{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:59:24Z","timestamp":1783051164154,"version":"3.54.6"},"reference-count":188,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de N\u00e9phrologie, Dialyse et Transplantation","award":["2023"],"award-info":[{"award-number":["2023"]}]},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de N\u00e9phrologie, Dialyse et Transplantation","award":["2023\u20132024"],"award-info":[{"award-number":["2023\u20132024"]}]},{"name":"Ann\u00e9e Recherche","award":["2023"],"award-info":[{"award-number":["2023"]}]},{"name":"Ann\u00e9e Recherche","award":["2023\u20132024"],"award-info":[{"award-number":["2023\u20132024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Chronic Cardiovascular and Kidney Disorder (CCKD) represents a growing challenge in healthcare, characterized by the complex interplay between heart and kidney diseases. This manuscript delves into the \u201cbutterfly effect\u201d in CCKD, a phenomenon in which acute injuries in one organ lead to progressive dysfunction in the other. Through extensive review, we explore the pathophysiology underlying this effect, emphasizing the roles of acute kidney injury (AKI) and heart failure (HF) in exacerbating each other. We highlight emerging therapies, such as renin\u2013angiotensin\u2013aldosterone system (RAAS) inhibitors, SGLT2 inhibitors, and GLP1 agonists, that show promise in mitigating the progression of CCKD. Additionally, we discuss novel therapeutic targets, including Galectin-3 inhibition and IL33\/ST2 pathway modulation, and their potential in altering the course of CCKD. Our comprehensive analysis underscores the importance of recognizing and treating the intertwined nature of cardiac and renal dysfunctions, paving the way for more effective management strategies for this multifaceted syndrome.<\/jats:p>","DOI":"10.3390\/diagnostics14050463","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:50:07Z","timestamp":1708429807000},"page":"463","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Unraveling Chronic Cardiovascular and Kidney Disorder through the Butterfly Effect"],"prefix":"10.3390","volume":"14","author":[{"given":"Dimitri","family":"Bedo","sequence":"first","affiliation":[{"name":"Nephrology Department, Hopitaux Universitaires de Strasbourg, F-67091 Strasbourg, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, Team 3072 \u201cMitochondria, Oxidative Stress and Muscle Protection\u201d, Translational Medicine Federation of Strasbourg (FMTS), F-67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Beaudrey","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hopitaux Universitaires de Strasbourg, F-67091 Strasbourg, France"},{"name":"Laboratoire d\u2019ImmunoRhumatologie Mol\u00e9culaire, INSERM UMR_S 1109, Facult\u00e9 de M\u00e9decine, F\u00e9d\u00e9ration Hospitalo-Universitaire OMICARE, ITI TRANSPLANTEX NG, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Universit\u00e9 de Strasbourg, F-67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-6055","authenticated-orcid":false,"given":"Nans","family":"Florens","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hopitaux Universitaires de Strasbourg, F-67091 Strasbourg, France"},{"name":"Laboratoire d\u2019ImmunoRhumatologie Mol\u00e9culaire, INSERM UMR_S 1109, Facult\u00e9 de M\u00e9decine, F\u00e9d\u00e9ration Hospitalo-Universitaire OMICARE, ITI TRANSPLANTEX NG, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Universit\u00e9 de Strasbourg, F-67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1093\/eurheartj\/ehw334","article-title":"Cardiovascular disease in Europe: Epidemiological update 2016","volume":"37","author":"Townsend","year":"2016","journal-title":"Eur. 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