{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:39:30Z","timestamp":1780616370317,"version":"3.54.1"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chang Gung Medical Foundation","award":["CMRPG2K0011"],"award-info":[{"award-number":["CMRPG2K0011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: A high incidence rate of nasopharyngeal carcinoma (NPC) has been observed in Southeast Asia compared to other parts of the world. Radiomics is a computational tool to predict outcomes and may be used as a prognostic biomarker for advanced NPC treated with concurrent chemoradiotherapy. Recently, radiomic analysis of the peripheral tumor microenvironment (TME), which is the region surrounding the gross tumor volume (GTV), has shown prognostic usefulness. In this study, not only was gross tumor volume (GTVt) analyzed but also tumor peripheral regions (GTVp) were explored in terms of the TME concept. Both radiomic features and delta radiomic features were analyzed using CT images acquired in a routine radiotherapy process. Methods: A total of 50 patients with NPC stages III, IVA, and IVB were enrolled between September 2004 and February 2014. Survival models were built using Cox regression with clinical factors (i.e., gender, age, overall stage, T stage, N stage, and treatment dose) and radiomic features. Radiomic features were extracted from GTVt and GTVp. GTVp was created surrounding GTVt for TME consideration. Furthermore, delta radiomics, which is the longitudinal change in quantitative radiomic features, was utilized for analysis. Finally, C-index values were computed using leave-one-out cross-validation (LOOCV) to evaluate the performances of all prognosis models. Results: Models were built for three different clinical outcomes, including overall survival (OS), local recurrence-free survival (LRFS), and progression-free survival (PFS). The range of the C-index in clinical factor models was (0.622, 0.729). All radiomics models, including delta radiomics models, were in the range of (0.718, 0.872). Among delta radiomics models, GTVt and GTVp were in the range of (0.833, 0.872) and (0.799, 0.834), respectively. Conclusions: Radiomic analysis on the proximal region surrounding the gross tumor volume of advanced NPC patients for survival outcome evaluation was investigated, and preliminary positive results were obtained. Radiomic models and delta radiomic models demonstrated performance that was either superior to or comparable with that of conventional clinical models.<\/jats:p>","DOI":"10.3390\/diagnostics14090941","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:39:42Z","timestamp":1714649982000},"page":"941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Utility of CT Radiomics and Delta Radiomics for Survival Evaluation in Locally Advanced Nasopharyngeal Carcinoma with Concurrent Chemoradiotherapy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7905-4958","authenticated-orcid":false,"given":"Yen-Cho","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Keelung Chang Gung Memorial Hospital, Keelung 20445, Taiwan"},{"name":"Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Tao-Yuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Keelung Chang Gung Memorial Hospital, Keelung 20445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jih-Hsiang","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Keelung Chang Gung Memorial Hospital, Keelung 20445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Chieh","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Linkuo Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Din-Li","family":"Tsan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Linkuo Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Tao-Yuan 33302, Taiwan"},{"name":"Department of Radiation Oncology, Linkuo Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"},{"name":"Particle Physics and Beam Delivery Core Laboratory, Linkou Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-1062","authenticated-orcid":false,"given":"Shu-Ju","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Tao-Yuan 33302, Taiwan"},{"name":"Department of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"},{"name":"Department of Nuclear Medicine, Linkou Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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