{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:19:14Z","timestamp":1782256754598,"version":"3.54.5"},"reference-count":25,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Government of India, Science and Engineering Research Board (SERB), Promoting Opportunities for Women in Exploratory Research (POWER)","doi-asserted-by":"publisher","award":["SPG\/2020\/000426"],"award-info":[{"award-number":["SPG\/2020\/000426"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The microscopic diagnostic differentiation of odontogenic cysts from other cysts is intricate and may cause perplexity for both clinicians and pathologists. Of particular interest is the odontogenic keratocyst (OKC), a developmental cyst with unique histopathological and clinical characteristics. Nevertheless, what distinguishes this cyst is its aggressive nature and high tendency for recurrence. Clinicians encounter challenges in dealing with this frequently encountered jaw lesion, as there is no consensus on surgical treatment. Therefore, the accurate and early diagnosis of such cysts will benefit clinicians in terms of treatment management and spare subjects from the mental agony of suffering from aggressive OKCs, which impact their quality of life. The objective of this research is to develop an automated OKC diagnostic system that can function as a decision support tool for pathologists, whether they are working locally or remotely. This system will provide them with additional data and insights to enhance their decision-making abilities. This research aims to provide an automation pipeline to classify whole-slide images of OKCs and non-keratocysts (non-KCs: dentigerous and radicular cysts). OKC diagnosis and prognosis using the histopathological analysis of tissues using whole-slide images (WSIs) with a deep-learning approach is an emerging research area. WSIs have the unique advantage of magnifying tissues with high resolution without losing information. The contribution of this research is a novel, deep-learning-based, and efficient algorithm that reduces the trainable parameters and, in turn, the memory footprint. This is achieved using principal component analysis (PCA) and the ReliefF feature selection algorithm (ReliefF) in a convolutional neural network (CNN) named P-C-ReliefF. The proposed model reduces the trainable parameters compared to standard CNN, achieving 97% classification accuracy.<\/jats:p>","DOI":"10.3390\/diagnostics13213384","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T14:51:01Z","timestamp":1699109461000},"page":"3384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Building Automation Pipeline for Diagnostic Classification of Sporadic Odontogenic Keratocysts and Non-Keratocysts Using Whole-Slide Images"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1698-6807","authenticated-orcid":false,"given":"Samahit","family":"Mohanty","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, M S Ramaiah University of Applied Sciences, Bengaluru 560054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-8615","authenticated-orcid":false,"given":"Divya B.","family":"Shivanna","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, M S Ramaiah University of Applied Sciences, Bengaluru 560054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopa S.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M S Ramaiah University of Applied Sciences, Bengaluru 560054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-411X","authenticated-orcid":false,"given":"Madhusudan","family":"Astekar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Institute of Dental Sciences, Bareilly 243006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetana","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology & Microbiology, Manipal College of Dental Sciences, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-4777","authenticated-orcid":false,"given":"Raghu","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology & Microbiology, Manipal College of Dental Sciences, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shylaja","family":"Sanjeevareddygari","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, SVS Institute of Dental Sciences, Mahbubnagar 509001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi","family":"Kotrashetti","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology & Microbiology, Maratha Mandal\u2019s Nathajirao G Halgekar, Institute of Dental Science & Research Centre, Belgaum 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology, Nijalingappa Institute of Dental Science & Research, Gulbarga 585105, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.9790\/0853-1604017982","article-title":"Classification of odontogenic cysts: A review","volume":"16","author":"Sumbh","year":"2017","journal-title":"IOSR J. 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