{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:53:32Z","timestamp":1760144012103,"version":"build-2065373602"},"reference-count":15,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Health of Russia","award":["122020900122-7"],"award-info":[{"award-number":["122020900122-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A 12-year-old adolescent was diagnosed with a right-sided solid mass in the round ligament of the uterus. The chief complaints were abdominal pain and pelvic discomfort. She underwent laparoscopic tumor resection. Histological examination demonstrated a trabecular growth pattern of epithelioid cells with mitotic activity (3 per 50 HPF), which expressed melanocytic and myoid markers. Due to aforementioned findings, a final diagnosis of perivascular epithelioid cell tumor (PEComa) with uncertain malignant potential was made. To the best of our knowledge, this localization of PEComa is considered to be infrequent with only occasionally reported cases.<\/jats:p>","DOI":"10.3390\/diagnostics14060616","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:02:39Z","timestamp":1710504159000},"page":"616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perivascular Epithelioid Cell Tumor with Uncertain Malignant Potential Arising in the Round Ligament"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5223-9767","authenticated-orcid":false,"given":"Alina","family":"Badlaeva","sequence":"first","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, Moscow 117513, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Tregubova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, Moscow 117513, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Kruglyak","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, Moscow 117513, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Luzhina","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, Moscow 117513, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-5209","authenticated-orcid":false,"given":"Aleksandra","family":"Asaturova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, Moscow 117513, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/PAS.0000000000001119","article-title":"Uterine PEComas","volume":"42","author":"Bennett","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_2","first-page":"7","article-title":"Evidence on the neural crest origin of PEComas","volume":"52","year":"2011","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2147\/OTT.S300523","article-title":"A Retrospective Case Study of 13 Uterine Perivascular Epithelioid Cell Neoplasm (PEComa) Patients","volume":"14","author":"Gu","year":"2021","journal-title":"OncoTargets Ther."},{"key":"ref_4","first-page":"44","article-title":"Broad ligament perivascular epithelioid cell tumor (pecoma) of uncertain malignant potential","volume":"32","author":"Mathew","year":"2016","journal-title":"Turk. J. Pathol."},{"key":"ref_5","first-page":"211","article-title":"Perivascular epithelioid tumor (PEComa) of the falciform\/broad ligament","volume":"59","author":"Karolewski","year":"2008","journal-title":"Pol. J. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1048-891X.2004.014549.x","article-title":"Malignant perivascular epithelioid cell tumor (PEComa) arising in the broad ligament","volume":"14","author":"Fink","year":"2004","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.anndiagpath.2015.06.003","article-title":"PEComa: Morphology and genetics of a complex tumor family","volume":"19","author":"Thway","year":"2015","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/1752-1947-5-383","article-title":"A patient presenting with a perivascular epithelioid cell tumor in the broad ligament: A case report","volume":"5","author":"Ross","year":"2011","journal-title":"J. Med. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e14072","DOI":"10.1097\/MD.0000000000014072","article-title":"Malignant perivascular epithelioid cell tumor in the female genital tract","volume":"98","author":"Liu","year":"2019","journal-title":"Medicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/PAS.0000000000000133","article-title":"Perivascular Epithelioid Cell Neoplasm (PEComa) of the Gynecologic Tract","volume":"38","author":"Schoolmeester","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_11","unstructured":"Lokuhetty, D., White, V.A., and Watanabe, R. (2020). Female Genital Tumours, Internal Agency for Research on Cancer (IARC). [5th ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cao, B., and Huang, Y. (2022). Malignant perivascular epithelioid cell tumor (PEComa) of the uterus. BMC Women\u2019s Health, 22.","DOI":"10.1186\/s12905-022-02119-9"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bourgmayer, A., Nannini, S., Bonjean, P., Kurtz, J.-E., Malouf, G.G., and Gantzer, J. (2021). Natural History and Treatment Strategies of Advanced PEComas: A Systematic Review. Cancers, 13.","DOI":"10.3390\/cancers13205227"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/PAS.0000000000000349","article-title":"TFE3 Translocation\u2013associated Perivascular Epithelioid Cell Neoplasm (PEComa) of the Gynecologic Tract","volume":"39","author":"Schoolmeester","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2147\/CMAR.S351284","article-title":"Management Strategies for Adults with Locally Advanced, Unresectable or Metastatic Malignant Perivascular Epithelioid Cell Tumor (PEComa): Challenges and Solutions","volume":"15","author":"Czarnecka","year":"2023","journal-title":"Cancer Manag. 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