{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:37:31Z","timestamp":1789087051908,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81570850"],"award-info":[{"award-number":["81570850"]}]},{"name":"National Natural Science Foundation of China","award":["82070988"],"award-info":[{"award-number":["82070988"]}]},{"name":"National Natural Science Foundation of China","award":["2016YFC1305604"],"award-info":[{"award-number":["2016YFC1305604"]}]},{"name":"Ministry of Science and Technology Foundation of China","award":["81570850"],"award-info":[{"award-number":["81570850"]}]},{"name":"Ministry of Science and Technology Foundation of China","award":["82070988"],"award-info":[{"award-number":["82070988"]}]},{"name":"Ministry of Science and Technology Foundation of China","award":["2016YFC1305604"],"award-info":[{"award-number":["2016YFC1305604"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Retinal vessels have been good predictive and prognostic imaging biomarkers for systemic or eye diseases. Numerous studies have shown that the two retinal vein occlusion entities may correlate with cardiovascular and cerebrovascular events or primary open-angle glaucoma. This study aims to investigate if there is a disparity in the correlations between branch RVO (BRVO) and central RVO (CRVO) with systemic disorders or POAG, thus explaining the pathogenic difference between BRVO and CRVO. This retrospective case-control study enrolled 59 RVO subjects (118 eyes), including 25 CRVO and 34 BRVO subjects, who received routine eye and brain MRI examinations. The geometric characteristics of the caliber of the retinal and cerebral blood vessels and the optic nerve subarachnoid space width (ONSASW) were measured. Multivariable logistic regression analysis showed that ONSASW at 3 mm behind the globe (p = 0.044) and the relative retinal venular calibers (p = 0.031) were independent risk factors for the CRVO-affected eyes group in comparison with the BRVO-affected eyes group after adjusting for age, duration of hypertension, BMI, and IOP. In the CRVO-affected eyes, narrower relative retinal arteriolar calibers (p = 0.041) and wider relative venular calibers (p = 0.011) were independent risk factors compared with the CRVO-contralateral normal eyes when adjusting for IOP. We concluded that BRVO may be more associated with cerebrovascular diseases, and CRVO may be correlated with primary angle glaucoma. The geometric characteristics difference between the retinal and cerebrovascular may explain the pathological difference between CRVO and BRVO.<\/jats:p>","DOI":"10.3390\/diagnostics14030267","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T04:05:46Z","timestamp":1706241946000},"page":"267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Distinctive Imaging Characteristics of Retinal and Cerebral Vessels between Central and Branch Retinal Vein Occlusion by MRI and AI-Based Image Analyzer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-5781","authenticated-orcid":false,"given":"Qiyun","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Tongren Hospital, Capital Medical University, Beijing 100730, China"},{"name":"Beijing Retinal and Choroidal Vascular Disorders Study Group, Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100176, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3372-0798","authenticated-orcid":false,"given":"Xinyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Tongren Hospital, Capital Medical University, Beijing 100730, China"},{"name":"Beijing Retinal and Choroidal Vascular Disorders Study Group, Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Tongren Hospital, Capital Medical University, Beijing 100730, China"},{"name":"Beijing Retinal and Choroidal Vascular Disorders Study Group, Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Tongren Hospital, Capital Medical University, Beijing 100730, China"},{"name":"Beijing Retinal and Choroidal Vascular Disorders Study Group, Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Tiantan Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Gu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Tongren Hospital, Capital Medical University, Beijing 100730, China"},{"name":"Beijing Retinal and Choroidal Vascular Disorders Study Group, Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Xie","sequence":"additional","affiliation":[{"name":"Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiguang","family":"Ling","sequence":"additional","affiliation":[{"name":"EVision Technology, Beijing 100085, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.survophthal.2018.04.005","article-title":"Ischemic retinal vein occlusion: Characterizing the more severe spectrum of retinal vein occlusion","volume":"63","author":"Khayat","year":"2018","journal-title":"Surv. 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