{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:27:21Z","timestamp":1790288841717,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lucian Blaga University of Sibiu","award":["LBUS-HPI-ERG-2023-05"],"award-info":[{"award-number":["LBUS-HPI-ERG-2023-05"]}]},{"name":"Lucian Blaga University of Sibiu","award":["28PFE\/30.12.2021"],"award-info":[{"award-number":["28PFE\/30.12.2021"]}]},{"name":"the Ministry of Research, Innovation and Digitization","award":["LBUS-HPI-ERG-2023-05"],"award-info":[{"award-number":["LBUS-HPI-ERG-2023-05"]}]},{"name":"the Ministry of Research, Innovation and Digitization","award":["28PFE\/30.12.2021"],"award-info":[{"award-number":["28PFE\/30.12.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Gastric duplication cysts (GDCs) in adults are exceedingly rare, with only a few documented cases in medical literature. The spectrum of clinical presentations varies widely, ranging from asymptomatic to severe symptoms such as hematemesis, vomiting or abdominal pain. Among the less common complications associated with GDCs, segmental portal hypertension is a notable rarity. We present a compelling case report of a patient exhibiting signs of segmental portal hypertension, where ultrasound and echo-endoscopy revealed a sizable gastric duplication cyst as the underlying etiology. Recognizing the scarcity of literature on GDCs in adult patients, we conducted a thorough review to underscore the diagnostic significance of ultrasonography and endoscopic ultrasound (EUS) in accurately identifying these congenital anomalies. This case report and comprehensive literature review emphasize the pivotal role of EUS and abdominal ultrasound in achieving an accurate diagnosis of GDCs. By shedding light on the diagnostic and therapeutic intricacies, we aim to raise awareness among clinicians regarding this rare pathology and the importance of multimodal imaging approaches for optimal patient management.<\/jats:p>","DOI":"10.3390\/diagnostics14070675","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:00:23Z","timestamp":1711375223000},"page":"675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Uncommon Presentation of Gastric Duplication Cyst with Left-Sided Portal Hypertension: A Case Report and Literature Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-1585","authenticated-orcid":false,"given":"Adrian","family":"Boicean","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Prisca","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-6293","authenticated-orcid":false,"given":"Dan Georgian","family":"Bratu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-7591","authenticated-orcid":false,"given":"Ciprian Ionut","family":"Bacila","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Tanasescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-4475","authenticated-orcid":false,"given":"Radu","family":"Chicea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-9828","authenticated-orcid":false,"given":"Sorin Radu","family":"Fleaca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7368-7674","authenticated-orcid":false,"given":"Sabrina Andreea","family":"Birsan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Ichim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calin Ilie","family":"Mohor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-8515","authenticated-orcid":false,"given":"Mihai Dan","family":"Roman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Nicolae","family":"Cristian","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Bogdan","family":"Todor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmin Ioan","family":"Mohor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Moisin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-0562","authenticated-orcid":false,"given":"Adrian","family":"Hasegan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, 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Rare Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e13005","DOI":"10.1097\/MD.0000000000013005","article-title":"A Huge Completely Isolated Duplication Cyst Complicated by Torsion and Lined by 3 Different Mucosal Epithelial Components in an Adult: A Case Report","volume":"97","author":"Ai","year":"2018","journal-title":"Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101470","DOI":"10.1016\/j.epsc.2020.101470","article-title":"Acute Inflammation of Gastric Duplication Cyst in a Toddler","volume":"58","author":"Alghamdi","year":"2020","journal-title":"J. Pediatr. Surg. Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.clinimag.2015.11.016","article-title":"Complete Gastric Duplication in an Adult with Associated Anomalies","volume":"40","author":"Bhatti","year":"2016","journal-title":"Clin. 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StatPearls, StatPearls Publishing."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s40792-021-01337-x","article-title":"An Adult Case of a Retroperitoneal Isolated Enteric Duplication Cyst with the Imaging Changes over Time","volume":"7","author":"Inomata","year":"2021","journal-title":"Surg. Case Rep."},{"key":"ref_10","first-page":"605059","article-title":"Gastric Duplication Cyst: Two Case Reports and Review of the Literature","volume":"2013","author":"Singh","year":"2013","journal-title":"Case Rep. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7905","DOI":"10.12998\/wjcc.v11.i32.7905","article-title":"New Treatment for Gastric Duplication Cyst: Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Combined with Lauromacrogol Sclerotherapy: A Case Report","volume":"11","author":"Bu","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"ref_12","first-page":"e19560","article-title":"Gastric Duplication Cyst Revealed After an Endoscopic Ultrasound-Guided Fine-Needle Aspiration of a Suspected Mucinous Cystadenoma of the Pancreas","volume":"13","author":"Cherouaqi","year":"2021","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0016-5107(98)70304-9","article-title":"Use of Endoscopic Ultrasound to Guide the Diagnosis and Endoscopic Management of a Large Gastric Duplication Cyst","volume":"47","author":"Woolfolk","year":"1998","journal-title":"Gastrointest. Endosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"rjw073","DOI":"10.1093\/jscr\/rjw073","article-title":"Gastric Duplication Cyst: A Rare Entity","volume":"2016","author":"Doepker","year":"2016","journal-title":"J. Surg. Case Rep."},{"key":"ref_15","unstructured":"Glick, Y., and Teixeira, A. (2024, February 11). Gastric Duplication Cyst. Available online: https:\/\/radiopaedia.org\/articles\/19579."},{"key":"ref_16","first-page":"188","article-title":"Pancreatic Cystic Lesions. Differential Diagnosis and Treatment Strategy","volume":"87","year":"2022","journal-title":"Rev. Gastroenterol. M\u00e9xico (Engl. Ed.)"},{"key":"ref_17","first-page":"340","article-title":"The Clinical Utility of CA 19-9 in Pancreatic Adenocarcinoma: Diagnostic and Prognostic Updates","volume":"13","author":"Poruk","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3941\/jrcr.v11i8.3124","article-title":"Complicated Gastric Duplication Cyst in an Adult Patient: Uncommon Presentation of an Uncommon Disease","volume":"11","author":"Abdalkader","year":"2017","journal-title":"Radiol. Case"},{"key":"ref_19","first-page":"367","article-title":"Adenocarcinoma Arising from a Gastric Duplication Cyst: A Case Report and Literature Review","volume":"10","author":"Abdulla","year":"2017","journal-title":"Int. Med. Case Rep. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/0972-9941.181772","article-title":"Gastric Duplication Cyst in Adult: Challenge for Surgeons","volume":"13","author":"Namdaroglu","year":"2017","journal-title":"J. Min. Access Surg."},{"key":"ref_21","unstructured":"Hassan, H.S., Elhady, H.A., and Elfarargy, M.S. (2024, February 11). Gastric Duplication Cyst Mimicking a Liver Cyst Case Report and Review of the Literature. Available online: https:\/\/pjmhsonline.com\/2020\/oct_dec\/1417.pdf."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"88E","DOI":"10.1308\/003588414X13824511649977","article-title":"Gastric Duplication Cyst Masquerading as a Mucinous Pancreatic Cyst: Case Report and Literature Review","volume":"96","author":"Bailey","year":"2014","journal-title":"Annals"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/eus.eus_52_20","article-title":"Malignant Gastric Duplication Cyst Diagnosed by EUS-FNA","volume":"10","author":"Togliani","year":"2021","journal-title":"Endosc. Ultrasound"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/000313480807400122","article-title":"Gastric Duplication Cysts Expressing Carcinoembryonic Antigen Mimicking Cystic Pancreatic Neoplasms in Two Adults","volume":"74","author":"Johnston","year":"2008","journal-title":"Am. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mardi, K., Kaushal, V., and Gupta, S. (2010). Foregut Duplication Cysts of Stomach Masquerading as Leiomyoma. Indian J. Pathol. Microbiol., 53.","DOI":"10.4103\/0377-4929.59214"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.12998\/wjcc.v7.i22.3866","article-title":"Diagnosis of Gastric Duplication Cyst by Positron Emission Tomography\/Computed Tomography: A Case Report","volume":"7","author":"Hu","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.gie.2007.10.057","article-title":"Demonstration of Peristalsis in Gastric Duplication Cyst by EUS: Implications for Diagnosis and Symptomatology (with Videos)","volume":"68","author":"Bhatia","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"ref_28","first-page":"586","article-title":"Quiste de Duplicaci\u00f3n G\u00e1strico: Diagn\u00f3stico Por Punci\u00f3n-Aspiraci\u00f3n Guiada Por Ecoendoscopia","volume":"100","year":"2008","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mizuide, M., Ryozawa, S., Fujita, A., Ogawa, T., Katsuda, H., Suzuki, M., Noguchi, T., and Tanisaka, Y. (2020). Complications of Endoscopic Ultrasound-Guided Fine Needle Aspiration: A Narrative Review. Diagnostics, 10.","DOI":"10.3390\/diagnostics10110964"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tgie.2005.10.006","article-title":"Complications of EUS-FNA","volume":"7","author":"Faulx","year":"2005","journal-title":"Tech. Gastrointest. Endosc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02013165","article-title":"Enteric Duplication Cysts in Children: Are Their Ultrasonographic Wall Characteristics Diagnostic?","volume":"20","author":"Barr","year":"1990","journal-title":"Pediatr. Radiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/0016-5085(95)90392-5","article-title":"Diagnosis of Foregut Duplication Cysts by Endoscopic Ultrasonography","volume":"109","author":"Geller","year":"1995","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13256-019-2129-1","article-title":"Successful Laparoscopic Resection for Gastric Duplication Cyst: A Case Report","volume":"13","author":"Izumi","year":"2019","journal-title":"J. Med. Case Rep."},{"key":"ref_34","first-page":"785","article-title":"Gastric Duplication Cyst Lined by Pseudostratified Columnar Ciliated Epithelium Masquerading as a Pancreatic Mucinous Cystic Neoplasm: A Case Report and Literature Review","volume":"13","author":"Zhan","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"857056","DOI":"10.3389\/fped.2022.857056","article-title":"Clinical Characteristics of Gastric Duplication in Children","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e14820","DOI":"10.1097\/MD.0000000000014820","article-title":"Removal of an Infant\u2019s Gastric Duplication Cyst through Endoscopic Submucosal Dissection: A Case Report","volume":"98","author":"Fang","year":"2019","journal-title":"Medicine"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/7\/675\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:18:18Z","timestamp":1760105898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/7\/675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["diagnostics14070675"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14070675","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]}}}