{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:28:08Z","timestamp":1790724488602,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["MOST 111-2628-B-038-025"],"award-info":[{"award-number":["MOST 111-2628-B-038-025"]}]},{"name":"National Science and Technology Council, Taiwan","award":["NSTC 112-2314-B-110-001"],"award-info":[{"award-number":["NSTC 112-2314-B-110-001"]}]},{"name":"National Science and Technology Council, Taiwan","award":["111-5812-001-400"],"award-info":[{"award-number":["111-5812-001-400"]}]},{"name":"National Science and Technology Council, Taiwan","award":["4152Z4-E03-01"],"award-info":[{"award-number":["4152Z4-E03-01"]}]},{"name":"National Science and Technology Council, Taiwan","award":["PD-049\/SP3\/LPPM-UAD\/VIII\/2023"],"award-info":[{"award-number":["PD-049\/SP3\/LPPM-UAD\/VIII\/2023"]}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["MOST 111-2628-B-038-025"],"award-info":[{"award-number":["MOST 111-2628-B-038-025"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-110-001"],"award-info":[{"award-number":["NSTC 112-2314-B-110-001"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["111-5812-001-400"],"award-info":[{"award-number":["111-5812-001-400"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["4152Z4-E03-01"],"award-info":[{"award-number":["4152Z4-E03-01"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["PD-049\/SP3\/LPPM-UAD\/VIII\/2023"],"award-info":[{"award-number":["PD-049\/SP3\/LPPM-UAD\/VIII\/2023"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Ahmad Dahlan, Indonesia","award":["MOST 111-2628-B-038-025"],"award-info":[{"award-number":["MOST 111-2628-B-038-025"]}]},{"name":"University of Ahmad Dahlan, Indonesia","award":["NSTC 112-2314-B-110-001"],"award-info":[{"award-number":["NSTC 112-2314-B-110-001"]}]},{"name":"University of Ahmad Dahlan, Indonesia","award":["111-5812-001-400"],"award-info":[{"award-number":["111-5812-001-400"]}]},{"name":"University of Ahmad Dahlan, Indonesia","award":["4152Z4-E03-01"],"award-info":[{"award-number":["4152Z4-E03-01"]}]},{"name":"University of Ahmad Dahlan, Indonesia","award":["PD-049\/SP3\/LPPM-UAD\/VIII\/2023"],"award-info":[{"award-number":["PD-049\/SP3\/LPPM-UAD\/VIII\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Dengue is an arboviral disease that has spread globally and become a major public health concern. A small proportion of patients may progress from symptomatic dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Findings from a previous genome-wide association study (GWAS) demonstrated that variations in the major histocompatibility complex (MHC) class I chain-related B (MICB) and the phospholipase C epsilon 1 (PLCE1) genes were related to DSS in a Vietnamese population. This study investigated associations of variations in MICB (rs3132468) and PLCE1 (rs3740360, rs3765524) with dengue severity and thrombocytopenia in both the Indonesian and Taiwanese populations. We sampled 160 patients from the Indonesian population and 273 patients from the Taiwanese population. None of the patients had DSS in the Taiwanese population. Based on age demographics, we found that dengue is more prevalent among younger individuals in the Indonesian population, whereas it has a greater impact on adults in the Taiwanese population. Our results showed the association between MICB rs3132468 and DSS. In addition, an association was identified between PLCE1 rs3740360 and DHF in secondary dengue in Indonesian patients. However, there is no association of MICB or PLCE1 variants with thrombocytopenia. This study highlights the value of genetic testing, which might be included in the clinical pathway for specific patients who can be protected from severe dengue.<\/jats:p>","DOI":"10.3390\/diagnostics13213365","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T11:51:43Z","timestamp":1698839503000},"page":"3365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic Association Studies of MICB and PLCE1 with Severity of Dengue in Indonesian and Taiwanese Populations"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-5591","authenticated-orcid":false,"given":"Imaniar Noor","family":"Faridah","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Ahmad Dahlan, Yogyakarta 55164, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haafizah","family":"Dania","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Ahmad Dahlan, Yogyakarta 55164, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Maliza","sequence":"additional","affiliation":[{"name":"Biology Department, Faculty of Mathematics and Natural Sciences, Andalas University, Padang 25175, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7693-5959","authenticated-orcid":false,"given":"Wan-Hsuan","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4494-1123","authenticated-orcid":false,"given":"Wen-Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung 80424, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-4844","authenticated-orcid":false,"given":"Yen-Hsu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung 80424, Taiwan"},{"name":"Division of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2638-6664","authenticated-orcid":false,"given":"Dyah Aryani","family":"Perwitasari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Ahmad Dahlan, Yogyakarta 55164, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chiao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan"},{"name":"Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"ref_1","unstructured":"(2023, February 20). 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