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This comprehensive review provides a comprehensive overview of the utilization of Artificial Intelligence (AI) powered algorithms in the diagnosis of HD. This review systematically analyses the existing literature to identify key trends, methodologies, and challenges in this emerging field. It also highlights the potential of ML and DL approaches in automating HD diagnosis through the analysis of clinical, genetic, and neuroimaging data. This review also discusses the limitations and ethical considerations associated with these models and suggests future research directions aimed at improving the early detection and management of Huntington\u2019s disease. It also serves as a valuable resource for researchers, clinicians, and healthcare professionals interested in the intersection of machine learning and neurodegenerative disease diagnosis.<\/jats:p>","DOI":"10.3390\/diagnostics13233592","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T03:40:58Z","timestamp":1701661258000},"page":"3592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Exploring Huntington\u2019s Disease Diagnosis via Artificial Intelligence Models: A Comprehensive Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Sowmiyalakshmi","family":"Ganesh","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thillai","family":"Chithambaram","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-519X","authenticated-orcid":false,"given":"Nadesh Ramu","family":"Krishnan","sequence":"additional","affiliation":[{"name":"School of Computer Science Engineering and Information Systems, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7598-1363","authenticated-orcid":false,"given":"Durai Raj","family":"Vincent","sequence":"additional","affiliation":[{"name":"School of Computer Science Engineering and Information Systems, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-6667","authenticated-orcid":false,"given":"Jayakumar","family":"Kaliappan","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-0237","authenticated-orcid":false,"given":"Kathiravan","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bhachawat, S., Shriram, E., Srinivasan, K., and Hu, Y.C. 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