{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:45:23Z","timestamp":1774266323627,"version":"3.50.1"},"reference-count":74,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Granulomatosis with polyangiitis (GPA) is characterised by granulomatous inflammation and small-to-medium vessel necrotising vasculitis, mainly affecting respiratory tract and kidneys. Renal involvement presenting as tumour-like lesions poses diagnostic and treatment challenges. Methods: Following the observation of a GPA patient presenting with multiple renal tumour-like lesions, we conducted a systematic literature review on MEDLINE\/PubMed, EMBASE, and Cochrane databases. Data gathered from the literature were analysed to summarise the diagnostic approach, management, and outcome of renal GPA-related tumour-like lesions. Results: a 49-year-old female presented with persistent constitutional symptoms and multiple bilateral renal lesions. Renal biopsy showed chronic interstitial inflammation with necrotising granulomas. Laboratory tests disclosed positive anti-proteinase 3 (PR3) anti-neutrophil cytoplasmic antibody (ANCA) leading to a final diagnosis of GPA. She was effectively treated with high-dose glucocorticoids and rituximab. Literature search yielded 41 articles, concerning 42 GPA patients with renal masses, presenting bilaterally in 23.8% of the cases. Positive PR3-ANCA was observed in 86.5% of the cases. Half of 42 patients showed kidney abnormalities. Treatment with glucocorticoids (83.3%) and immunosuppressive agents (80.9%) resulted in an overall good remission rate and favourable prognosis. Conclusions: GPA should be considered in the differential diagnoses of kidney tumour-like lesions. The diagnosis is challenging, and histological examination greatly contributes to the diagnostic work-up.<\/jats:p>","DOI":"10.3390\/diagnostics14050566","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T08:43:14Z","timestamp":1709714594000},"page":"566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cutting-Edge Strategies for Renal Tumour-like Lesions in Granulomatosis with Polyangiitis: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Luca","family":"Iorio","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-7317","authenticated-orcid":false,"given":"Marco","family":"Pizzi","sequence":"additional","affiliation":[{"name":"Surgical Pathology and Cytopathology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-1924","authenticated-orcid":false,"given":"Diego","family":"Cecchin","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Davanzo","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ghirardello","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Paolo","family":"Dei Tos","sequence":"additional","affiliation":[{"name":"Surgical Pathology and Cytopathology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-4983","authenticated-orcid":false,"given":"Andrea","family":"Doria","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-375X","authenticated-orcid":false,"given":"Roberto","family":"Padoan","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0394632015617063","article-title":"Clinic manifestations in granulomatosis with polyangiitis","volume":"29","author":"Greco","year":"2016","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103018","DOI":"10.1016\/j.autrev.2021.103018","article-title":"Current clinical and therapeutic approach to tumour-like mass lesions in granulomatosis with polyangiitis","volume":"21","author":"Padoan","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.autrev.2012.08.006","article-title":"Renal involvement in anti-neutrophil cytoplasmic autoantibody associated vasculitis","volume":"12","author":"Sinico","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"ref_5","first-page":"201","article-title":"Renal involvement at baseline can predict major renal relapse in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis","volume":"38","author":"Felicetti","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Nicolau, C., Antunes, N., Pa\u00f1o, B., and Sebastia, C. (2021). Imaging Characterization of Renal Masses. Medicina, 57.","DOI":"10.3390\/medicina57010051"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bmjebm-2017-110853","article-title":"Methodological quality and synthesis of case series and case reports","volume":"23","author":"Murad","year":"2018","journal-title":"BMJ Evid. Based Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: Explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J. Clin. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4103\/ijn.IJN_325_20","article-title":"Granulomatosis with Polyangiitis Masquerading as Renal Mass: Case Report and Literature Review","volume":"31","author":"Tiwari","year":"2021","journal-title":"Indian J. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2214\/ajr.130.2.233","article-title":"Unusual radiographic features of Wegener\u2032s granulomatosis","volume":"130","author":"Maguire","year":"1978","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0090-4295(86)90012-9","article-title":"Wegener granulomatosis presenting as renal mass","volume":"28","author":"Schapira","year":"1986","journal-title":"Urology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3109\/03009749209099223","article-title":"Wegener\u2019s granulomatosis presenting with a tumor-like lesion in the kidney","volume":"21","author":"Schydlowsky","year":"1992","journal-title":"Scand. J. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1464-410X.1993.tb16319.x","article-title":"An unusual renal mass? Wegener\u2032s granulomatosis","volume":"72","author":"Smith","year":"1993","journal-title":"Br. J. Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1159\/000188314","article-title":"Wegener\u2032s granulomatosis limited to the kidney as a masslike lesion","volume":"68","author":"Boubenider","year":"1994","journal-title":"Nephron"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2214\/ajr.174.6.1741597","article-title":"Wegener\u2019s granulomatosis presenting as a renal mass","volume":"174","author":"Fairbanks","year":"2000","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/MD.0b013e318239add6","article-title":"Urogenital manifestations in Wegener granulomatosis: A study of 11 cases and review of the literature","volume":"91","author":"Dufour","year":"2012","journal-title":"Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0248-8663(83)80007-1","article-title":"Tumorous form of Wegener\u2019s granulomatosis following a malignant facial granuloma. Diagnostic value","volume":"4","author":"Thomas","year":"1983","journal-title":"Rev. Med. Interne"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s003300000344","article-title":"Granulomatous renal pseudotumor in Wegener\u2019s granulomatosis: Imaging findings in one case","volume":"10","author":"Verswijvel","year":"2000","journal-title":"Eur. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2214\/ajr.176.1.1760116","article-title":"Multiple renal masses as initial manifestation of Wegener\u2019s granulomatosis","volume":"176","author":"Marquez","year":"2001","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0002-9343(01)00946-9","article-title":"Wegener\u2019s granulomatosis presenting as multiple kidney masses","volume":"112","author":"Kapoor","year":"2002","journal-title":"Am. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/ndt\/gfh058","article-title":"Wegener\u2032s granulomatosis presenting as multiple bilateral renal masses","volume":"19","author":"Leung","year":"2004","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1007\/s00247-011-2145-9","article-title":"A rare presentation of renal Wegener granulomatosis in a child","volume":"41","author":"Lerut","year":"2011","journal-title":"Pediatr. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.urology.2004.10.018","article-title":"Wegener\u2032s granulomatosis presenting as renal mass: A case for nephron-sparing surgery","volume":"65","author":"Krambeck","year":"2005","journal-title":"Urology"},{"key":"ref_25","first-page":"584","article-title":"Wegener\u2019s granulomatosis masquerading as a renal cancer: A case report and review of the literature","volume":"24","author":"Vandergheynst","year":"2006","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.amjmed.2015.05.009","article-title":"From polyuria to renal mass: An unexpected link","volume":"128","author":"Vandergheynst","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_27","first-page":"793014","article-title":"Renal Solid Mass as a Rare Presentation of Wagener\u2019s Granulomatosis: A Case Report","volume":"2012","author":"Hadi","year":"2012","journal-title":"Case Rep. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/rheumatology\/kel219","article-title":"Wegener\u2032s granulomatosis presenting as a disappearing renal mass","volume":"45","author":"Negi","year":"2006","journal-title":"Rheumatology"},{"key":"ref_29","first-page":"S138","article-title":"Granulomatosis with polyangiitis presenting as a renal mass successfully treated with rituximab","volume":"32","author":"Bajocchi","year":"2014","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00296-008-0715-4","article-title":"Wegener\u2019s granulomatosis presenting as multiple bilateral renal masses: Case report and literature review","volume":"29","author":"Frigui","year":"2009","journal-title":"Rheumatol. Int."},{"key":"ref_31","first-page":"7734","article-title":"Clinicopathological analysis of renal inflammatory pseudotumors presenting as the unilateral solitary masses","volume":"10","author":"Xu","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"547.e1","DOI":"10.1016\/j.urology.2007.11.046","article-title":"Wegener\u2032s granulomatosis presenting as a renal mass","volume":"71","author":"Roussou","year":"2008","journal-title":"Urology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1440-1797.2011.01472.x","article-title":"A young woman with fever, weight loss and a renal mass","volume":"16","author":"Ahmed","year":"2011","journal-title":"Nephrology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1097\/PAS.0000000000000294","article-title":"Granulomatosis with polyangiitis presenting as a renal tumor","volume":"38","author":"Ward","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.radcr.2023.01.001","article-title":"Granulomatosis with polyangiitis presenting as multiple renal masses: A case report with MRI findings","volume":"18","author":"Yamamoto","year":"2023","journal-title":"Radiol. Case Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/RLU.0000000000001746","article-title":"Occult Renal Granulomatous Inflammatory Lesions in Granulomatosis with Polyangiitis Detected by 18F-FDG PET\/CT","volume":"42","author":"Fu","year":"2017","journal-title":"Clin. Nucl. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Higashihara, M., Kawamura, T., Miyazaki, Y., Yokoo, T., and Joh, K. (2023). Granulomatosis with polyangiitis presenting as a solitary renal mass: A case report. BMC Nephrol., 24.","DOI":"10.1186\/s12882-023-03276-1"},{"key":"ref_38","first-page":"161","article-title":"Unusual unilateral renal mass with pulmonary multiple nodules as the initial presentation of granulomatosis with polyangiitis","volume":"24","author":"Dai","year":"2021","journal-title":"Hell. J. Nucl. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"200312","DOI":"10.1016\/j.ehpc.2019.200312","article-title":"Vasculitis manifested with multiple mass lesions in kidneys, lungs and soft tissue, mimicking malignant tumors","volume":"17","author":"Guo","year":"2019","journal-title":"Human. Pathol. Case Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"055","DOI":"10.1055\/s-0042-1760352","article-title":"Granulomatosis with Polyangiitis Presenting as a Renal Mass: A Scarce Case Report with a Review of the Literature","volume":"59","author":"Kumar","year":"2023","journal-title":"Ann. Natl. Acad. Med. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ehpc.2017.06.002","article-title":"Granulomatosis with polyangiitis presenting as a renal mass mimicking immunoglobulin G4-related disease","volume":"10","author":"Reeders","year":"2017","journal-title":"Human. Pathol. Case Rep."},{"key":"ref_42","first-page":"457","article-title":"Wegener\u2032s granulomatosis presenting with a renal mass","volume":"26","author":"Hoffman","year":"1999","journal-title":"J. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/24725625.2020.1782028","article-title":"Simultaneous presentation of granulomatosis with polyangiitis (GPA) and immunoglobulin G4-related disease (IgG4-RD). Leaving an open question: Widening the spectrum of a single disease or real overlap?","volume":"5","author":"Boncoraglio","year":"2021","journal-title":"Mod. Rheumatol. Case Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1681\/ASN.20223311S1168b","article-title":"Granulomatosis With Polyangiitis (GPA) Presenting as a Renal Mass in a Young Man with a Solitary Kidney","volume":"33","author":"Abudaff","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_45","first-page":"93","article-title":"An unusual case of Wegener\u2032s granulomatosis presenting with mass lesions of breast, spleen and kidney","volume":"117","author":"Bicakcigil","year":"2009","journal-title":"APMIS"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"kez058.020","DOI":"10.1093\/rheumatology\/kez058.020","article-title":"Multiple kidney masses in a young man","volume":"58","author":"Gregorini","year":"2019","journal-title":"Rheumatology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1681\/ASN.20203110S1549a","article-title":"A case of granulomatosis with polyangiitis complicated by renal mass-like lesion","volume":"31","author":"Kaikoi","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_48","first-page":"A5130","article-title":"The Bugs Were Not to Blame; Granulomatosis with Polyangiitis Camouflaging as a Renal Abscess","volume":"205","author":"Pednekar","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_49","first-page":"493","article-title":"Granulomatosis with polyangiitis (GPA) presenting as renal mass lesion: A case report","volume":"43","author":"Ramasamy","year":"2021","journal-title":"Malays. J. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"A109","DOI":"10.1053\/j.ajkd.2010.02.316","article-title":"Endocarditis and kidney mass in Wegener\u2032s granulomatosis","volume":"55","author":"Varkala","year":"2010","journal-title":"Am. J. Kidney Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s00296-023-05419-x","article-title":"Coexistence of IgG4-related disease and ANCA-associated vasculitis: Case report and review of the literature","volume":"44","author":"Korkmaz","year":"2023","journal-title":"Rheumatol. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jaut.2018.10.001","article-title":"Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases","volume":"97","author":"Salvarani","year":"2019","journal-title":"J. Autoimmun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00005792-200011000-00001","article-title":"Systemic vasculitis presenting as a tumorlike lesion. Four case reports and an analysis of 79 reported cases","volume":"79","author":"Kariv","year":"2000","journal-title":"Medicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1191\/0961203305lu2208oa","article-title":"Beh\u00e7et\u2032s disease and cardiovascular involvement","volume":"14","author":"Atzeni","year":"2005","journal-title":"Lupus"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00296-009-0911-x","article-title":"Renal cell carcinoma associated immunosuppressive therapy: A case report with Wegener\u2032s granulomatosis","volume":"30","author":"Deger","year":"2009","journal-title":"Rheumatol. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3109\/03009749609065652","article-title":"Renal cell carcinoma associated with cyclophosphamide therapy for Wegener\u2032s granulomatosis","volume":"25","author":"Odeh","year":"1996","journal-title":"Scand. J. Rheumatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2","DOI":"10.15761\/NRD.1000189","article-title":"Granulomatosis with polyangiitis and renal cell cancer: A sinister association\u2014Case report and review of literature","volume":"6","author":"Fawad","year":"2021","journal-title":"Nephrol. Renal. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1477-7819-9-165","article-title":"Renal cancer and Wegener\u2032s granulomatosis: A case report","volume":"9","author":"Bumbasirevic","year":"2011","journal-title":"World J. Surg. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/1529-0131(199904)42:4<751::AID-ANR19>3.0.CO;2-D","article-title":"Wegener\u2032s granulomatosis associated with renal cell carcinoma","volume":"42","author":"Tatsis","year":"1999","journal-title":"Arthritis Rheum."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/rheumatology\/kep009","article-title":"Cancer preceding Wegener\u2032s granulomatosis: A case-control study","volume":"48","author":"Faurschou","year":"2009","journal-title":"Rheumatology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrrheum.2014.103","article-title":"Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease","volume":"10","author":"Jennette","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.autrev.2010.02.006","article-title":"Wegener\u2032s Granulomatosis vasculitis and granuloma","volume":"9","author":"Schilder","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_63","first-page":"S90","article-title":"A novel system to test for specificity of B cell receptors from tissue of Wegener\u2032s granulomatosis patients","volume":"26","author":"Voswinkel","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jaut.2016.12.004","article-title":"Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis","volume":"78","author":"Kerstein","year":"2017","journal-title":"J. Autoimmun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41584-018-0145-y","article-title":"Pathogenesis and therapeutic interventions for ANCA-associated vasculitis","volume":"15","author":"Nakazawa","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41584-023-00943-3","article-title":"PR3 triggers granuloma formation in GPA","volume":"19","author":"Onuora","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1136\/ard-2021-221800","article-title":"Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis","volume":"82","author":"Henderson","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1148\/radiology.174.3.2305053","article-title":"Thoracic manifestations of Wegener granulomatosis: Diagnosis and course","volume":"174","author":"Aberle","year":"1990","journal-title":"Radiology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/ard-2022-223764","article-title":"EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update","volume":"83","author":"Hellmich","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/art.41773","article-title":"2021 American College of Rheumatology\/Vasculitis Foundation Guideline for the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis","volume":"73","author":"Chung","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1136\/annrheumdis-2015-208073","article-title":"Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type","volume":"75","author":"Unizony","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.autrev.2019.03.001","article-title":"Ocular involvement in granulomatosis with polyangiitis: A single-center cohort study on 63 patients","volume":"18","author":"Charles","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ajo.2021.06.030","article-title":"Fluctuations in Central Subfield Thickness Associated with Worse Visual Outcomes in Patients with Diabetic Macular Edema in Clinical Trial Setting","volume":"232","author":"Starr","year":"2021","journal-title":"Am. J. 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