{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:48:47Z","timestamp":1780426127578,"version":"3.54.1"},"reference-count":41,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Catholic University of Valencia","award":["2023-275-001"],"award-info":[{"award-number":["2023-275-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Thyroid dysfunction stands as the most prevalent endocrine disorder in individuals with Down syndrome, particularly showcasing both clinical and subclinical hypothyroidism. TSH and FT4 blood values serve as common diagnostic and treatment adjustment markers. In Down syndrome (DS), hormone values may deviate from those observed in the general population, which may lead to overdiagnosis and consequent iatrogenesis of subclinical hypothyroidism. The objective of this study was to analyze the appropriateness of the replacement therapeutic approach by identifying the TSH and FT4 values that can be considered normal in these patients. Methods: A cross-sectional study was conducted in 503 subjects with DS of both sexes and without age limit drawn from the Health Program for individuals with DS in Valencia (Spain) from February 1993 to November 2021. The exclusion criteria included hyperthyroidism, nodules, tumors, or individuals under treatment with drugs influencing iodine metabolism. The normality of data distribution was assessed using the Shapiro\u2013Wilk test. Outliers were detected using the Reed\u2019s criterion. Hormone values were estimated using quantile regression models for the 2.5th and 97.5th percentiles. Results: The normal values identified were 0.88\u201311.25 mIU\/L for TSH and 0.71\u20131.63 ng\/dL for FT4. The Wald test indicated no significant differences in the reference intervals based on age or sex. Conclusion: The establishment of these values, which, in people with DS, can be considered unique, is of great importance, allowing a watchful waiting attitude to be maintained before starting replacement therapy that is unnecessarily or adjusting medication in diagnosed cases.<\/jats:p>","DOI":"10.3390\/diagnostics13233499","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:12:13Z","timestamp":1700568733000},"page":"3499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is There an Adequate Therapeutic Approach to Thyroid Pathology in Patients with Down Syndrome?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-0443","authenticated-orcid":false,"given":"Maria Teresa","family":"Murillo-Llorente","sequence":"first","affiliation":[{"name":"SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-4785","authenticated-orcid":false,"given":"Marcelino","family":"P\u00e9rez-Bermejo","sequence":"additional","affiliation":[{"name":"SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Llacer-Heredia","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-8329","authenticated-orcid":false,"given":"Beatriz","family":"Tom\u00e1s-Aguirre","sequence":"additional","affiliation":[{"name":"CS Serreria II, Down Syndrome Unit\u2014Cl\u00ednico-Malvarrosa Department, Social Pediatrics Workgroup SVP, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Valls-Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"CS Nazaret Valencia, Cl\u00ednico-Malvarrosa Department, INCLIVA Nutrition Research Group, 46024 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Tom\u00e1s-Aguirre","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"ref_1","first-page":"132","article-title":"Thyroid disorders in subjects with Down syndrome: An update","volume":"89","author":"Amr","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/0971-5916.164218","article-title":"Oxidative stress, thyroid dysfunction & Down syndrome","volume":"142","author":"Campos","year":"2015","journal-title":"Ind. 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