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This innovative procedure entails transferring gut microbiota from healthy donors to individuals affected by pancreatic ailments with the potential to restore intestinal balance and alleviate associated symptoms. FMT represents a pioneering approach to improve patient outcomes in pancreatic diseases, offering tailored treatments customized to individual microbiomes and specific conditions. Recent research highlights the therapeutic benefits of targeting the gut microbiota for personalized interventions in pancreatic disorders. However, a comprehensive understanding of the intricate interplay between gut microbiota and pancreatic physiology warrants further investigation. 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(2023). The Gut\u2013Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24044089"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cgh.2018.08.045","article-title":"The Gut Microbiome in Pancreatic Disease","volume":"17","author":"Akshintala","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Yang, Q., Zhang, J., and Zhu, Y. (2022). Potential Roles of the Gut Microbiota in Pancreatic Carcinogenesis and Therapeutics. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.872019"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41598-022-05127-9","article-title":"Health Improvements of Type 2 Diabetic Patients through Diet and Diet plus Fecal Microbiota Transplantation","volume":"12","author":"Su","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5946\/ce.2019.009","article-title":"Fecal Microbiota Transplantation: An Update on Clinical Practice","volume":"52","author":"Kim","year":"2019","journal-title":"Clin. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.jfma.2018.08.011","article-title":"Fecal Microbiota Transplantation: Review and Update","volume":"118","author":"Wang","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nrgastro.2016.98","article-title":"Understanding the Mechanisms of Faecal Microbiota Transplantation","volume":"13","author":"Khoruts","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cca.2019.12.010","article-title":"Fecal Microbiota Transplantation in Disease Therapy","volume":"503","author":"Antushevich","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3343\/alm.2021.41.4.424","article-title":"Laboratory Aspects of Donor Screening for Fecal Microbiota Transplantation at a Korean Fecal Microbiota Bank","volume":"41","author":"Seo","year":"2021","journal-title":"Ann. Lab. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.eimc.2020.09.002","article-title":"Recommendations for Stool Donor Selection for Fecal Microbiota Transplant. Consensus Document Endorsed by the Catalan Society of Digestology, Catalan Society of Infectious Diseases and Clinical Microbiology and the GEMBIOTA Group from Spanish Society of Infectious Diseases and Clinical Microbiology","volume":"40","author":"Aira","year":"2022","journal-title":"Enfermedades Infecc. Microbiol. Clin. Engl. Ed."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"B\u00e9nard, M.V., De Bruijn, C.M.A., Fenneman, A.C., Wortelboer, K., Zeevenhoven, J., Rethans, B., Herrema, H.J., Van Gool, T., Nieuwdorp, M., and Benninga, M.A. (2022). Challenges and Costs of Donor Screening for Fecal Microbiota Transplantations. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0276323"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1136\/gutjnl-2019-319548","article-title":"International Consensus Conference on Stool Banking for Faecal Microbiota Transplantation in Clinical Practice","volume":"68","author":"Cammarota","year":"2019","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Boicean, A., Birlutiu, V., Ichim, C., Anderco, P., and Birsan, S. (2023). Fecal Microbiota Transplantation in Inflammatory Bowel Disease. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041016"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103033","DOI":"10.1016\/j.jaut.2023.103033","article-title":"Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Patients with Concurrent Ulcerative Colitis","volume":"141","author":"Porcari","year":"2023","journal-title":"J. Autoimmun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41575-019-0242-7","article-title":"Microbiota in Pancreatic Health and Disease: The next Frontier in Microbiome Research","volume":"17","author":"Thomas","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/carcin\/bgy073","article-title":"Intestinal Microbiota Enhances Pancreatic Carcinogenesis in Preclinical Models","volume":"39","author":"Thomas","year":"2018","journal-title":"Carcinogenesis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.immuni.2015.07.013","article-title":"Pancreatic \u03b2-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota","volume":"43","author":"Sun","year":"2015","journal-title":"Immunity"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"95176","DOI":"10.18632\/oncotarget.18820","article-title":"Gut Microbial Profile Analysis by MiSeq Sequencing of Pancreatic Carcinoma Patients in China","volume":"8","author":"Ren","year":"2017","journal-title":"Oncotarget"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/gutjnl-2021-324755","article-title":"A Faecal Microbiota Signature with High Specificity for Pancreatic Cancer","volume":"71","author":"Kartal","year":"2022","journal-title":"Gut"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2019.07.008","article-title":"Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes","volume":"178","author":"Riquelme","year":"2019","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lu, H., Ren, Z., Li, A., Li, J., Xu, S., Zhang, H., Jiang, J., Yang, J., Luo, Q., and Zhou, K. (2019). Tongue Coating Microbiome Data Distinguish Patients with Pancreatic Head Cancer from Healthy Controls. J. Oral Microbiol., 11.","DOI":"10.1080\/20002297.2018.1563409"},{"key":"ref_22","first-page":"485","article-title":"Gut Microbiota Predicts Severity and Reveals Novel Metabolic Signatures in Acute Pancreatitis","volume":"73","author":"Antweiler","year":"2023","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Boicean, A., Birlutiu, V., Ichim, C., Brusnic, O., and Oni\u0219or, D.M. (2023). Fecal Microbiota Transplantation in Liver Cirrhosis. Biomedicines, 11.","DOI":"10.3390\/biomedicines11112930"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-1-4939-6361-4_19","article-title":"A Practical Method for Preparation of Fecal Microbiota Transplantation","volume":"Volume 1476","author":"Roberts","year":"2016","journal-title":"Clostridium difficile"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"104954","DOI":"10.1016\/j.phrs.2020.104954","article-title":"Delivery Routes for Faecal Microbiota Transplants: Available, Anticipated and Aspired","volume":"159","author":"Gulati","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41396-018-0301-z","article-title":"Effect of Fecal Microbiota Transplantation Route of Administration on Gut Colonization and Host Response in Preterm Pigs","volume":"13","author":"Brunse","year":"2019","journal-title":"ISME J."},{"key":"ref_27","first-page":"27657","article-title":"Feces Transplantation for Recurrent Clostridium difficile Infection: US Experience and Recommendations","volume":"26","author":"Bakken","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1073\/pnas.1102938108","article-title":"Extensive Personal Human Gut Microbiota Culture Collections Characterized and Manipulated in Gnotobiotic Mice","volume":"108","author":"Goodman","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1038\/s41598-023-29637-2","article-title":"Effect of in Vitro Cultivation on Human Gut Microbiota Composition Using 16S RDNA Amplicon Sequencing and Metabolomics Approach","volume":"13","author":"Roszko","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.radonc.2020.01.011","article-title":"Fecal Microbiota Transplantation: A Promising Treatment for Radiation Enteritis?","volume":"143","author":"Ding","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40164-023-00410-5","article-title":"The Gut Microbiota as a Booster for Radiotherapy: Novel Insights into Radio-Protection and Radiation Injury","volume":"12","author":"Yi","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwad044","article-title":"Radiation Injury and Gut Microbiota-Based Treatment","volume":"15","author":"Wang","year":"2024","journal-title":"Protein Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13014-020-01735-9","article-title":"Radiotherapy and the Gut Microbiome: Facts and Fiction","volume":"16","author":"Liu","year":"2021","journal-title":"Radiat. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"448","DOI":"10.15252\/emmm.201606932","article-title":"Faecal Microbiota Transplantation Protects against Radiation-induced Toxicity","volume":"9","author":"Cui","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-023-01406-7","article-title":"Role of the Gut Microbiota in Anticancer Therapy: From Molecular Mechanisms to Clinical Applications","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1983101","DOI":"10.1080\/19490976.2021.1983101","article-title":"Isolation of Pancreatic Microbiota from Cystic Precursors of Pancreatic Cancer with Intracellular Growth and DNA Damaging Properties","volume":"13","author":"Halimi","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7946431","DOI":"10.1155\/2018\/7946431","article-title":"Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders","volume":"2018","author":"Pagliari","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/eji.202149532","article-title":"Intestinal Homeostasis and Inflammation: Gut Microbiota at the Crossroads of Pancreas\u2013Intestinal Barrier Axis","volume":"52","author":"Zhang","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.immuni.2015.08.003","article-title":"Gut-Pancreatic Axis AMPlified in Islets of Langerhans","volume":"43","author":"Ryu","year":"2015","journal-title":"Immunity"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.3748\/wjg.v28.i33.4762","article-title":"Immunological Mechanisms of Fecal Microbiota Transplantation in Recurrent Clostridioides difficile Infection","volume":"28","author":"Soveral","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"105803","DOI":"10.1016\/j.micpath.2022.105803","article-title":"Fecal Microbiota Transplantation Improves Intestinal Inflammation in Mice with Ulcerative Colitis by Modulating Intestinal Flora Composition and Down-Regulating NF-KB Signaling Pathway","volume":"173","author":"Li","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1038\/s41467-018-07359-8","article-title":"Therapeutic Faecal Microbiota Transplantation Controls Intestinal Inflammation through IL10 Secretion by Immune Cells","volume":"9","author":"Burrello","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Li, M., Yang, H., Shao, C., Liu, Y., Wen, S., and Tang, L. (2023). Application of Dominant Gut Microbiota Promises to Replace Fecal Microbiota Transplantation as a New Treatment for Alzheimer\u2019s Disease. Microorganisms, 11.","DOI":"10.3390\/microorganisms11122854"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G., Gasbarrini, A., and Mele, M. (2019). What Is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 7.","DOI":"10.3390\/microorganisms7010014"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2021.09.061","article-title":"Transferable Immunoglobulin A\u2013Coated Odoribacter Splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation","volume":"162","author":"Lima","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Yang, C., Hu, T., Xue, X., Su, X., Zhang, X., Fan, Y., Shen, X., and Dong, X. (2023). Multi-Omics Analysis of Fecal Microbiota Transplantation\u2019s Impact on Functional Constipation and Comorbid Depression and Anxiety. BMC Microbiol., 23.","DOI":"10.1186\/s12866-023-03123-1"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/s41564-021-00966-0","article-title":"Precise Quantification of Bacterial Strains after Fecal Microbiota Transplantation Delineates Long-Term Engraftment and Explains Outcomes","volume":"6","author":"Aggarwala","year":"2021","journal-title":"Nat. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lee, S.T.M., Kahn, S.A., Delmont, T.O., Shaiber, A., Esen, \u00d6.C., Hubert, N.A., Morrison, H.G., Antonopoulos, D.A., Rubin, D.T., and Eren, A.M. (2017). Tracking Microbial Colonization in Fecal Microbiota Transplantation Experiments via Genome-Resolved Metagenomics. Microbiome, 5.","DOI":"10.1186\/s40168-017-0270-x"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"773105","DOI":"10.3389\/fmed.2022.773105","article-title":"Features of Gut Microbiome Associated with Responses to Fecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"814269","DOI":"10.3389\/fnut.2022.814269","article-title":"Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer Statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Li, Q., Jin, M., Liu, Y., and Jin, L. (2020). Gut Microbiota: Its Potential Roles in Pancreatic Cancer. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.572492"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ijc.32003","article-title":"Fecal Microbiota Transplantation in Cancer Management: Current Status and Perspectives","volume":"145","author":"Chen","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/PPO.0000000000000651","article-title":"Fecal Microbiota Transplantation as a Cancer Therapeutic","volume":"29","author":"Stoff","year":"2023","journal-title":"Cancer J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1047-2797(02)00425-8","article-title":"An Exploration of the Periodontitis\u2013Cancer Association","volume":"13","author":"Hujoel","year":"2003","journal-title":"Ann. Epidemiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/gutjnl-2011-300784","article-title":"Variations of Oral Microbiota Are Associated with Pancreatic Diseases Including Pancreatic Cancer","volume":"61","author":"Farrell","year":"2012","journal-title":"Gut"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","article-title":"The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression","volume":"8","author":"Pushalkar","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_58","first-page":"420","article-title":"Fecal Microbiota Transplantation: Past, Present and Future Perspectives","volume":"63","author":"Ianiro","year":"2017","journal-title":"Minerva Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1158\/1055-9965.EPI-18-0542","article-title":"The Microbiomes of Pancreatic and Duodenum Tissue Overlap and Are Highly Subject Specific but Differ between Pancreatic Cancer and Noncancer Subjects","volume":"28","author":"Meier","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.18632\/oncotarget.3109","article-title":"Association of Fusobacterium Species in Pancreatic Cancer Tissues with Molecular Features and Prognosis","volume":"6","author":"Mitsuhashi","year":"2015","journal-title":"Oncotarget"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.3748\/wjg.v26.i18.2187","article-title":"Role of Gut Microbiota on Intestinal Barrier Function in Acute Pancreatitis","volume":"26","author":"Li","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s40265-022-01766-4","article-title":"Acute Pancreatitis: Diagnosis and Treatment","volume":"82","author":"Szatmary","year":"2022","journal-title":"Drugs"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Boicean, A., Birlutiu, V., Ichim, C., Todor, S.B., Hasegan, A., Bacila, C., Solomon, A., Cristian, A., and Dura, H. (2023). Predictors of Post-ERCP Pancreatitis (P.E.P.) in Choledochal Lithiasis Extraction. J. Pers. Med., 13.","DOI":"10.3390\/jpm13091356"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Yan, X., Li, J., and Wu, D. (2023). The Role of Short-Chain Fatty Acids in Acute Pancreatitis. Molecules, 28.","DOI":"10.3390\/molecules28134985"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.3748\/wjg.v27.i30.5019","article-title":"Gut Microbiome in Acute Pancreatitis: A Review Based on Current Literature","volume":"27","author":"Patel","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Mei, Q., Fu, Y., and Zeng, Y. (2021). Alteration of Gut Microbiota in Acute Pancreatitis and Associated Therapeutic Strategies. Biomed. Pharmacother., 141.","DOI":"10.1016\/j.biopha.2021.111850"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pan.2020.12.013","article-title":"Microbiome Changes Associated with Acute and Chronic Pancreatitis: A Systematic Review","volume":"21","author":"Brubaker","year":"2021","journal-title":"Pancreatology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"17562848231202132","DOI":"10.1177\/17562848231202133","article-title":"Gut Microbiota Interacts with Inflammatory Responses in Acute Pancreatitis","volume":"16","author":"Wu","year":"2023","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1017\/S0007114509990213","article-title":"Comparative Effect of Orally Administered Sodium Butyrate before or after Weaning on Growth and Several Indices of Gastrointestinal Biology of Piglets","volume":"102","author":"Gallois","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00535-018-1529-0","article-title":"Gut Microbiota Dysbiosis Worsens the Severity of Acute Pancreatitis in Patients and Mice","volume":"54","author":"Zhu","year":"2019","journal-title":"J. Gastroenterol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/MPA.0000000000000355","article-title":"Dysbiosis of Intestinal Microbiota Associated With Inflammation Involved in the Progression of Acute Pancreatitis","volume":"44","author":"Tan","year":"2015","journal-title":"Pancreas"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.12998\/wjcc.v7.i17.2597","article-title":"Fecal Microbiota Transplantation as an Effective Initial Therapy for Pancreatitis Complicated with Severe Clostridium difficile Infection: A Case Report","volume":"7","author":"Hu","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1055\/a-0822-0832","article-title":"Endoscopic Treatment of Chronic Pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline\u2013Updated August 2018","volume":"51","author":"Dumonceau","year":"2019","journal-title":"Endoscopy"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Gesualdo, M., Rizzi, F., Bonetto, S., Rizza, S., Cravero, F., Saracco, G.M., and De Angelis, C.G. (2020). Pancreatic Diseases and Microbiota: A Literature Review and Future Perspectives. J. Clin. Med., 9.","DOI":"10.3390\/jcm9113535"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1017\/S0029665117001045","article-title":"Negotiating the Complexities of Exocrine and Endocrine Dysfunction in Chronic Pancreatitis","volume":"76","author":"Duggan","year":"2017","journal-title":"Proc. Nutr. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1016\/j.apsb.2023.08.002","article-title":"Gut Microbiota Controls the Development of Chronic Pancreatitis: A Critical Role of Short-Chain Fatty Acids-Producing Gram-Positive Bacteria","volume":"13","author":"Pan","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/MPA.0000000000000131","article-title":"Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life","volume":"43","author":"Ceyhan","year":"2014","journal-title":"Pancreas"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1097\/MPA.0000000000002273","article-title":"Real-World Patient Experience with Pancreatic Enzyme Replacement Therapy in the Treatment of Exocrine Pancreatic Insufficiency","volume":"53","author":"Barkin","year":"2024","journal-title":"Pancreas"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bbrc.2017.10.130","article-title":"Supplementation of Pancreatic Digestive Enzymes Alters the Composition of Intestinal Microbiota in Mice","volume":"495","author":"Nishiyama","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clnesp.2017.01.005","article-title":"Effects of Using Symbiotics in the Clinical Nutritional Evolution of Patients with Chronic Pancreatitis: Study Prospective, Randomized, Controlled, Double Blind","volume":"18","author":"Guedes","year":"2017","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"930872","DOI":"10.3389\/fimmu.2022.930872","article-title":"Fecal Microbiota Transplantation Treatment of Autoimmune-Mediated Type 1 Diabetes Mellitus","volume":"13","author":"He","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_82","first-page":"36","article-title":"Fecal Microbiota Transplantation for The Early-Onset Type 1 Diabetes. Could It Be a Promising Solution?","volume":"2","author":"Kasti","year":"2022","journal-title":"Kompass Nutr. Diet."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"101544","DOI":"10.1016\/j.beem.2021.101544","article-title":"Auto-Immunity and the Gut Microbiome in Type 1 Diabetes: Lessons from Rodent and Human Studies","volume":"35","author":"Nieuwdorp","year":"2021","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41586-018-0620-2","article-title":"The Human Gut Microbiome in Early-Onset Type 1 Diabetes from the TEDDY Study","volume":"562","author":"Vatanen","year":"2018","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e3043","DOI":"10.1002\/dmrr.3043","article-title":"Gut Microbiome in Type 1 Diabetes: A Comprehensive Review","volume":"34","author":"Zheng","year":"2018","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11892-017-0933-9","article-title":"Modulation of Type 1 Diabetes Risk by the Intestinal Microbiome","volume":"17","author":"Knip","year":"2017","journal-title":"Curr. Diab. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.21037\/tcr-21-2803","article-title":"The Relationship between Helicobacter Pylori and Pancreatic Cancer: A Meta-Analysis","volume":"11","author":"Xu","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Kouzu, K., Tsujimoto, H., Kishi, Y., Ueno, H., and Shinomiya, N. (2022). Bacterial Translocation in Gastrointestinal Cancers and Cancer Treatment. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020380"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Merali, N., Chouari, T., Kayani, K., Rayner, C.J., Jim\u00e9nez, J.I., Krell, J., Giovannetti, E., Bagwan, I., Relph, K., and Rockall, T.A. (2022). A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma. Cancers, 14.","DOI":"10.3390\/cancers14041020"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Zhang, C., Li, G., Lu, T., Liu, L., Sui, Y., Bai, R., Li, L., and Sun, B. (2023). The Interaction of Microbiome and Pancreas in Acute Pancreatitis. Biomolecules, 14.","DOI":"10.3390\/biom14010059"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/bph.15980","article-title":"Gut Microbiota-derived Nicotinamide Mononucleotide Alleviates Acute Pancreatitis by Activating Pancreatic SIRT3 Signalling","volume":"180","author":"Liu","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"772454","DOI":"10.3389\/fmed.2021.772454","article-title":"Efficacy and Safety of Faecal Microbiota Transplantation for Acute Pancreatitis: A Randomised, Controlled Study","volume":"8","author":"Ding","year":"2022","journal-title":"Front. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"574533","DOI":"10.3389\/fphar.2020.574533","article-title":"Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease: An Update","volume":"11","author":"Tan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Chechushkov, A., Desyukevich, P., Yakovlev, T., Al Allaf, L., Shrainer, E., Morozov, V., and Tikunova, N. (2024). Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031886"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"9217219","DOI":"10.1155\/2020\/9217219","article-title":"Saikosaponin A-Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1\/Nrf2-ARE Antioxidant Signaling","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/gutjnl-2020-322630","article-title":"Faecal Microbiota Transplantation Halts Progression of Human New-Onset Type 1 Diabetes in a Randomised Controlled Trial","volume":"70","author":"Nikolic","year":"2021","journal-title":"Gut"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"204062232211174","DOI":"10.1177\/20406223221117449","article-title":"Fecal Microbiota Transplantation Treatment for Type 1 Diabetes Mellitus with Malnutrition: A Case Report","volume":"13","author":"Xie","year":"2022","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Crudele, L., Gadaleta, R.M., Cariello, M., and Moschetta, A. (2023). Gut Microbiota in the Pathogenesis and Therapeutic Approaches of Diabetes. eBioMedicine, 97.","DOI":"10.1016\/j.ebiom.2023.104821"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5946\/ce.2021.072","article-title":"Fecal Microbiota Transplantation: Is It Safe?","volume":"54","author":"Park","year":"2021","journal-title":"Clin. 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