{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:47:29Z","timestamp":1760150849240,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The prognostic value of exercise stress test after complex left main (LM) coronary artery bifurcation (LM) stenting has been poorly investigated. To partially fill this gap in knowledge, we retrospectively analyzed the procedural and medical data of consecutive patients referred to our center for complex LM bifurcation disease between January 2008 and May 2018 who were treated using either single- or dual-stenting techniques. The prognostic impact of an exercise stress test, performed 6 months after the coronary intervention, was evaluated in 502 patients (316 males, mean age 70.3 \u00b1 12.8 years, mean Syntax score 31.6 \u00b1 6.3). At follow up after a mean of 37.1 \u00b1 10.8 months (range 22.1\u201347.3 months), the target lesion failure (TLF) rate was 10.1% while stent thrombosis and cardiovascular mortality were 1.2 and 3.6%, respectively. A positive exercise stress test was detected at 6-month follow up in 42 out of 502 patients (8.4%); the incidence of a significant restenosis was 7.6% (n = 38). Patients with a negative exercise stress test at 6-month follow up had higher freedom from TLF and improved survival compared to those with a positive exercise stress test.<\/jats:p>","DOI":"10.3390\/diagnostics14010059","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T05:43:15Z","timestamp":1703655795000},"page":"59","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of a Routine Six-Month Exercise Stress Test after Complex Left Main Bifurcation Percutaneous Intervention"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0920-5021","authenticated-orcid":false,"given":"Gianluca","family":"Rigatelli","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit, Division of Cardiology, Aulss6 Ospedali Riuniti Padova Sud, 35043 Monselice, Italy"},{"name":"Department of Specialistic Medicine, Division of Cardiology, Rovigo General Hospital, 45100 Rovigo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zuin","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Marchese","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Division of Cardiology, Aulss6 Ospedali Riuniti Padova Sud, 35043 Monselice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervis","family":"Hiso","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Division of Cardiology, Aulss6 Ospedali Riuniti Padova Sud, 35043 Monselice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Rodin\u00f2","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Division of Cardiology, Aulss6 Ospedali Riuniti Padova Sud, 35043 Monselice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loris","family":"Roncon","sequence":"additional","affiliation":[{"name":"Department of Specialistic Medicine, Division of Cardiology, Rovigo General Hospital, 45100 Rovigo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Pasquetto","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Division of Cardiology, Aulss6 Ospedali Riuniti Padova Sud, 35043 Monselice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1016\/S0140-6736(16)32052-9","article-title":"Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): A prospective, randomised, open-label, non-inferiority trial","volume":"388","author":"Holm","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1056\/NEJMoa1610227","article-title":"Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease","volume":"375","author":"Stone","year":"2016","journal-title":"N. 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