{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:21:44Z","timestamp":1792693304635,"version":"4.5.0"},"reference-count":106,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PhD School, Carol Davila University and Pharmacy, Bucharest, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Postpartum depression (PPD) is a disabling condition that has recently shown an increase in prevalence, becoming an essential public health problem. This study is a qualitative review summarizing the most frequent risk factors associated with PPD, evaluating molecular aspects of PPD and current approaches to detect and prevent PPD. The most prevalent risk factors were detected in the areas of economic and social factors, obstetrical history, lifestyle, and history of mental illness. Research on the genetic basis for PPD has taken place in recent years to identify the genes responsible for establishing targeted therapeutic methods and understanding its pathogenesis. The most frequently studied candidate gene was the serotonin transporter gene (SERT) associated with PPD. Among biological studies, antidepressants and psychological interventions provided the most evidence of successful intervention. The obstetrician can serve an essential role in screening for and treating PPD. Postpartum women with risk factors should be screened using the Edinburgh Postnatal Depression Scale (EPDS), but, at the moment, there are no prevention programs in Europe. In conclusion, data from this review increase concerns among this vulnerable population and can be used to design a screening tool for high-risk pregnant women and create a prevention program.<\/jats:p>","DOI":"10.3390\/diagnostics14090865","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T08:08:27Z","timestamp":1713859707000},"page":"865","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Postpartum Depression: Etiology, Treatment, and Consequences for Maternal Care"],"prefix":"10.3390","volume":"14","author":[{"given":"Daiana Anne-Marie","family":"Dimcea","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-1535","authenticated-orcid":false,"given":"R\u0103zvan-Cosmin","family":"Petca","sequence":"additional","affiliation":[{"name":"Department of Urology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Urology, \u201cProf. Dr. Th. Burghele\u201d Clinical Hospital, 050659 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai Cristian","family":"Dumitra\u0219cu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, University Emergency Hospital, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florica","family":"\u0218andru","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology, Elias University Emergency Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Mehedin\u021bu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-0978","authenticated-orcid":false,"given":"Aida","family":"Petca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Elias University Emergency Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2001). The World Health Report: 2001, Mental Health: New Understanding, New Hope, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/42390."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/jclp.20644","article-title":"Postpartum depression: What we know","volume":"65","year":"2009","journal-title":"J. Clin. Psychol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.]. Available online: https:\/\/www.psychiatry.org\/psychiatrists\/practice\/dsm.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S1701-2163(16)35240-9","article-title":"Postpartum depression: Diagnostic and treatment","volume":"34","author":"Sharma","year":"2012","journal-title":"J. Obs. Gynaecol. Can."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Dadi, A.F., Miller, E.R., and Mwanri, L. (2020). Postnatal depression and its association with adverse infant health outcomes in low- and middle-income countries: A systematic review and meta-analysis. BMC Pregnancy Childbirth, 20.","DOI":"10.1186\/s12884-020-03092-7"},{"key":"ref_6","first-page":"e30898","article-title":"Risk Factors of Postpartum Depression","volume":"14","author":"Agrawal","year":"2022","journal-title":"Cureus"},{"key":"ref_7","first-page":"248","article-title":"Economic and health predictors of national postpartum depression prevalence: A systematic review, meta-analysis and meta-regression of 291 studies from 56 countries","volume":"8","author":"Anaya","year":"2017","journal-title":"Front. Psychiatry"},{"key":"ref_8","first-page":"139","article-title":"Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: A systematic review","volume":"90","author":"Fisher","year":"2012","journal-title":"Bull. WHO"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102567","DOI":"10.1016\/j.ajp.2021.102567","article-title":"Depressed Motherhood: Prevalence and Covariates of Maternal Postpartum Depression among Urban Mothers in India","volume":"57","author":"Lanjewar","year":"2021","journal-title":"Asian J. Psychiatr."},{"key":"ref_10","first-page":"101","article-title":"Prevalence of postpartum depression and its associated factors within a year after birth in Semey, Kazakhstan: A cross sectional study","volume":"16","author":"Abenova","year":"2022","journal-title":"Clin. Epidemiol. Glob. Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41398-021-01663-6","article-title":"Mapping global prevalence of depression among postpartum women","volume":"11","author":"Wang","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chen, Q., Li, W., Xiong, J., and Zheng, X. (2022). Prevalence and Risk factors associated postpartum depression during the COVID-19 Pandemic: A literature review and meta-analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19042219"},{"key":"ref_13","first-page":"1745506519844044","article-title":"Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes","volume":"15","author":"Slomian","year":"2019","journal-title":"Sage J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev-med-041217-011106","article-title":"Postpartum depression: Pathophysiology, treatment and emerging therapeutics","volume":"70","author":"Stewart","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00737-012-0274-2","article-title":"A longitudinal study of postpartum depressive symptoms: Multilevel growth curve analyses of emotion regulation strategies, breastfeeding self-efficacy, and social support","volume":"15","author":"Haga","year":"2012","journal-title":"Arch. Womens Ment. Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3691752","DOI":"10.1155\/2019\/3691752","article-title":"Assessment of postpartum depression and anxiety among females attending primary health care facilities in Qalyubia Governorate, Egypt","volume":"2019","author":"Wassif","year":"2019","journal-title":"J. Environ. Public. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1552-6909.2007.00191.x","article-title":"Depression symptom prevalence and demographic risk factors among U.S. women during the first 2 years postpartum","volume":"36","author":"Mayberry","year":"2007","journal-title":"J. Obs. Gynecol. Neonatal Nurs."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2147\/IJWH.S51436","article-title":"Prevalence and risk factors for postpartum depressive symptoms in Argentina: A cross-sectional study","volume":"5","author":"Mathisen","year":"2013","journal-title":"Int. J. Womens Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ajog.2008.11.033","article-title":"Postpartum depression","volume":"200","author":"Pearlstein","year":"2009","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_20","first-page":"410","article-title":"The neuroendocrinological aspects of pregnancy and postpartum depression","volume":"15","author":"Trifu","year":"2019","journal-title":"Acta Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1089\/jwh.2007.0725","article-title":"The psychoneuroimmunology of postpartum depression","volume":"17","author":"Corwin","year":"2008","journal-title":"J. Womens Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1017\/S1092852900010312","article-title":"The neurobiology of postpartum depression","volume":"10","author":"Zonana","year":"2005","journal-title":"CNS Spectr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jpsychires.2004.01.011","article-title":"Alterations in platelet serotonin transporter binding in women with postpartum onset major depression","volume":"38","author":"Newport","year":"2004","journal-title":"J. Psychiatry Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.fertnstert.2007.03.059","article-title":"Serotonin 1A receptor reductions in postpartum depression: A positron emission tomography study","volume":"89","author":"Wisner","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1192\/bjp.bp.107.045427","article-title":"Mood changes after delivery: Role of the serotonin transporter gene","volume":"193","author":"Sanjuan","year":"2008","journal-title":"Br. J. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tins.2012.08.004","article-title":"Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors","volume":"35","author":"Neumann","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(10)60887-2","article-title":"Violence against women by their intimate partner during pregnancy and postnatal depression: A prospective cohort study","volume":"376","author":"Ludermir","year":"2010","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jad.2010.10.024","article-title":"Employment, income, and education and risk of postpartum depression: The Osaka Maternal and Child Health Study","volume":"130","author":"Miyake","year":"2011","journal-title":"J. Affect. Disord."},{"key":"ref_29","first-page":"3","article-title":"The relationship between employment status and depression symptomatology among women at risk for postpartum depression","volume":"13","author":"Lewis","year":"2017","journal-title":"Womens Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2011.12.036","article-title":"Depression as a disease of modernity: Explanations for increasing prevalence","volume":"140","author":"Hidaka","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"152210","DOI":"10.1016\/j.comppsych.2020.152210","article-title":"Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort","volume":"103","author":"Chia","year":"2020","journal-title":"Compr. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/jehp.jehp_9_16","article-title":"Postpartum depression risk factors: A narrative review","volume":"6","author":"Ghaedrahmati","year":"2017","journal-title":"J. Educ. Health Promot."},{"key":"ref_33","unstructured":"Payne, J.L., and Osborne, L.M. (2019). Biomarkers of Postpartum Psychiatric Disorders, Academic Press."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11920-015-0617-6","article-title":"Is postpartum depression a distinct disorder?","volume":"17","year":"2015","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00737-018-0891-5","article-title":"Is depression more likely following childbirth? A population-based study","volume":"22","author":"Silverman","year":"2019","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1176\/appi.ajp.2015.15010085","article-title":"Heritability of perinatal depression and genetic overlap with nonperinatal depression","volume":"173","author":"Viktorin","year":"2016","journal-title":"American J. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1176\/appi.focus.20190045","article-title":"Is postpartum depression different from depression occurring outside of the perinatal period? A review of the evidence","volume":"18","author":"Batt","year":"2020","journal-title":"Focus"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/GRF.0000000000000368","article-title":"Predictors of postpartum depression: A comprehensive review of the last decade of evidence","volume":"61","author":"Guintivano","year":"2018","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/0167482X.2012.759555","article-title":"Association of a serotonin transporter gene polymorphism (5-HTTLPR) and stressful life events with postpartum depressive symptoms: A population-based study","volume":"34","author":"Pinheiro","year":"2013","journal-title":"J. Psychosom. Obstet. Gynecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00737-013-0349-8","article-title":"Postpartum depression symptoms associated with Val158Met COMT polymorphism","volume":"16","author":"Miranda","year":"2013","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fgene.2015.00243","article-title":"Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy","volume":"6","author":"Bell","year":"2015","journal-title":"Front. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00737-013-0373-8","article-title":"Association study of the estrogen receptor gene ESR1 with postpartum depression e a pilot study","volume":"16","author":"Pinsonneault","year":"2013","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/YPG.0b013e328341a3c1","article-title":"Postpartum depression symptoms: A case-control study on monoaminergic functional polymorphisms and environmental stressors","volume":"21","author":"Comasco","year":"2011","journal-title":"Psychiatr. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.pnpbp.2009.07.013","article-title":"The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT","volume":"33","author":"Doornbos","year":"2009","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.yhbeh.2017.06.008","article-title":"Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway","volume":"94","author":"Hellgren","year":"2017","journal-title":"Horm. Behav."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.biopsych.2012.03.032","article-title":"Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice","volume":"72","author":"Bath","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1176\/appi.ajp.2009.09030417","article-title":"Genome-wide linkage and follow-up association study of postpartum mood symptoms","volume":"166","author":"Mahon","year":"2009","journal-title":"Am. J. Psychiatry"},{"key":"ref_48","unstructured":"Wenzel, A. (2023, June 14). Postpartum Depression. Available online: https:\/\/www.britannica.com\/science\/postpartum-depression."},{"key":"ref_49","unstructured":"Mughal, S., Azhar, Y., and Siddiqui, Q. (2023, September 15). Postpartum Depression [Updated 7 October 2022], StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519070\/."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/01.AOG.0000183597.31630.db","article-title":"Perinatal depression: A systematic review of prevalence and incidence","volume":"106","author":"Gavin","year":"2005","journal-title":"Obs. Gynecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1001\/jama.296.21.2582","article-title":"New parents and mental disorders: A population-based register study","volume":"296","author":"Laursen","year":"2006","journal-title":"JAMA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1353\/hpu.2012.0037","article-title":"Postpartum depression: A review","volume":"23","author":"Patel","year":"2012","journal-title":"J. Health Care Poor Underserved"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/jmwh.12104","article-title":"Management of postpartum depression","volume":"58","author":"Guille","year":"2013","journal-title":"J. Midwifery Woemen\u2019s Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0884217505274583","article-title":"Identifying and treating postpartum depression","volume":"34","author":"Horowitz","year":"2005","journal-title":"J. Obs. Gynecol. Neonatal Nurs."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.midw.2014.02.008","article-title":"Validation of the Edinburgh Postnatal Depression Scale as a screening tool for postpartum depression in a clinical sample in Hungary","volume":"30","author":"Toreki","year":"2014","journal-title":"Midwifery"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/GRF.0b013e3181b5a57c","article-title":"The identification of postpartum depression","volume":"52","author":"Sit","year":"2009","journal-title":"Clin. Obs. Gynecol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/0167482X.2010.484513","article-title":"Postpartum depression: An original survey of screening practices within a healthcare system","volume":"31","author":"Park","year":"2010","journal-title":"J. Pschosom Obs. Gynaecol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00737-005-0076-x","article-title":"Acceptability of routine antenatal psychosocial assessments to women from English and non-English speaking backgrounds","volume":"8","author":"Matthey","year":"2005","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41398-021-01245-6","article-title":"Early identification of postpartum depression using demographic, clinical, and digital phenotyping","volume":"11","author":"Hahn","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"El-Hachem, C., Rohayem, J., Bou Khalil, R., Richa, S., Kesrouan, A., Gemayel, R., Aouad, N., Hatab, N., Zaccak, E., and Yahji, N. (2014). Early identification of women at risk of postpartum depression using the Edinburgh Postnatal Depression Scale (EPDS) in a sample of Lebanese women. BMC Psychiatry, 14.","DOI":"10.1186\/s12888-014-0242-7"},{"key":"ref_61","first-page":"e31124","article-title":"Postpartum Depression and Its Biological Biomarkers","volume":"14","author":"Rathi","year":"2022","journal-title":"Cureus"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/17446651.2017.1347500","article-title":"The functioning of the hypothalamic-pituitary-adrenal (HPA) axis in postpartum depressive states: A systematic review","volume":"12","year":"2017","journal-title":"Expert. Rev. Endocrinol. Metab."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yfrne.2018.12.001","article-title":"Pathophysiological mechanisms implicated in postpartum depression","volume":"52","author":"Payne","year":"2019","journal-title":"Front. Neuroendocr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.psyneuen.2018.09.031","article-title":"Stress, female reproduction and pregnancy","volume":"100","author":"Valsamakis","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5830\/CVJA-2016-021","article-title":"Physiological changes in pregnancy","volume":"27","author":"Tolppanen","year":"2016","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1210\/er.2004-0025","article-title":"The hypothalamic-pituitary-adrenal axis in pregnancy: Challenges in disease detection and treatment","volume":"26","author":"Lindsay","year":"2005","journal-title":"Endocr. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1365-2826.2008.01735.x","article-title":"Adaptive responses of the maternal hypothalamic-pituitary-adrenal axis during pregnancy and lactation","volume":"20","author":"Brunton","year":"2008","journal-title":"J. Neuroendocr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biopsycho.2013.11.002","article-title":"Diurnal cortisol patterns and psychiatric symptoms in pregnancy: Short-term longitudinal study","volume":"96","author":"Tang","year":"2014","journal-title":"Biol. Psychol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.steroids.2014.12.007","article-title":"Quantification of neurosteroids during pregnancy using selective ion monitoring mass spectrometry","volume":"95","author":"Pennell","year":"2015","journal-title":"Steroids"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3389\/fpsyg.2019.01033","article-title":"The Role of Allopregnanolone in Pregnancy in Predicting Postpartum Anxiety Symptoms","volume":"10","author":"Osborne","year":"2019","journal-title":"Front. Psychol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00737-016-0644-2","article-title":"Oxytocin course over pregnancy and postpartum period and the association with postpartum depressive symptoms","volume":"19","author":"Jobst","year":"2016","journal-title":"Arch. Womens Ment. Health"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.psyneuen.2009.10.015","article-title":"Thyroid function 48h after delivery as a marker for subsequent postpartum depression","volume":"35","author":"Albacar","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.psyneuen.2012.10.004","article-title":"Thyroid function tests at delivery and risk for postpartum depressive symptoms","volume":"38","author":"Elenis","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jad.2017.08.058","article-title":"Thyroid peroxidase antibodies during early gestation and the subsequent risk of first-onset postpartum depression: A prospective cohort study","volume":"225","author":"Wesseloo","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1746-4358-2-6","article-title":"A new paradigm for depression in new mothers: The central role of inflammation and how breastfeeding and anti-inflammatory treatments protect maternal mental health","volume":"2","year":"2007","journal-title":"Int. Breastfeed. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/1099800408323220","article-title":"Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum","volume":"10","author":"Corwin","year":"2008","journal-title":"Biol. Res. Nurs."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.psychres.2016.02.022","article-title":"Elevated levels of Hs-CRP and IL-6 after delivery are associated with depression during the 6 months post partum","volume":"243","author":"Liu","year":"2016","journal-title":"Psychiatry Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s12035-016-9741-5","article-title":"Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms","volume":"54","author":"Roomruangwong","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ejca.2009.11.019","article-title":"Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study","volume":"46","author":"Agborsangaya","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.brainres.2010.09.062","article-title":"Endocrine induced changes in brain function during pregnancy","volume":"1364","author":"Brunton","year":"2010","journal-title":"Brain Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nn.4458","article-title":"Pregnancy leads to long-lasting changes in human brain structure","volume":"20","author":"Hoekzema","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-neuro-071714-034111","article-title":"Long-range neural synchrony in behavior","volume":"38","author":"Harris","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"148468","DOI":"10.1016\/j.brainres.2023.148468","article-title":"EEG coherence before and after giving birth","volume":"1816","author":"Sandoval","year":"2023","journal-title":"Brain Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMcp1607649","article-title":"Postpartum depression","volume":"375","author":"Stewart","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s10995-023-03655-y","article-title":"Psychodynamic psychotherapy for postpartum depression: A systematic review","volume":"27","author":"Valverde","year":"2023","journal-title":"Matern. Child Health J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"a3045","DOI":"10.1136\/bmj.a3045","article-title":"Clinical effectiveness of health visitor training in psychologically informed approaches for depression in postnatal women: Pragmatic cluster randomised trial in primary care","volume":"338","author":"Morrell","year":"2009","journal-title":"BMJ"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"950004","DOI":"10.3389\/fphar.2022.950004","article-title":"Comparative efficacy and acceptability of pharmacotherapies for postpartum depression: A systematic review and network meta-analysis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_88","first-page":"CD002018","article-title":"Antidepressant treatment for postnatal depression","volume":"9","author":"Molyneaux","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_89","first-page":"39","article-title":"Selective serotonin reuptake inhibitors (SSRIs) for postpartum depression (PPD): A systematic review of randomized clinical trials","volume":"152\u2013154","author":"Perelli","year":"2014","journal-title":"J. Affect. Disord."},{"key":"ref_90","first-page":"287","article-title":"Postpartum depression: An update","volume":"5","author":"Friedman","year":"2009","journal-title":"Women\u2019s Health"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2165\/00023210-200620030-00002","article-title":"Use of psychotropic medications in treating mood disorders during lactation: Practical recommendations","volume":"20","author":"Eskild","year":"2006","journal-title":"CNS Drugs"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.jp.7211352","article-title":"Selective serotonin reuptake inhibitor (SSRI) use during pregnancy and effects on the fetus and newborn: A meta-analysis","volume":"25","author":"Lattimore","year":"2005","journal-title":"J. Perinatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s40263-019-00605-7","article-title":"Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development","volume":"33","author":"Frieder","year":"2019","journal-title":"CNS Drugs"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jad.2022.09.143","article-title":"Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program","volume":"320","author":"Epperson","year":"2023","journal-title":"J. Affect. Disord."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0140-6736(18)31551-4","article-title":"Brexanolone injection in post-partum depression: Two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials","volume":"392","author":"Colquhoun","year":"2018","journal-title":"Lancet"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"l1400","DOI":"10.1136\/bmj.l1400","article-title":"Postpartum depression: New drug will be monitored at approved sites","volume":"364","author":"Dyer","year":"2019","journal-title":"BMJ"},{"key":"ref_97","unstructured":"(2024, March 16). US FDA Approves First Oral Treatment for Postpartum Depression, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-oral-treatment-postpartum-depression."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jamapsychiatry.2021.1559","article-title":"Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial","volume":"78","author":"Deligiannidis","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00737-020-01091-3","article-title":"Promising leads and pitfalls: A review of dietary supplements and hormone treatments to prevent postpartum blues and postpartum depression","volume":"24","author":"Dowlati","year":"2020","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/yct.0b013e318074e4b1","article-title":"The use of electroconvulsive therapy in postpartum affective disorders","volume":"23","author":"Forray","year":"2007","journal-title":"J. ECT"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/AOG.0000000000001809","article-title":"The obstetrician-gynecologist\u2019s role in detecting, preventing and treating depression","volume":"129","author":"Bhat","year":"2017","journal-title":"Obs. Gynecol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00737-014-0481-0","article-title":"Using the Patient Health Questionnaire (PHQ-9) and the Edinburgh Postnatal Depression Scale (EPDS) to assess suicidal ideation among pregnant women in Lima, Peru","volume":"18","author":"Zhong","year":"2015","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Committee on Obstetric Practice (2015). The American College of Obstetricians and Gynecologists Committee Opinion no. 630. Screening for perinatal depression. Obstet. Gynecol., 125, 1268\u20131271.","DOI":"10.1097\/01.AOG.0000465192.34779.dc"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/0167482X.2010.547639","article-title":"Postpartum mental health screening and diagnosis by obstetrician-gynecologists","volume":"32","author":"Leddy","year":"2011","journal-title":"J. Psychosom. Obstet. Gynecol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10995-005-2448-2","article-title":"Prevalence of Postpartum Depression in a Native American Population","volume":"9","author":"Baker","year":"2005","journal-title":"Matern. Child Health J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejogrb.2017.06.009","article-title":"Feasibility of screening and prevalence of prenatal depression in an obstetric setting in Spain","volume":"215","author":"Le","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/9\/865\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:32:39Z","timestamp":1760106759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/9\/865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":106,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["diagnostics14090865"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14090865","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}