{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:17:45Z","timestamp":1770747465149,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The aim of this study is to assess the effectiveness of a 12-week doxycycline treatment for thyroid eye disease (TED), an autoimmune condition associated with thyroid dysfunction. In this randomized controlled clinical trial, 82 patients were randomly assigned at a 1:1 ratio to receive doxycycline (50 mg) or to undergo no treatment. Various metrics, including margin reflex distance (MRD1 and MRD2), eyelid aperture, levator muscle function, lagophthalmos, proptosis, ocular motility, diplopia, and Graves\u2019 ophthalmopathy-specific quality-of-life (GO-QOL) scale scoring were assessed. Exclusion criteria were uncontrolled systemic diseases, tetracycline allergies, pregnancy, lactation, or age below 18. The mean age was 51.6 years (SD), 87.8% of participants were female, and all were Caucasians. By week 12, the doxycycline group exhibited a significant improvement rate based on MRD2 (from 4 to 15 participants with physiological findings), clinical activity score (from 7 to 35 participants with non-active disease), and GO-QOL (from 51.22% to 70.73% of participants with a good life quality). Doxycycline showcased anti-inflammatory and immunomodulatory effects in treating TED, suggesting its potential efficacy for TED and other orbit inflammatory conditions. However, these results warrant further validation through future research involving extended follow-up periods and larger cohorts.<\/jats:p>","DOI":"10.3390\/diagnostics14080791","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:07:46Z","timestamp":1712729266000},"page":"791","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["One Incremental Stride for Doxycycline, One Substantial Advancement for Thyroid Eye Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Ines","family":"Matoc","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Kasa","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Kasumovi\u0107","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ante","family":"Prpi\u0107","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ante","family":"Vukojevi\u0107","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ognjen","family":"Zrin\u0161\u0107ak","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"\u0160kunca Herman","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka","family":"Doko Mandi\u0107","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-8528","authenticated-orcid":false,"given":"Ivan","family":"Sabol","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Ru\u0111er Bo\u0161kovi\u0107 Institute (RBI), 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Ivekovi\u0107","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Vatavuk","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Sestre milosrdnice Zagreb UHC, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"b560","DOI":"10.1136\/bmj.b560","article-title":"Thyroid eye disease","volume":"338","author":"Perros","year":"2009","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1056\/NEJMra0905750","article-title":"Graves\u2019 ophthalmopathy","volume":"362","author":"Bahn","year":"2010","journal-title":"N. 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