{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:55:11Z","timestamp":1760144111811,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>This is a retrospective study investigating biometric measurements using magnetic resonance imaging (MRI) examinations in congenital diaphragmatic hernia (CDH). CDH is one of the more common causes of pulmonary hypoplasia, with grave consequences for the fetus. Inclusion criteria were patients diagnosed with CDH as the only observed anomaly, who underwent MRI examination after the second-trimester morphology ultrasound. The patients came from three university hospitals in Bucharest, Romania. In total, 19 patients were included in the study after applying exclusion criteria. Comparing the observed values of the thoracic transverse diameter, the thoracic anterior\u2013posterior diameter, the thoracic circumference, the thoracic area, and the thoracic volume with values from the literature, we observed a predictive alteration of these parameters, with most showing Gaussian distribution. We observed statistical significance for most of our correlations, except between the observed and expected thoracic anterior\u2013posterior diameters and the observed and expected thoracic volume values. This is very helpful when complex studies that can calculate the pulmonary volume cannot be obtained, as in the case of movement artifacts, and allows the clinicians to better assess the severity of the disease. MRI follow-up in CDH cases is a necessity, as it offers the most accurate thoracic biometry.<\/jats:p>","DOI":"10.3390\/diagnostics14060641","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T10:54:38Z","timestamp":1710759278000},"page":"641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thoracic Biometry in Patients with Congenital Diaphragmatic Hernia, a Magnetic Resonance Imaging Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Erick George","family":"Ne\u0219tianu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 030167 Bucharest, Romania"},{"name":"H\u00f4pital Bic\u00eatre AP-HP, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Septimiu","family":"Popescu","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bic\u00eatre AP-HP, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"Faculty of Medicine, L\u2019Universit\u00e9 Paris-Saclay, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-8048","authenticated-orcid":false,"given":"Drago\u0219 Ovidiu","family":"Alexandru","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Bio-Statistics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Giurc\u0103neanu","sequence":"additional","affiliation":[{"name":"University Hospital of Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9512-2673","authenticated-orcid":false,"given":"Radu","family":"Vl\u0103d\u0103reanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 030167 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Elias University Emergency Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"ref_1","unstructured":"Tisekar, O.R., and Ak, A.K. (2021). Hypoplastic Lung Disease, StatPearls Publishing."},{"key":"ref_2","unstructured":"Weerakkody, Y. (2024, March 15). Pulmonary Hypoplasia|Radiology Reference Article|Radiopaedia.org. Available online: https:\/\/radiopaedia.org\/articles\/pulmonary-hypoplasia?lang=us."},{"key":"ref_3","unstructured":"(2024, March 15). The Fetal Medicine Foundation. Available online: https:\/\/fetalmedicine.org\/education\/fetal-abnormalities\/thorax\/lung-agenesis-hypoplasia."},{"key":"ref_4","unstructured":"Themes, U.F.O. (2019). Ultrasound Evaluation of the Fetal Thorax, Radiologykey."},{"key":"ref_5","unstructured":"Dumpa, V., and Chandrasekharan, P. (2021). Congenital Diaphragmatic Hernia, StatPearls."},{"key":"ref_6","unstructured":"Chakraborty, R.K., Modi, P., and Sharma, S. (2021). Pulmonary Sequestration, StatPearls."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Prayer, D. (2011). Fetal MRI, Springer.","DOI":"10.1007\/978-3-540-73271-6"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-016-2545-0","article-title":"Development of the lung","volume":"367","author":"Schittny","year":"2017","journal-title":"Cell Tissue Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0029-7844(95)00195-W","article-title":"Pulmonary hypoplasia: Pathogenesis, diagnosis, and antenatal prediction","volume":"86","author":"Lauria","year":"1995","journal-title":"Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100693","DOI":"10.1016\/j.ajogmf.2022.100693","article-title":"Assessment of the fetal lungs in utero","volume":"4","author":"Hutter","year":"2022","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/j.sempedsurg.2012.10.007","article-title":"Management of prenatally diagnosed congenital diaphragmatic hernia","volume":"22","author":"Hedrick","year":"2013","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/uog.39","article-title":"Three- dimensional ultrasound fetal lung volume measurement: A systematic study comparing the multiplanar method with the rotational (VOCAL) technique","volume":"21","author":"Kalache","year":"2003","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejrad.2005.11.031","article-title":"MRI of normal and pathological fetal lung development","volume":"57","author":"Kasprian","year":"2006","journal-title":"Eur. J. Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/uog.4052","article-title":"Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia","volume":"30","author":"Jani","year":"2007","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_15","unstructured":"Chin, T.W., and Kataria, N. (2024, March 16). Pediatric Pulmonary Hypoplasia Treatment Management: Medical Care, Surgical Care, Consultations. EMedicine 2023. Available online: https:\/\/emedicine.medscape.com\/article\/1005696-treatment?form=fpf."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sefidbakht, S., Dehdashtian, A., Bagheri, F., Rahimirad, N., Keshavarz, P., and Bijan, B. (2020). Standard Normal Fetal Lung Volume by MRI Measurement. Iran. J. Radiol., 17.","DOI":"10.5812\/iranjradiol.97847"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1148\/radiol.2313021689","article-title":"Quantitative and Qualitative Evaluations of Fetal Lung with MR Imaging","volume":"231","author":"Osada","year":"2004","journal-title":"Radiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1148\/radiology.219.1.r01ap18236","article-title":"Fetal Lung Volume: Estimation at MR Imaging\u2014Initial Results","volume":"219","author":"Rypens","year":"2001","journal-title":"Radiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.2214\/AJR.17.19469","article-title":"Fetal Lung Volumes by MRI: Normal Weekly Values From 18 Through 38 Weeks\u2019 Gestation","volume":"211","author":"Meyers","year":"2018","journal-title":"Am. J. Roentgenol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lian, X., Xu, Z., Zheng, L., Zhu, Z., Ejiwale, T., Kumar, A., Cai, P., He, S., Liu, S., and Zhang, Y. (2021). Reference range of fetal thorax using two-dimensional and three-dimensional ultrasound VOCAL technique and application in fetal thoracic malformations. BMC Med. Imaging, 21.","DOI":"10.1186\/s12880-021-00548-w"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cerbelle, V., Le Duc, K., Lejeune, S., Mur, S., Lerisson, H., Drumez, E., Sfeir, R., Bigot, J., Verpillat, P., and Boukhris, R. (2023). Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041508"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1080\/14767058.2019.1636029","article-title":"Imagiological methods for prediction of fetal pulmonary hypoplasia: A systematic review","volume":"34","year":"2021","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_23","first-page":"495","article-title":"Ultrasound prediction of pulmonary hypoplasia","volume":"68","author":"Nimrod","year":"1986","journal-title":"Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/0002-9378(88)90244-X","article-title":"Fetal thoracic circumference: A prospective cross-sectional study with real-time ultrasound","volume":"158","author":"Fong","year":"1988","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0002-9378(87)90112-8","article-title":"Prenatal sonographic assessment of the fetal thorax: Normal values","volume":"156","author":"Chitkara","year":"1987","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/0002-9378(89)90363-3","article-title":"Comparison of six different ultrasonographic methods for predicting lethal fetal pulmonary hypoplasia","volume":"161","author":"Vintzileos","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1046\/j.1469-0705.2000.00252.x","article-title":"The fetal lung 2: Pulmonary hypoplasia","volume":"16","author":"Laudy","year":"2000","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0002-9378(96)70165-5","article-title":"Ultrasonographic prediction of lethal pulmonary hypoplasia: Comparison of eight different ultrasonographic parameters","volume":"175","author":"Yoshimura","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/AOG.0b013e31823d3aea","article-title":"Fetal Pulmonary Response After Fe- toscopic Tracheal Occlusion for Severe Isolated Congenital Diaphragmatic Hernia","volume":"119","author":"Ruano","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/uog.20296","article-title":"Three-dimensional reconstruction of defects in congenital diaphragmatic hernia: A fetal MRI study","volume":"53","author":"Prayer","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s10397-018-1041-9","article-title":"Fetoscopic endoluminal tracheal occlusion and reestablishment of fetal airways for congenital diaphragmatic hernia","volume":"15","author":"Russo","year":"2018","journal-title":"Gynecol. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.21037\/tp-20-130","article-title":"Fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia: A narrative review of the history, current practice, and future directions","volume":"10","author":"Perrone","year":"2021","journal-title":"Transl. Pediatr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0022-3468(97)90472-3","article-title":"Correction of congenital diaphragmatic hernia in utero VII: A prospective trial","volume":"32","author":"Harrison","year":"1997","journal-title":"J. Pediatr. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/uog.22182","article-title":"Prenatal treatment of severe congenital diaphragmatic hernia: There is still medical equipoise","volume":"56","author":"Deprest","year":"2020","journal-title":"Ultrasound Obstet. 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