{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:07:38Z","timestamp":1784732858347,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We report the case of a 59-year-old female patient, a former smoker, who was diagnosed with bilateral pulmonary nodules. Extensive medical investigations were conducted, including a surgical lung biopsy, which led to the diagnosis of pulmonary amyloidoma. The diagnostic process was guided by the presence of a persistent, polymorphic, and nonspecific clinical picture, strengthened by imaging findings characterized by mixed nodular lesions and the addition of interstitial involvement, along with partial deterioration of the pulmonary parenchyma architecture. Although it is recognized as a benign tumor, pulmonary amyloidoma requires special care in order to rule out systemic involvement, association with lymphomas, or systemic amyloidosis. This case highlights the comprehensive investigations required in the presence of multiple pulmonary nodules and the wide range of possible diagnoses. It underscores the pivotal role of surgical lung biopsy and histopathological examination. The case is instructive, addressing a rare pathology, on the border between specialties, while also emphasizing potential evolving challenges and providing further insights into the clinical course of this disease.<\/jats:p>","DOI":"10.3390\/diagnostics13223411","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:08:58Z","timestamp":1699517338000},"page":"3411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pulmonary Amyloidoma: A Case Report and Brief Review of the Literature"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2334-9352","authenticated-orcid":false,"given":"Matache","family":"Radu \u0218erban","sequence":"first","affiliation":[{"name":"Department of Cardio-Thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Institute of Pneumology \u201cMarius Nasta\u201d, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-7805","authenticated-orcid":false,"given":"Savu Cornel","family":"Florentin","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Institute of Pneumology \u201cMarius Nasta\u201d, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin Ancuta","family":"Alina","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Institute of Pneumology \u201cMarius Nasta\u201d, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2054270414527280","DOI":"10.1177\/2054270414527280","article-title":"Thoracic amyloidomas: Two case reports of an evasive diagnosis","volume":"5","author":"Cresner","year":"2014","journal-title":"JRSM Open"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cottin, V., Richeldi, L., Brown, K., and McCormack, F.X. (2023). Orphan Lung Diseases, Springer.","DOI":"10.1007\/978-3-031-12950-6"},{"key":"ref_3","first-page":"101837","article-title":"A rare case of isolated thoracic AL-amyloidoma causing complete atelectasis of the right lung","volume":"43","author":"Rath","year":"2023","journal-title":"Respir. Med. Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"170046","DOI":"10.1183\/16000617.0046-2017","article-title":"The lung in amyloidosis","volume":"26","author":"Milani","year":"2017","journal-title":"Eur. Respir. Rev."},{"key":"ref_5","unstructured":"Mudambi, L., Johnson, M., and Kim, S. (2022). Murray & Nadel\u2019s Textbook of Respiratory Medicine, Elsevier-OHCE. [7th ed.]. Available online: https:\/\/bookshelf.health.elsevier.com\/books\/9780323655897."},{"key":"ref_6","first-page":"003586","article-title":"Spontaneous resolution of a pulmonary cystic amyloidosis mass","volume":"9","author":"Guediri","year":"2022","journal-title":"Eur. J. Case Rep. Intern. Med."},{"key":"ref_7","first-page":"101427","article-title":"Pulmonary amyloidosis mimicking interstitial lung disease and malignancy\u2014A case series with a review of a pulmonary patterns","volume":"33","author":"Zimna","year":"2021","journal-title":"Respir. Med. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"omaa134","DOI":"10.1093\/omcr\/omaa134","article-title":"A Unique Case of Combined Nodular and Tracheobronchial Amyloidosis","volume":"2021","author":"Ding","year":"2021","journal-title":"Oxf. Med. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1200\/OP.22.00396","article-title":"Diagnostic and Treatment Strategies for AL Amyloidosis in an Era of Therapeutic Innovation","volume":"19","author":"Dima","year":"2023","journal-title":"JCO Oncol. Pract."},{"key":"ref_10","first-page":"101820","article-title":"Isolated pulmonary amyloidoma: A rare cause of solitary pulmonary nodule","volume":"42","author":"DeCicco","year":"2023","journal-title":"Respir. Med. Case Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000506617","article-title":"When to Suspect a Diagnosis of Amyloidosis","volume":"143","author":"Vaxman","year":"2020","journal-title":"Acta Haematol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Dalpiaz, G., and Cancellieri, A. (2017). Atlas of Diffuse Lung Diseases, Springer.","DOI":"10.1007\/978-3-319-42752-2"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Liu, Y., Jin, Z., Zhang, H., Zhang, Y., Shi, M., Meng, F., Sun, Q., and Cai, H. (2018). Diffuse parenchymal pulmonary amyloidosis associated with multiple myeloma: A case report and systematic review of the literature. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4565-5"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2214\/ajr.158.2.1729778","article-title":"High-resolution CT appearance of diffuse alveolar septal amyloidosis","volume":"158","author":"Graham","year":"1992","journal-title":"Am. J. Roentgenol."},{"key":"ref_15","first-page":"1084063","article-title":"Tracheobronchial Amyloidosis Mimicking Tracheal Tumor","volume":"2016","author":"Uzun","year":"2016","journal-title":"Case Rep. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"A2508","DOI":"10.1016\/j.chest.2020.09.110","article-title":"A Case Report of Primary Amyloidoma of the Lung","volume":"158","author":"Hussain","year":"2020","journal-title":"Chest"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/22\/3411\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:20:04Z","timestamp":1760131204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/22\/3411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":16,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["diagnostics13223411"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13223411","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]}}}