{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:12:56Z","timestamp":1791918776599,"version":"4.3.4"},"reference-count":22,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Committee Region \u00d6rebro County","award":["OLL-929762"],"award-info":[{"award-number":["OLL-929762"]}]},{"name":"Research Committee Region \u00d6rebro County","award":["OLL-935240"],"award-info":[{"award-number":["OLL-935240"]}]},{"name":"Research Committee Region \u00d6rebro County","award":["OLL-978046"],"award-info":[{"award-number":["OLL-978046"]}]},{"name":"Research Committee Region \u00d6rebro County","award":["SLS-974222"],"award-info":[{"award-number":["SLS-974222"]}]},{"name":"Research Fund of the Swedish Gastroenterological Society","award":["OLL-929762"],"award-info":[{"award-number":["OLL-929762"]}]},{"name":"Research Fund of the Swedish Gastroenterological Society","award":["OLL-935240"],"award-info":[{"award-number":["OLL-935240"]}]},{"name":"Research Fund of the Swedish Gastroenterological Society","award":["OLL-978046"],"award-info":[{"award-number":["OLL-978046"]}]},{"name":"Research Fund of the Swedish Gastroenterological Society","award":["SLS-974222"],"award-info":[{"award-number":["SLS-974222"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Abnormal visceral perception and motor function are often observed in patients with fecal incontinence, evacuation disorders and irritable bowel syndrome. The international anorectal physiology working group has proposed a standardization for anorectal function assessment, where rectal sensitivity testing is performed using an elastic balloon attached to a high-resolution anorectal manometry (HRAM) catheter. Rectal compliance, another component of rectal function evaluation, is a pressure\u2013volume relationship that refers to the rectum\u2019s ability to stretch and expand as it receives and holds fecal matter. There are no data available regarding the possibility of compliance testing using HRAM, although this is theoretically possible by correcting for the elastic balloon\u2019s intrinsic properties. The gold standard for measurement of visceral sensitivity and compliance is the rectal barostat, according to the procedure described by the European COST action GENIEUR group. Data on the agreement between the two different procedures are scarce. Hence, we performed a comparative study of the HRAM and barostat investigations in 26 healthy individuals. We hypothesized that by inflating the balloon before the examination, rectal compliance can be measured with HRAM investigations, and we examined correlations and levels of agreement between the methods. Our results demonstrate that assessing rectal compliance with HRAM is technically possible; however, a strong correlation with the rectal barostat was only observed at the maximum tolerable volume (Spearman\u2019s rho = 0.7, p = 0.02). We only found moderate correlations (Spearman\u2019s rho = 0.562, p = 0.019) for compliance according to the barostat methodology and for rectal sensibility testing (Spearman\u2019s rho = 0.57, p = 0.03 for maximum tolerable volume). Bland\u2013Altman plots showed poor levels of agreement between the methods. We conclude that HRAM and the rectal barostat cannot be used interchangeably for compliance or sensitivity assessments. We suggest the development of a non-elastic balloon with a fixed size and shape to assess rectal sensory function and compliance in HRAM testing.<\/jats:p>","DOI":"10.3390\/diagnostics14040351","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T05:36:43Z","timestamp":1707197803000},"page":"351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rectal Sensory and Compliance Testing: A Method Comparison Study between High-Resolution Anorectal Manometry and Barostat Investigations"],"prefix":"10.3390","volume":"14","author":[{"given":"Lucian","family":"Marinica Grando","sequence":"first","affiliation":[{"name":"Department Gastroenterology, Faculty of Medicine and Health, \u00d6rebro University, SE 7082 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-7234","authenticated-orcid":false,"given":"Jonas","family":"Halfvarson","sequence":"additional","affiliation":[{"name":"Department Gastroenterology, Faculty of Medicine and Health, \u00d6rebro University, SE 7082 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"van Nieuwenhoven","sequence":"additional","affiliation":[{"name":"Department Gastroenterology, Faculty of Medicine and Health, \u00d6rebro University, SE 7082 \u00d6rebro, Sweden"},{"name":"University Health Care Research Center, Faculty of Medicine and Health, \u00d6rebro University, SE 70182 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s10620-012-2071-1","article-title":"The Physiology of Human Defecation","volume":"57","author":"Palit","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1136\/gut.2005.071613","article-title":"Rectal sensorimotor dysfunction in patients with urge faecal incontinence: Evidence from prolonged manometric studies","volume":"54","author":"Chan","year":"2005","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.gtc.2008.06.010","article-title":"Manometric, Sensorimotor, and Neurophysiologic Evaluation of Anorectal Function","volume":"37","author":"Scott","year":"2008","journal-title":"Gastroenterol. Clin. N. 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Epidemiol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/4\/351\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:55:41Z","timestamp":1760104541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/4\/351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["diagnostics14040351"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14040351","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]}}}