{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:00:45Z","timestamp":1760144445708,"version":"build-2065373602"},"reference-count":100,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A retrospective study in patients who underwent video capsule endoscopy (VCE) between 2006 and 2016 was conducted in the Clinic for gastroenterology and Hepatology, University Clinical Center of Serbia. A total of 245 patients underwent VCE. In 198 patients the indication was obscure gastrointestinal bleeding (OGIB), with 92 patients having overt and the other 106 occult bleeding. The remaining 47 patients underwent VCE due to suspected small bowel (SB) disease (i.e., Von Hippel\u2013Lindau syndrome, familial adenomatous polyposis, Peutz Jeghers syndrome, Crohn\u2019s disease, prolonged diarrhea, abdominal pain, congenital lymphangiectasia, protein-losing enteropathy, tumors, refractory celiac disease, etc.). VCE identified a source of bleeding in 38.9% of patients (in the obscure overt group in 48.9% of patients, and in the obscure occult group in 30.2% of patients). The most common findings were angiodysplasias, tumors, Meckel\u2019s diverticulum and Crohn\u2019s disease. In the smaller group of patients with an indication other than OGIB, 38.3% of patients had positive VCE findings. The most common indication is OGIB, and the best candidates are patients with overt bleeding; patients with IBD should be evaluated in this setting.<\/jats:p>","DOI":"10.3390\/diagnostics14090862","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T08:08:27Z","timestamp":1713859707000},"page":"862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Could Capsule Endoscopy Be Useful in Detection of Suspected Small Bowel Bleeding and IBD-10 Years of Single Center Experience"],"prefix":"10.3390","volume":"14","author":[{"given":"Jelena","family":"Martinov Nestorov","sequence":"first","affiliation":[{"name":"School of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Sokic-Milutinovic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Pavlovic Markovic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-0582","authenticated-orcid":false,"given":"Miodrag","family":"Krstic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/gut.2007.127852","article-title":"Recent developments in capsule endoscopy","volume":"57","author":"Galmiche","year":"2008","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.3748\/wjg.v13.i46.6140","article-title":"Small bowel capsule endoscopy in 2007: Indications, risks and limitations","volume":"13","author":"Rondonotti","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.dld.2006.09.007","article-title":"Capsule endoscopy: Where are we after 6 years of clinical use?","volume":"38","author":"Pennazio","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"ref_4","first-page":"168","article-title":"Capsule endoscopy for the diagnosis and follow up of Crohn\u2019s disease: A comprehensive review of current status","volume":"30","author":"Jensen","year":"2017","journal-title":"Ann. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.gie.2013.06.026","article-title":"ASGE Technology Committee. Wireless capsule endoscopy","volume":"78","author":"Wang","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.gie.2020.12.001","article-title":"Video caspule endoscopy","volume":"93","author":"Melson","year":"2021","journal-title":"Gastrointest. Endosc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1053\/j.gastro.2007.06.008","article-title":"American Gastrointestinal Association (AGA) Institute medical position statement on obscure gastrointestinal bleeding","volume":"133","author":"Raju","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1055\/s-2003-40244","article-title":"Diagnostic value of Endoscopic Capsule in Patients with Obscure Digestive Bleeding: Blinded Comparasion with Video Push-Enteroscopy","volume":"35","author":"Saurin","year":"2003","journal-title":"Endoscopy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/MEG.0000000000000603","article-title":"Capsule endoscopy is useful diagnostic tool for diagnosing Meckel\u2019s diverticulum","volume":"28","author":"Krstic","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0016-5107(04)00523-1","article-title":"Meta-analysis of capsule endoscopy versus alternative modalities in the diagnosis of small bowel pathologies","volume":"59","author":"Lewis","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Nam, J.H., Lee, K.H., and Lim, Y.J. (2021). Examination of entire gastrointestinal tract: A perspective of mouth to anus (M2A) capsule endoscopy. Diagnostics, 11.","DOI":"10.3390\/diagnostics11081367"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/den.13346","article-title":"Caspule endoscopy for small-intestinal disorders: Current status","volume":"31","author":"Hosoe","year":"2019","journal-title":"Dig. Endosc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.gie.2009.09.031","article-title":"Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: A systematic review","volume":"71","author":"Liao","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/ajg.2015.246","article-title":"ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding","volume":"110","author":"Gerson","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0016-5085(00)70430-6","article-title":"AGA technical rewiew on the evaluation and management of occult and obscure gastrointestinal bleeding","volume":"118","author":"Zuckerman","year":"2000","journal-title":"Gastroeneterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0016-5107(02)70037-0","article-title":"Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding: Results of a pilot study","volume":"56","author":"Lewis","year":"2002","journal-title":"Gastrointest. Endosc."},{"key":"ref_17","first-page":"AB88","article-title":"Comparison of wireless endoscopic capsule and push-enteroscopy in patients with obscure occult\/overt digestive bleeding: Results of a prospective, blinded, multicenter trial","volume":"55","author":"Delvaux","year":"2002","journal-title":"Gastrointest. Endosc."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Contaldo, A., Losurdo, G., Albano, F., Iannone, A., Barone, M., Ierardi, E., Di Leo, A., and Principi, M. (2019). The Spectrum of Small Intestinal Lesions in Patients with Unexplained Iron Deficiency Anemia Detected by Video Capsule Endoscopy. Medicina, 55.","DOI":"10.3390\/medicina55030059"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1053\/gast.2002.35988","article-title":"A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease","volume":"123","author":"Costamagna","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1111\/j.1572-0241.2002.07021.x","article-title":"Initial experience of wireless-capsule endoscopy for evaluating occult gastrointestinal bleeding and suspected small bowel pathology","volume":"97","author":"Scapa","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1055\/s-2002-33446","article-title":"The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding","volume":"34","author":"Ell","year":"2002","journal-title":"Endoscopy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1136\/gut.52.8.1122","article-title":"Wireless capsule endoscopy: A comparison with push enteroscopy in patients with gastroscopy and colonoscopy negative gastrointestinal bleeding","volume":"52","author":"Mylonaki","year":"2003","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0016-5107(03)02862-1","article-title":"A prospective comparison of capsule endoscopy and push enteroscopy in patients with GI bleeding of obscure origin","volume":"59","author":"Adler","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2036.2004.02067.x","article-title":"Wireless capsule endoscopy in patients with obscure gastrointestinal bleeding: A comparative study with push enteroscopy","volume":"20","author":"Mata","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0016-5107(05)00372-X","article-title":"A prospective two-center study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding","volume":"61","author":"Hartmann","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1053\/j.gastro.2010.01.047","article-title":"Does capsule endoscopy improve outcomes in obscure gastrointestinal bleeding? Randomized trial versus dedicated small bowel radiography","volume":"138","author":"Laine","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.gie.2009.12.009","article-title":"Negative capsule endoscopy without subsequent enteroscopy does not predict lower long-term rebleeding rates in patients with obscure GI bleeding","volume":"71","author":"Park","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.cgh.2012.05.024","article-title":"Factors associated with diagnosis of obscure gastrointestinal bleeding by video capsule enteroscopy","volume":"10","author":"Lepileur","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.gie.2012.07.035","article-title":"Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: A systematic review","volume":"76","author":"Koulaouzidis","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1111\/j.1572-0241.2005.00274.x","article-title":"A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding","volume":"100","author":"Triester","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1053\/j.gastro.2003.11.057","article-title":"Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: Report of 100 consecutive cases","volume":"126","author":"Pennazio","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-0031-1291614","article-title":"Yield and impact of emergency capsule enteroscopy in severe obscure-overt gastrointestinal bleeding","volume":"44","author":"Lecleire","year":"2012","journal-title":"Endoscopy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/00042737-200608000-00014","article-title":"Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding","volume":"18","author":"Estevez","year":"2006","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_34","first-page":"676","article-title":"Timing of capsule endoscopy influences the diagnosis and outcome in obscureovert gastrointestinal bleeding","volume":"59","author":"Yamada","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"ref_35","first-page":"273","article-title":"Factors predicting the diagnostic yield and intervention in obscure gastrointestinal bleeding investigated using capsule endoscopy","volume":"18","author":"Sidhu","year":"2009","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/MEG.0b013e3282fb2a53","article-title":"Impact of capsule endoscopy on outcome in mid-intestinal bleeding: A multicentre cohort study in 285 patients","volume":"20","author":"Albert","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.gie.2012.11.041","article-title":"Timing of video capsule endoscopy relative to overt obscure GI bleeding: Implications from a retrospective study","volume":"77","author":"Singh","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.gie.2014.09.035","article-title":"Emergency video capsule endoscopy in patients with acute severe GI bleeding and negative upper endoscopy results","volume":"81","author":"Schlag","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1055\/s-0034-1391855","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline","volume":"47","author":"Pennazio","year":"2015","journal-title":"Endoscopy"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1572-0241.2007.01058.x","article-title":"Capsule endoscopy versus computed tomographic or standard angiography for the diagnosis of obscure gastrointestinal bleeding","volume":"102","author":"Saperas","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/1754-9485.12035","article-title":"CT enterography in obscure gastrointestinal bleeding: A systematic review and meta-analysis","volume":"57","author":"Wang","year":"2013","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1440-1746.2010.06530.x","article-title":"Double balloon enteroscopy and capsule endoscopy for obscure gastrointestinal bleeding: An updated meta-analysis","volume":"26","author":"Teshima","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cgh.2008.01.005","article-title":"Double-Balloon Enteroscopy and Capsule Endoscopy Have Comparable Diagnostic Yield in Small-Bowel Disease: A Meta-Analysis","volume":"6","author":"Pasha","year":"2008","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00535-004-1532-5","article-title":"The role of video capsule endoscopy for evaluating obscure gastrointestinal bleeding: Usefulness of early use","volume":"40","author":"Bresci","year":"2005","journal-title":"J. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.gie.2005.06.049","article-title":"Impact of capsule endoscopy in obscure small-bowel bleeding: Defining strict criteria for a favorable outcome","volume":"62","author":"Viazis","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.cgh.2012.08.035","article-title":"Factors Associated with Positive Findings From Capsule Endoscopy in Patients with Obscure Gastrointestinal Bleeding","volume":"10","author":"Shahidi","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1572-0241.2006.00506.x","article-title":"A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn\u2019s disease","volume":"101","author":"Triester","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1055\/s-2005-870315","article-title":"ICCE consensus for inflammatory bowel disease","volume":"37","author":"Kornbluth","year":"2005","journal-title":"Endoscopy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/gut.52.3.390","article-title":"Diagnosing small bowel Crohn\u2019s disease with wireless capsule endoscopy","volume":"52","author":"Fireman","year":"2003","journal-title":"Gut"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1055\/s-2003-40241","article-title":"Capsule endoscopy in patients with suspected Crohn\u2019s disease and negative endoscopy","volume":"35","author":"Caunedo","year":"2003","journal-title":"Endoscopy"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0016-5107(04)02571-4","article-title":"Capsule endoscopy vs. push enteroscopy and enteroclysis in suspected small-bowel Crohn\u2019s disease","volume":"61","author":"Chong","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1111\/j.1572-0241.2006.00761.x","article-title":"The risk of retention of the capsule endoscope in patients with known or suspected Crohn\u2019s disease","volume":"101","author":"Cheifetz","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/ajg.2009.713","article-title":"Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn\u2019s disease: A meta-analysis","volume":"105","author":"Dionisio","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cgh.2010.10.019","article-title":"Diagnostic accuracy of capsule endoscopy for small bowel Crohn\u2019s disease is superior to that of MR enterography or CT enterography","volume":"9","author":"Jensen","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/MIB.0b013e31828133c1","article-title":"The prevalence and outcome of jejunal lesions visualized by small bowel capsule endoscopy in Crohn\u2019s disease","volume":"19","author":"Flamant","year":"2013","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ajg.2015.221","article-title":"Detection of Small Bowel Mucosal Healing and Deep Remission in Patients with Known Small Bowel Crohn\u2019s Disease Using Biomarkers, Capsule Endoscopy, and Imaging","volume":"110","author":"Kopylov","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2036.2006.03054.x","article-title":"Review article. Capsule endoscopy- are all small intestinal lesions Chron\u2019s disease?","volume":"24","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_58","first-page":"438","article-title":"Video capsule endoscopy in inflammatory bowel disease","volume":"21","author":"Legnani","year":"2005","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1053\/j.gastro.2005.03.020","article-title":"A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy","volume":"128","author":"Maiden","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1046\/j.1365-2036.2003.01556.x","article-title":"Review article. The advent of capsule endoscopy-a not so futuristic approach to obscure gastrointestinal bleeding","volume":"17","author":"Lewis","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2036.2007.03556.x","article-title":"Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change","volume":"27","author":"Gralnek","year":"2008","journal-title":"Aliment. Phramacol. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/cncr.21975","article-title":"Increased diagnostic yield of small bowel tumors with capsule endoscopy","volume":"107","author":"Cobrin","year":"2006","journal-title":"Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s10620-006-9483-8","article-title":"Small-Bowel Tumors Detected by Wireless Capsule Endoscopy","volume":"52","author":"Schwartz","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"A83","DOI":"10.1016\/S0002-9270(02)05390-X","article-title":"Wireless capsule endoscopy requiring surgical intervention: The world\u2019s experience","volume":"97","author":"Barkin","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/cncr.20404","article-title":"Adenocarcinoma of the small bowel: Presentation, factors and outcome of 217 patients","volume":"101","author":"Dabaja","year":"2004","journal-title":"Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5946\/ce.2016.49.1.21","article-title":"The Usefulness of Capsule Endoscopy for Small Bowel Tumors","volume":"49","author":"Cheung","year":"2016","journal-title":"Clin. Endosc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1148\/radiol.11110143","article-title":"Prospective Blinded Comparison of Wireless Capsule Endoscopy and Multiphase CT Enterography in Obscure Gastrointestinal Bleeding","volume":"260","author":"Huprich","year":"2011","journal-title":"Radiology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00261-012-9892-4","article-title":"Comparison of MR enteroclysis with video capsule endoscopy in the inves-tigation of small-intestinal disease","volume":"38","author":"Bouman","year":"2013","journal-title":"Abdom. Imaging"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1007\/s10620-011-1773-0","article-title":"CT-enterography may identify small bowel tumors not detected by capsule endoscopy: Eight years experience at Mayo Clinic Rochester","volume":"56","author":"Hakim","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.gie.2011.07.022","article-title":"Development of a novel index to discriminate bulge from mass on small-bowel capsule endoscopy","volume":"74","author":"Girelli","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1055\/s-2008-1077483","article-title":"Bulge or mass? A diagnostic dilemma of capsule endoscopy","volume":"40","author":"Girelli","year":"2008","journal-title":"Endoscopy"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.17235\/reed.2017.4629\/2016","article-title":"Validation of SPICE, a method to differentiate small bowel submucosal lesions from innocent bulges on capsule endoscopy","volume":"109","author":"Rodrigues","year":"2017","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Min, M., Noujaim, M.G., Green, J., Schlieve, C.R., Vaze, A., Cahan, M.A., and Cave, D.R. (2019). Role of Mucosal Protrusion Angle in Discriminating between True and False Masses of the Small Bowel on Video Capsule Endoscopy. J. Clin. Med., 8.","DOI":"10.3390\/jcm8040418"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.3748\/wjg.14.5245","article-title":"Capsule endoscopy in neoplastic diseases","volume":"14","author":"Pennazio","year":"2008","journal-title":"World. J. Gastroenterol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/a-0576-0566","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review","volume":"50","author":"Rondonotti","year":"2018","journal-title":"Endoscopy"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.gie.2005.07.034","article-title":"Capsule endoscopy in celiac disease","volume":"62","author":"Green","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_77","unstructured":"Muhammad, A. (2006, January 7). The nature, location and extent of small bowel mucosal lesions in celiac disease as observed by wireless capsule endoscopy. Proceedings of the ICCE 2006, Boca Raton, FL, USA."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1572-0241.2007.01238.x","article-title":"Video capsule enteroscopy in the diagnosis of celiac disease: A multicenter study","volume":"102","author":"Rondonotti","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.gie.2011.05.049","article-title":"Capsule endoscopy in nonresponsive celiac disease","volume":"74","author":"Atlas","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/ajg.2012.199","article-title":"Diagnostic yield of capsule endoscopy in refractory celiac disease","volume":"107","author":"Barret","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.gie.2012.09.031","article-title":"Capsule endoscopy in adult celiac disease: A potential role in equivocal cases of celiac disease?","volume":"77","author":"Kurien","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3748\/wjg.v23.i4.703","article-title":"Role of capsule endoscopy in suspected celiac disease: A European multi-centre study","volume":"23","author":"Fernandez","year":"2017","journal-title":"World. J. Gastroenterol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1055\/s-2007-966239","article-title":"Capsule endoscopy in refractory celiac disease","volume":"39","author":"Daum","year":"2007","journal-title":"Endoscopy"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1572-0241.2005.41506.x","article-title":"The utility of capsule endoscopy small bowel surveillence in patients with polyposis","volume":"100","author":"Burke","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0016-5107(05)00289-0","article-title":"A prospective trial comparing wireless capsule endoscopy and barium contrast series for small-bowel surveillence in hereditary GI polyposis syndroms","volume":"61","author":"Mata","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.gie.2005.12.014","article-title":"Video capsule endoscopy compared with standard endoscopy for the evaluation of small-bowel polyps in persons with familial adenomatous polyposis","volume":"64","author":"Wong","year":"2006","journal-title":"Gastrointest. Endosc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gie.2007.07.048","article-title":"Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis","volume":"67","author":"Iaquinto","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1055\/s-2007-966930","article-title":"Literature review and recommendations for clinical applications of small-bowel capsule endoscopy, based on a panel discussion by international experts. Consensus statements for small.bowel endoscopy, 2006\/2007","volume":"39","author":"Mergener","year":"2007","journal-title":"Endoscopy"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.gie.2007.11.055","article-title":"How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center","volume":"68","author":"Clarke","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1055\/s-2003-41595","article-title":"Capsule endoscopy is feasible in small children","volume":"35","author":"Aabakken","year":"2003","journal-title":"Endoscopy"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0016-5107(04)02052-8","article-title":"Endoscopic placement of the capsule endoscope in children","volume":"60","author":"Barth","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S1542-3565(04)00715-3","article-title":"Wireless capsule endoscopy for obscure small-bowel disorders: Final results of the first pediatric controlled trial","volume":"3","author":"Dubois","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.gie.2007.01.033","article-title":"Endoscopic placement of the small-bowel video capsule by using a capsule endoscope delivery device","volume":"65","author":"Holden","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.gie.2016.08.027","article-title":"Clinical outcomes of negative small bowel capsule endoscopy for small bowel bleeding- a systematic review and meta-analysis","volume":"85","author":"Yung","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.dld.2017.12.031","article-title":"Meta-analysis shows similar re-bleeding rates among Western and Eastern populations after index video capsule endoscopy","volume":"50","author":"Tziatzios","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Wang, J.C., Pan, J., Liu, Y.W., Sun, F.Y., Qian, Y.Y., Jiang, X., Zou, W.B., Xia, J., Jiang, B., and Ru, N. (2020). Adverse events of video capsule endoscopy over the past two decades: A systematic review and proportion meta analysis. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01491-w"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.gie.2005.05.002","article-title":"Complications, limitations and failures of capsule endoscopy: A review of 733 cases","volume":"62","author":"Rondonotti","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1067\/mge.2003.118","article-title":"Video capsule impaction at the cricopharyngeus: A first report of this complication and its successful resolution","volume":"57","author":"Fleischer","year":"2003","journal-title":"Gastrointest. Endosc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1055\/s-2003-41527","article-title":"Aspiration of an M2A capsule","volume":"35","author":"Schneider","year":"2003","journal-title":"Endoscopy"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Kim, H.S., and Chun, H.J. (2021). Capsule Endoscopy: Pitfalls and Approaches to Overcome. Diagnostics, 11.","DOI":"10.3390\/diagnostics11101765"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/9\/862\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:32:34Z","timestamp":1760106754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/9\/862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":100,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["diagnostics14090862"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14090862","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}