{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T17:55:42Z","timestamp":1786902942348,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Ectopic pregnancies are a frequently encountered cause of first-trimester metrorrhagia. They occur when an embryo is implanted and grows outside the normal uterine space. Uncommonly, the embryo can be implanted in the intramural portion of the uterine tube, a condition referred to as interstitial localization. This specific type of ectopic pregnancy may have an unpredictable course, potentially leading to severe uterine rupture and catastrophic bleeding if not promptly diagnosed and managed. We present a rare case of a multiparous 36-year-old female patient who underwent pelvic ultrasonography in the emergency department for intense pelvic pain associated with hypotension and moderate anemia. A history of right salpingectomy for a ruptured tubal ectopic pregnancy 10 years previously was noted. High beta-HCG levels were also detected. A pelvic ultrasound allowed us to suspect a ruptured ectopic interstitial pregnancy at 8 weeks of amenorrhea. An association with hemoperitoneum was suspected, and an emergency laparoscopy was performed. The condition was confirmed intraoperatively, and the patient underwent a right corneal wedge resection with suture of the uterine myometrium. The postoperative course was uneventful, and the patient was discharged on the fourth day postoperatively. Interstitial ectopic pregnancy is a rare yet extremely perilous situation. Timely ultrasound-based diagnosis is crucial as it can enable conservative management with Methotrexate. Delayed diagnosis can lead to uterine rupture with consecutive surgery based on a transection of the pregnancy and cornual uterine resection.<\/jats:p>","DOI":"10.3390\/diagnostics14050506","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T11:52:55Z","timestamp":1709034775000},"page":"506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ruptured Recurrent Interstitial Ectopic Pregnancy Successfully Managed by Laparoscopy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8176-0434","authenticated-orcid":false,"given":"Claudiu Octavian","family":"Ungureanu","sequence":"first","affiliation":[{"name":"Department of Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37, Dionisie Lupu Street, 020021 Bucharest, Romania"},{"name":"General Surgery Department, \u201cSf. Ioan\u201d Clinical Emergency Hospital, 13 Vitan-B\u00e2rze\u015fti Road, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5366-5684","authenticated-orcid":false,"given":"Floris Cristian","family":"Stanculea","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37, Dionisie Lupu Street, 020021 Bucharest, Romania"},{"name":"General Surgery Department, \u201cSf. Ioan\u201d Clinical Emergency Hospital, 13 Vitan-B\u00e2rze\u015fti Road, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niculae","family":"Iordache","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37, Dionisie Lupu Street, 020021 Bucharest, Romania"},{"name":"General Surgery Department, \u201cSf. Ioan\u201d Clinical Emergency Hospital, 13 Vitan-B\u00e2rze\u015fti Road, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor Florin","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37, Dionisie Lupu Street, 020021 Bucharest, Romania"},{"name":"General Surgery Department, Clinical Emergency Hospital Bucharest, SplaiulIndependentei nr 168, Sect 5, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octav","family":"Ginghina","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37, Dionisie Lupu Street, 020021 Bucharest, Romania"},{"name":"General Surgery Department, \u201cProf. Dr. Alexandru Trestioreanu\u201d Oncological Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-9490","authenticated-orcid":false,"given":"Raul","family":"Mihailov","sequence":"additional","affiliation":[{"name":"General Surgery Department, \u201cSf. Andrei\u201d Clinical Emergency Hospital, 177 Braila Street, 800578 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana Adela","family":"Vacaroiu","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37, Dionisie Lupu Street, 020021 Bucharest, Romania"},{"name":"Nephrology and Dialysis Clinic, \u201cSf. Ioan\u201d Emergency Clinical Hospital, Sos. Vitan-Barzesti nr 12, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5389-2254","authenticated-orcid":false,"given":"Dragos Eugen","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37, Dionisie Lupu Street, 020021 Bucharest, Romania"},{"name":"General Surgery Department, \u201cDr. I. Cantacuzino\u201d Clinical Hospital, 5-7 I. Movila Street, 022904 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gmit.2015.09.006","article-title":"Expect the unexpected: The dilemmas in the diagnosis and management of interstitial ectopic pregnancy\u2014Case report and literature review","volume":"5","author":"Kalidindi","year":"2016","journal-title":"Gynecol. Minim. Invasive Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0974-1208.44116","article-title":"Interstitial ectopic pregnancy: A rare and difficult clinicosonographic diagnosis","volume":"1","author":"Rastogi","year":"2008","journal-title":"J. Hum. Reprod. 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