{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:40:01Z","timestamp":1783010401781,"version":"3.54.6"},"reference-count":148,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cystic fibrosis (CF) is primarily known for its pulmonary consequences, which are extensively explored in the existing literature. However, it is noteworthy that individuals with CF commonly display gastrointestinal (G-I) manifestations due to the substantial presence of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in the intestinal tract. Recognized as pivotal nonpulmonary aspects of CF, G-I manifestations exhibit a diverse spectrum. Identifying and effectively managing these manifestations are crucial for sustaining health and influencing the overall quality of life for CF patients. This review aims to synthesize existing knowledge, providing a comprehensive overview of the G-I manifestations associated with CF. Each specific G-I manifestation, along with the diagnostic methodologies and therapeutic approaches, is delineated, encompassing the impact of innovative treatments targeting the fundamental effects of CF on the G-I tract. The findings underscore the imperative for prompt diagnosis and meticulous management of G-I manifestations, necessitating a multidisciplinary team approach for optimal care and enhancement of the quality of life for affected individuals. In conclusion, the authors emphasize the urgency for further clinical studies to establish a more robust evidence base for managing G-I symptoms within the context of this chronic disease. Such endeavors are deemed essential for advancing understanding and refining the clinical care of CF patients with G-I manifestations.<\/jats:p>","DOI":"10.3390\/diagnostics14020228","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T05:42:31Z","timestamp":1705902151000},"page":"228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnosis and Management of Gastrointestinal Manifestations in Children with Cystic Fibrosis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-378X","authenticated-orcid":false,"given":"Dana-Teodora","family":"Anton-P\u0103duraru","sequence":"first","affiliation":[{"name":"Department of Mother and Child Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u1e63i, Romania"},{"name":"\u201cSf. Maria\u201d Children Emergency Hospital, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina Mariela","family":"Murgu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u1e63i, Romania"},{"name":"\u201cSf. Maria\u201d Children Emergency Hospital, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Iulia","family":"Bozomitu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u1e63i, Romania"},{"name":"\u201cSf. Maria\u201d Children Emergency Hospital, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana Elena","family":"M\u00eendru","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u1e63i, Romania"},{"name":"\u201cSf. Maria\u201d Children Emergency Hospital, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codru\u021ba Olimpiada","family":"Iliescu Hali\u021bchi","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u1e63i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-3053","authenticated-orcid":false,"given":"Felicia","family":"Trofin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Interdisciplinarity\u2013Microbiology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u1e63i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0673-0736","authenticated-orcid":false,"given":"Carmen Iulia","family":"Ciongradi","sequence":"additional","affiliation":[{"name":"\u201cSf. Maria\u201d Children Emergency Hospital, 700309 Iasi, Romania"},{"name":"2nd Department of Surgery, Pediatric Surgery and Orthopedics, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u1e63i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-4112","authenticated-orcid":false,"given":"Ioan","family":"S\u00e2rbu","sequence":"additional","affiliation":[{"name":"\u201cSf. Maria\u201d Children Emergency Hospital, 700309 Iasi, Romania"},{"name":"2nd Department of Surgery, Pediatric Surgery and Orthopedics, \u201cGrigore T. 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