{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:02:21Z","timestamp":1791234141975,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Despite the increasing number of ICU admissions among patients with solid tumours, there is a lack of tools with which to identify patients who may benefit from critical support. We aim to characterize the clinical profile and outcomes of patients with solid malignancies admitted to the ICU. Methods: Retrospective observational study of patients with cancer non-electively admitted to the ICU of the Hospital Clinic of Barcelona (Spain) between January 2019 and December 2019. Data regarding patient and neoplasm characteristics, ICU admission features and outcomes were collected from medical records. Results: 97 ICU admissions of 84 patients were analysed. Lung cancer (22.6%) was the most frequent neoplasm. Most of the patients had metastatic disease (79.5%) and were receiving oncological treatment (75%). The main reason for ICU admission was respiratory failure (38%). Intra-ICU and in-hospital mortality rates were 9.4% and 24%, respectively. Mortality rates at 1, 3 and 6 months were 19.6%, 36.1% and 53.6%. Liver metastasis, gastrointestinal cancer, hypoalbuminemia, elevated basal C-reactive protein, ECOG-PS greater than 2 at ICU admission, admission from ward and an APACHE II score over 14 were related to higher mortality. Functional status was severely affected at discharge, and oncological treatment was definitively discontinued in 40% of the patients. Conclusion: Medium-term mortality and functional deterioration of patients with solid cancers non-electively admitted to the ICU are high. Surrogate markers of cachexia, liver metastasis and poor ECOG-PS at ICU admission are risk factors for mortality.<\/jats:p>","DOI":"10.3390\/diagnostics14070730","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T06:33:16Z","timestamp":1711693996000},"page":"730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Characterisation and Outcomes of Patients with Solid Organ Malignancies Admitted to the Intensive Care Unit: Mortality and Impact on Functional Status and Oncological Treatment"],"prefix":"10.3390","volume":"14","author":[{"given":"Marta","family":"Garc\u00eda de Herreros","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Translational Genomics and Targeted Therapies in Solid Tumors, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-1186","authenticated-orcid":false,"given":"Juan Carlos","family":"Laguna","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Translational Genomics and Targeted Therapies in Solid Tumors, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-5811","authenticated-orcid":false,"given":"Joan","family":"Padrosa","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Medical Intensive Care Unit, Internal Medicine Department Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanny Daniela","family":"Barreto","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoli","family":"Chicote","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Font","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Translational Genomics and Targeted Therapies in Solid Tumors, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Grafi\u00e1","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Medical Intensive Care Unit, Internal Medicine Department Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Llavata","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-9825","authenticated-orcid":false,"given":"Elia","family":"Segu\u00ed","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Translational Genomics and Targeted Therapies in Solid Tumors, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-5856","authenticated-orcid":false,"given":"Albert","family":"Tuca","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Translational Genomics and Targeted Therapies in Solid Tumors, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Viladot","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Translational Genomics and Targeted Therapies in Solid Tumors, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-0809","authenticated-orcid":false,"given":"Carles","family":"Zamora-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Medical Intensive Care Unit, Internal Medicine Department Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fern\u00e1ndez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Internal Medicine Department Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"T\u00e9llez","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Internal Medicine Department Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Maria","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Internal Medicine Department Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-540X","authenticated-orcid":false,"given":"Aleix","family":"Prat","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic de Barcelona, C\/Villarroel 170, 08036 Barcelona, Spain"},{"name":"Translational Genomics and Targeted Therapies in Solid Tumors, Institut d\u2019Investigacions 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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