{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:57:51Z","timestamp":1789081071800,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish governmental grant \u2018Avtal om L\u00e4karutbildning och Forskning (ALF)\u2019, ALF-Stockholm County","award":["20150411"],"award-info":[{"award-number":["20150411"]}]},{"name":"Swedish governmental grant \u2018Avtal om L\u00e4karutbildning och Forskning (ALF)\u2019, ALF-Stockholm County","award":["20190202"],"award-info":[{"award-number":["20190202"]}]},{"name":"Swedish governmental grant \u2018Avtal om L\u00e4karutbildning och Forskning (ALF)\u2019, ALF-Stockholm County","award":["154112"],"award-info":[{"award-number":["154112"]}]},{"name":"Swedish governmental grant \u2018Avtal om L\u00e4karutbildning och Forskning (ALF)\u2019, ALF-Stockholm County","award":["181115"],"award-info":[{"award-number":["181115"]}]},{"name":"\u2018Konung Gustaf V Jubileumsfond\u2019, Radiumhemmet, Stockholm, Sweden","award":["20150411"],"award-info":[{"award-number":["20150411"]}]},{"name":"\u2018Konung Gustaf V Jubileumsfond\u2019, Radiumhemmet, Stockholm, Sweden","award":["20190202"],"award-info":[{"award-number":["20190202"]}]},{"name":"\u2018Konung Gustaf V Jubileumsfond\u2019, Radiumhemmet, Stockholm, Sweden","award":["154112"],"award-info":[{"award-number":["154112"]}]},{"name":"\u2018Konung Gustaf V Jubileumsfond\u2019, Radiumhemmet, Stockholm, Sweden","award":["181115"],"award-info":[{"award-number":["181115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In this study, we conducted a comparative analysis of demographic, histopathological, and sonographic characteristics between pre- and postmenopausal women diagnosed with endometrial cancer, while also examining sonographic and anthropometric features in \u2018low\u2019 and \u2018intermediate\/high-risk\u2019 cases, stratified by menopausal status. Our analysis, based on data from the International Endometrial Tumor Analysis (IETA) 4 cohort comprising 1538 women (161 premenopausal, 1377 postmenopausal) with biopsy-confirmed endometrial cancer, revealed that premenopausal women, compared to their postmenopausal counterparts, exhibited lower parity (median 1, IQR 0\u20132 vs. 1, IQR 1\u20132, p = 0.001), a higher family history of colon cancer (16% vs. 7%, p = 0.001), and smaller waist circumferences (median 92 cm, IQR 82\u2013108 cm vs. 98 cm, IQR 87\u2013112 cm, p = 0.002). Premenopausal women more often had a regular endometrial\u2013myometrial border (39% vs. 23%, p &lt; 0.001), a visible endometrial midline (23% vs. 11%, p &lt; 0.001), and undefined tumor (73% vs. 84%, p = 0.001). Notably, despite experiencing a longer duration of abnormal uterine bleeding (median 5 months, IQR 3\u201312 vs. 3 months, 2\u20136, p &lt; 0.001), premenopausal women more often had \u2018low\u2019 risk disease (78% vs. 46%, p &lt; 0.001). Among sonographic and anthropometric features, only an irregular endometrial\u2013myometrial border was associated with \u2018intermediate\/high\u2019 risk in premenopausal women. Conversely, in postmenopausal women, multiple features correlated with \u2018intermediate\/high\u2019 risk disease. Our findings emphasize the importance of considering menopausal status when evaluating sonographic features in women with endometrial cancer.<\/jats:p>","DOI":"10.3390\/diagnostics14010001","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T04:18:37Z","timestamp":1702959517000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sonographic, Demographic, and Clinical Characteristics of Pre- and Postmenopausal Women with Endometrial Cancer; Results from a Post Hoc Analysis of the IETA4 (International Endometrial Tumor Analysis) Multicenter Cohort"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-2447","authenticated-orcid":false,"given":"Rasmus W.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Education, Karolinska Institute, S\u00f6dersjukhuset, Sjukhusbacken 10, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-3218","authenticated-orcid":false,"given":"Daniela","family":"Fischerov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics and Neonatology, General University Hospital and First Faculty of Medicine, Charles University, Apolin\u00e1\u0159sk\u00e1 18, 128 51 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-8726","authenticated-orcid":false,"given":"Antonia C.","family":"Testa","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health, Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Department of Life Science and Public Health, Catholic University of Sacred Heart Largo Agostino Gemelli, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorella","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, European Institute of Oncology (IEO) IRCCS, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Fr\u00fchauf","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics and Neonatology, General University Hospital and First Faculty of Medicine, Charles University, Apolin\u00e1\u0159sk\u00e1 18, 128 51 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8235","authenticated-orcid":false,"given":"Pelle G.","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Karolinska Institute, S\u00f6dersjukhuset, Sjukhusbacken 10, 118 83 Stockholm, Sweden"},{"name":"Department of Obstetrics and Gynecology, S\u00f6dersjukhuset, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"di Legge","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-9356","authenticated-orcid":false,"given":"David","family":"Cibula","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics and Neonatology, General University Hospital and First Faculty of Medicine, Charles University, Apolin\u00e1\u0159sk\u00e1 18, 128 51 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-2194","authenticated-orcid":false,"given":"Robert","family":"Fruscio","sequence":"additional","affiliation":[{"name":"UO Gynecology, Department of Medicine and Surgery, IRCCS San Gerardo, University of Milan Bicocca, 20126 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-7968","authenticated-orcid":false,"given":"Lucia A.","family":"Haak","sequence":"additional","affiliation":[{"name":"Institute for the Care of Mother and Child, Prague and Third Faculty of Medicine, Charles University, 147 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-0758","authenticated-orcid":false,"given":"Gina","family":"Opolskiene","sequence":"additional","affiliation":[{"name":"Center of Obstetrics and Gynecology, Faculty of Medicine, Vilnius University Hospital, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-3098","authenticated-orcid":false,"given":"Ailyn M.","family":"Vidal Urbinati","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, European Institute of Oncology (IEO) IRCCS, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-6645","authenticated-orcid":false,"given":"Dirk","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Obstetrics and Gynecology, University Hospital Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Bourne","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Obstetrics and Gyneacology, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College London, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-5036","authenticated-orcid":false,"given":"Thierry","family":"van den Bosch","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Obstetrics and Gynecology, University Hospital Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-7785","authenticated-orcid":false,"given":"Elisabeth","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Karolinska Institute, S\u00f6dersjukhuset, Sjukhusbacken 10, 118 83 Stockholm, Sweden"},{"name":"Department of Obstetrics and Gynecology, S\u00f6dersjukhuset, 118 83 Stockholm, 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J. Gynecol. Obstet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_3","unstructured":"National Cancer Institute (NIH) (2019, October 30). Cancer Stat Facts: Endometrial Cancer, Available online: https:\/\/seer.cancer.gov\/statfacts\/html\/corp.html."},{"key":"ref_4","unstructured":"Cancer Research UK (2019, October 30). Available online: https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/uterine-cancer\/incidence#heading-One."},{"key":"ref_5","unstructured":"(2019, October 30). Socialstyrelsen, Statistikdatabas f\u00f6r Cancer. Available online: https:\/\/sdb.socialstyrelsen.se\/if_can\/val.aspx."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/1471-0528.14385","article-title":"Premenopausal Abnormal Uterine Bleeding and Risk of Endometrial Cancer","volume":"124","author":"Pennant","year":"2017","journal-title":"BJOG"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1001\/jamainternmed.2018.2820","article-title":"Association of Endometrial Cancer Risk with Postmenopausal Bleeding in Women a Systematic Review and Meta-Analysis","volume":"178","author":"Clarke","year":"2018","journal-title":"JAMA Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.ejca.2015.08.031","article-title":"Insulin Resistance and Endometrial Cancer Risk: A Systematic Review and Meta-Analysis","volume":"51","author":"Hernandez","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/oxfordjournals.aje.a008707","article-title":"Reproductive Factors and Risk of Endometrial Cancer. The Iowa Women\u2019s Health Study","volume":"143","author":"McPherson","year":"1996","journal-title":"Am. J. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/01.AOG.0000154151.14516.f7","article-title":"Risk Factors for Young Premenopausal Women With Endometrial Cancer","volume":"105","author":"Soliman","year":"2005","journal-title":"Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"689.e1","DOI":"10.1016\/j.ajog.2016.01.175","article-title":"Obesity and Endometrial Hyperplasia and Cancer in Premenopausal Women: A Systematic Review","volume":"214","author":"Wise","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ygyno.2005.06.029","article-title":"Endometrial Cancer in Young, Normal-Weight Women","volume":"99","author":"Schmeler","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/01.AOG.0000255980.88205.15","article-title":"Prognostic Factors for Uterine Cancer in Reproductive-Aged Women","volume":"109","author":"Lee","year":"2007","journal-title":"Obstet. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.ajog.2005.05.003","article-title":"Endometrial Cancer in Women 45 Years of Age or Younger: A Clinicopathological Analysis","volume":"193","author":"Pellerin","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdv484","article-title":"ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-Up","volume":"27","author":"Colombo","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/uog.20374","article-title":"Validation of Ultrasound Strategies to Assess Tumor Extension and to Predict High-Risk Endometrial Cancer in Women from the Prospective IETA (International Endometrial Tumor Analysis)-4 Cohort","volume":"55","author":"Verbakel","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/uog.18909","article-title":"Ultrasound Characteristics of Endometrial Cancer as Defined by International Endometrial Tumor Analysis (IETA) Consensus Nomenclature: Prospective Multicenter Study","volume":"51","author":"Epstein","year":"2018","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/uog.21950","article-title":"Ultrasound-Based Risk Model for Preoperative Prediction of Lymph-Node Metastases in Women with Endometrial Cancer: Model-Development Study","volume":"56","author":"Eriksson","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ygyno.2018.06.027","article-title":"Endometrial Cancer Off-Line Staging Using Two-Dimensional Transvaginal Ultrasound and Three-Dimensional Volume Contrast Imaging: Intermethod Agreement, Interrater Reliability and Diagnostic Accuracy","volume":"150","author":"Green","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/uog.7487","article-title":"Terms, Definitions and Measurements to Describe the Sonographic Features of the Endometrium and Intrauterine Lesions: A Consensus Opinion from the International Endometrial Tumor Analysis (IETA) Group","volume":"35","author":"Leone","year":"2010","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_21","first-page":"e28","article-title":"Clinical Data Miner: An Electronic Case Report Form System with Integrated Data Preprocessing and Machine-Learning Libraries Supporting Clinical Diagnostic Model Research","volume":"16","author":"Timmerman","year":"2014","journal-title":"J. Med. Internet Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","article-title":"Revised FIGO Staging for Carcinoma of the Vulva, Cervix, and Endometrium","volume":"105","author":"Pecorelli","year":"2009","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_23","unstructured":"Kurman, R.J., Carcangiu, M.L., Herrington, S.C., and Young, R.H. (2014). WHO Classification of Tumours of Female Reproductive Organs."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The Control of the False Discovery Rate in Multiple Testing under Dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann. Stat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/1536867X0300300202","article-title":"Multiple\u2014Test Procedures and Smile Plots","volume":"3","author":"Newson","year":"2003","journal-title":"Stata J. Promot. Commun. Stat. Stata"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1000182","DOI":"10.4172\/2161-1459.1000182","article-title":"Interpretation of Statistical Significance-Exploratory Versus Confirmative Testing in Clinical Trials, Epidemiological Studies, Meta-Analyses and Toxicological Screening (Using Ginkgo Biloba as an Example)","volume":"5","author":"Gaus","year":"2015","journal-title":"Clin. Exp. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/uog.12306","article-title":"Capacity of Endometrial Thickness Measurement to Diagnose Endometrial Carcinoma in Asymptomatic Postmenopausal Women: A Systematic Review and Meta-Analysis","volume":"40","author":"Breijer","year":"2012","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.21037\/apm-21-2516","article-title":"Capacity of Endometrial Thickness Measurement to Diagnose Endometrial Carcinoma in Asymptomatic Postmenopausal Women: A Systematic Review and Meta-Analysis","volume":"10","author":"Su","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/rmb2.12062","article-title":"Measurement of Endometrial Thickness in Premenopausal Women in Office Gynecology","volume":"17","author":"Tsuda","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.7150\/jca.21137","article-title":"Body Mass Index Is Negatively Associated with Endometrial Cancer Stage, Regardless of Subtype and Menopausal Status","volume":"9","author":"Gao","year":"2018","journal-title":"J. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/ijo.2012.94","article-title":"Obesity and Endometrial Cancer Survival: A Systematic Review","volume":"37","author":"Arem","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/AOG.0000000000000381","article-title":"Obesity and Age at Diagnosis of Endometrial Cancer","volume":"124","author":"Nevadunsky","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ygyno.2019.03.258","article-title":"Association of Obesity with Survival in Patients with Endometrial Cancer","volume":"154","author":"Miller","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_35","unstructured":"(2019, December 13). Eurostat. Available online: https:\/\/ec.europa.eu\/eurostat\/data\/database."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1210\/jc.2003-031578","article-title":"Body Size and Ethnicity Are Associated with Menstrual Cycle Alterations in Women in the Early Menopausal Transition: The Study of Women\u2019s Health across the Nation (SWAN) Daily Hormone Study","volume":"89","author":"Santoro","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41562-017-0189-z","article-title":"Redefine Statistical Significance","volume":"2","author":"Benjamin","year":"2018","journal-title":"Nat. Hum. Behav."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/19466315.2020.1845790","article-title":"It\u2019s the Selection\u2019s Fault\u2014Not the p-Values\u2019: A Comment on \u201cThe Role of p-Values in Judging the Strength of Evidence and Realistic Replication Expectations\u201d","volume":"13","author":"Benjamini","year":"2020","journal-title":"Stat. Biopharm. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/d41586-019-00857-9","article-title":"Scientists Rise up against Statistical Significance","volume":"567","author":"Amrhein","year":"2019","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s00259-019-04467-5","article-title":"The p Value Wars (Again)","volume":"46","author":"Dirnagl","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/d41586-019-00969-2","article-title":"Retiring Statistical Significance Would Give Bias a Free Pass","volume":"567","author":"Ioannidis","year":"2019","journal-title":"Nature"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/1\/1\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:12Z","timestamp":1760132472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/1\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["diagnostics14010001"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14010001","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]}}}