title":"Non-small cell lung cancer brain metastasis screening in the era of positron emission tomography-CT staging: Current practice and outcomes","volume":"62","author":"Diaz","year":"2018","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.lungcan.2013.02.006","article-title":"Screening for brain metastases in patients with stage III non-small cell lung cancer: Is there additive value of magnetic resonance imaging above a contrast-enhanced computed tomography of the brain?","volume":"80","author":"Hendriks","year":"2013","journal-title":"Lung Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0169-5002(03)00291-5","article-title":"MR-imaging of the brain of neurologic asymptomatic patients with large cell or adenocarcinoma of the lung. Does it influence prognosis and treatment?","volume":"42","author":"Hochstenbag","year":"2003","journal-title":"Lung Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41572-021-00261-6","article-title":"Liver metastases","volume":"7","author":"Tsilimigras","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"iv192","DOI":"10.1093\/annonc\/mdy275","article-title":"Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Planchard","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.1200\/JCO.2005.10.116","article-title":"Etiology of solitary extrapulmonary positron emission tomography and computed tomography findings in patients with lung cancer","volume":"23","author":"Lardinois","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1148\/radiol.211424","article-title":"Comparison of (68)Ga-FAPI and (18)F-FDG PET\/CT in the Evaluation of Advanced Lung Cancer","volume":"303","author":"Wang","year":"2022","journal-title":"Radiology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.thorsurg.2021.04.003","article-title":"Extended Pulmonary Resection by Sleeve Lobectomy and Carinal Pneumonectomy: Selection and Technique","volume":"31","author":"Costantino","year":"2021","journal-title":"Thorac. Surg. Clin."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.21037\/tlcr.2019.09.04","article-title":"PACIFIC: Shifting tides in the treatment of locally advanced non-small cell lung cancer","volume":"8","author":"Bang","year":"2019","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.athoracsur.2019.05.079","article-title":"Pulmonary Artery Resection During Lung Resection for Malignancy","volume":"108","author":"Madariaga","year":"2019","journal-title":"Ann. Thorac. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa0900043","article-title":"Preoperative staging of lung cancer with combined PET-CT","volume":"361","author":"Fischer","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7326\/0003-4819-151-4-200908180-00132","article-title":"Positron emission tomography in staging early lung cancer: A randomized trial","volume":"151","author":"Maziak","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2214\/AJR.18.19881","article-title":"Neuroendocrine Tumor Diagnosis and Management: (68)Ga-DOTATATE PET\/CT","volume":"211","author":"Sanli","year":"2018","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1053\/j.semnuclmed.2022.04.004","article-title":"[(18)F]FDG-PET\/CT Radiomics and Artificial Intelligence in Lung Cancer: Technical Aspects and Potential Clinical Applications","volume":"52","author":"Askari","year":"2022","journal-title":"Semin. Nucl. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ymeth.2020.11.002","article-title":"Can alternative PET reconstruction schemes improve the prognostic value of radiomic features in non-small cell lung cancer?","volume":"188","author":"Tankyevych","year":"2021","journal-title":"Methods"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s00259-019-04625-9","article-title":"Radiomics of (18)F-FDG PET\/CT images predicts clinical benefit of advanced NSCLC patients to checkpoint blockade immunotherapy","volume":"47","author":"Mu","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e190063","DOI":"10.1148\/ryai.2019190063","article-title":"Radiomics of (18)F Fluorodeoxyglucose PET\/CT Images Predicts Severe Immune-related Adverse Events in Patients with NSCLC","volume":"2","author":"Mu","year":"2020","journal-title":"Radiol. Artif. Intell."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"814","DOI":"10.2967\/jnumed.119.228106","article-title":"Pretreatment (18)F-FDG PET\/CT Radiomics Predict Local Recurrence in Patients Treated with Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer: A Multicentric Study","volume":"61","author":"Dissaux","year":"2020","journal-title":"J. Nucl. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/j.semnuclmed.2020.09.002","article-title":"Radiomics in PET\/CT: Current Status and Future AI-Based Evolutions","volume":"51","author":"Hatt","year":"2021","journal-title":"Semin. Nucl. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"17511","DOI":"10.1038\/s41598-022-21637-y","article-title":"Prediction of malignant lymph nodes in NSCLC by machine-learning classifiers using EBUS-TBNA and PET\/CT","volume":"12","author":"Guberina","year":"2022","journal-title":"Sci. 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