{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:02:37Z","timestamp":1760144557754,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Oligodontia can be isolated or syndromic, associated with other ectodermal abnormalities. The aim of the study was to perform hair examination in orthodontic patients diagnosed with oligodontia with a low clinical expression of symptoms of ectodermal origin. All available orthodontic patients diagnosed with oligodontia in the permanent dentition were enrolled. Hair examination included clinical evaluation of the patients\u2019 hair, trichoscopy, trichogram and evaluation of the hair shafts under a polarized light microscope. In total, 25 patients, 18 males and 7 females, aged 6 to 24 years were evaluated for the presence of dental and hair abnormalities. The number of congenitally absent teeth ranged from 6 to 24 teeth and diastemas, microdontia, taurodontism and altered tooth shape were found in 23 patients. Hair disorders were found in 68% of the subjects. Hypotrichosis, the heterogeneity of shaft color and loss of pigment, androgenetic alopecia, telogen effluvium, trichoschisis, pili canaliculi, trichorrhexis nodosa and pseudomoniletrix were observed. Trichoscopy and trichogram are valid non-invasive diagnostic tests which could be used to differentiate between isolated and syndromic oligodontia in patients with a low clinical expression of ectodermal symptoms.<\/jats:p>","DOI":"10.3390\/diagnostics14090945","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:39:42Z","timestamp":1714649982000},"page":"945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hair Evaluation in Orthodontic Patients with Oligodontia"],"prefix":"10.3390","volume":"14","author":[{"given":"Ma\u0142gorzata","family":"Zadurska","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Rakowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-6483","authenticated-orcid":false,"given":"Ewa","family":"Czochrowska","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Laskowska","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Perkowski","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Stru\u017cycka","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Rudnicka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-2581","authenticated-orcid":false,"given":"Agnieszka","family":"Jurek","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.joms.2009.09.012","article-title":"Implant treatment in patients with severe hypodontia: A retrospective evaluation","volume":"68","author":"Cune","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-263X.2006.00801.x","article-title":"Anomalies of tooth formation in hypohydrotic ectodermal dysplasia","volume":"17","author":"Lexner","year":"2007","journal-title":"Intern. J. Paediatr. Dent."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/000163501750157298","article-title":"Oligodontia in Danish schoolchildren","volume":"59","author":"Poulsen","year":"2001","journal-title":"Acta Odontol. Scand."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-263X.2006.00741.x","article-title":"Sings and symptoms from ectodermal organs in young Swedish individuals with oligodontia","volume":"16","author":"Bergendal","year":"2006","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/00016357.2016.1273385","article-title":"Dental anomaly patterns associated with tooth agenesis","volume":"75","author":"Choi","year":"2017","journal-title":"Acta Odontol. Scand."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.archoralbio.2018.08.014","article-title":"Non-syndromic tooth agenesis patterns and their association with other dental anomalies: A retrospective study","volume":"96","author":"Batista","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_7","first-page":"31","article-title":"Nonsyndromic tooth agenesis patterns and associated developmental dental anomalies: A literature review with radiographic illustrations","volume":"62","author":"Agarwal","year":"2013","journal-title":"Minerwa Stomatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.archoralbio.2005.06.004","article-title":"A Radiographic Study of Tooth Development in Hypodontia","volume":"51","author":"Uslenghi","year":"2006","journal-title":"Arch. Oral Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/pde.12674","article-title":"Scanning Electron Microscopic Hair Shaft Analysis in Ectodermal Dysplasia Syndromes","volume":"32","author":"Reed","year":"2015","journal-title":"Pediatr. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ajmg.1320530207","article-title":"Ectodermal dysplasias: A clinical classification and a causal review","volume":"53","author":"Pinheiro","year":"1994","journal-title":"Am. J. Med. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/jmg.38.9.579","article-title":"Ectodermal dysplasias: A new clinical\u2014Genetic classification","volume":"38","author":"Priolo","year":"2001","journal-title":"J. Med. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1365-2230.2003.01319.x","article-title":"Towards a new classification of ectodermal dysplasia","volume":"28","author":"Lamartine","year":"2003","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1601-0825.2001.70405.x","article-title":"Oligodontia is associated with extra-oral ectodermal symptoms and low whole salivary flow rates","volume":"7","author":"Nordgarden","year":"2001","journal-title":"Oral Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/ocr.12214","article-title":"Disturbances of dental development distinguish patients with oligodontia-ectodermal dysplasia from isolated oligodontia","volume":"21","author":"Dhamo","year":"2018","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.det.2018.05.009","article-title":"Trichoscopy in Hair Shaft Disorders","volume":"36","author":"Rudnicka","year":"2018","journal-title":"Dermatol. Clin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000369402","article-title":"Scalp dermoscopy or trichoscopy","volume":"47","author":"Lacarrubba","year":"2015","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_17","first-page":"867","article-title":"Hair and scalp evaluation: The trichogram","volume":"104","year":"2013","journal-title":"Actas Dermosifiliogr."},{"key":"ref_18","first-page":"37","article-title":"Zastosowanie badania trichoskopowego w diagnostyce chor\u00f3b w\u0142os\u00f3w","volume":"2","author":"Rakowska","year":"2007","journal-title":"Dermatologica"},{"key":"ref_19","first-page":"247","article-title":"Post\u0119py w diagnostyce \u0142ysienia","volume":"96","author":"Olszewska","year":"2009","journal-title":"Przeg. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3315\/jdcr.2008.1021","article-title":"Trichoscopy (hair and scalp videodermoscopy) in the healthy female. Method standardization and norms for measurable parameters","volume":"3","author":"Rakowska","year":"2009","journal-title":"J. Dermatol. Case Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1586\/17469872.1.6.769","article-title":"Presence and future of dermoscopy","volume":"1","author":"Rudnicka","year":"2006","journal-title":"Expert Rev. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/jmg.2008.058743","article-title":"Trichothiodystrophy: A systematic review of 112 published cases characterises a wide spectrum of clinical manifestations","volume":"45","author":"Faghri","year":"2008","journal-title":"J. Med. Genet."},{"key":"ref_23","unstructured":"Zadurska, M. (2011). Oligodontics in the Aspect of Selected Symptoms of Ectodermal Dysplasia, Medical University of Warsaw."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0003-9969(95)00143-3","article-title":"Tooth size in relatives of individuals with oligodontia","volume":"41","author":"Bosman","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/pde.14415","article-title":"Clinical, trichoscopy, and light microscopic findings in hypohidrotic ectodermal dysplasia: Report of 21 patients and a review of the literature","volume":"38","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/978-1-4419-6448-9_10","article-title":"Trichothiodystrophy: Photosensitive, TTD-P, TTD, Tay syndrome","volume":"685","author":"Lambert","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jpeds.2015.04.002","article-title":"Trichoscopic Hair Evaluation in Patients with Ectodermal Dysplasia","volume":"167","author":"Rakowska","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/eos.12071","article-title":"Novel PAX9 mutation associated with syndromic tooth agenesis","volume":"121","author":"Mostowska","year":"2013","journal-title":"Eur. J. Oral Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/bjd.20601","article-title":"WNT10A, dermatology and dentistry","volume":"185","author":"Doolan","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/cge.13714","article-title":"LEF1 haploinsufficiency causes ectodermal dysplasia","volume":"97","author":"Capri","year":"2020","journal-title":"Clin. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/cge.13892","article-title":"Tooth agenesis: What do we know is there a connection to cancer?","volume":"99","author":"Bonczek","year":"2021","journal-title":"Clin. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e1555","DOI":"10.1002\/mgg3.1555","article-title":"Missense mutations in EDA and EDAR genes cause dominant syndromic tooth agenesis","volume":"9","author":"Andreoni","year":"2021","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/0022034508328627","article-title":"EDA gene mutations underlie non-syndromic oligodontia","volume":"88","author":"Song","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e2275","DOI":"10.1002\/mgg3.2275","article-title":"New observation of severe tooth malformation in a female patient with ectodermal dysplasia due to the EDA splice acceptor variant c.742-2A>G","volume":"11","author":"Reinhold","year":"2023","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ajmg.a.61045","article-title":"Ectodermal Dysplasias: Classification and Organization by Phenotype, Genotype, and Molecular Pathway","volume":"179","author":"Wright","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/ajmg.a.32826","article-title":"Pathologic changes of skin and hair in ankyloblepharon-ectodermal defects-cleft lip\/palate (AEC) syndrome","volume":"149A","author":"Dishop","year":"2009","journal-title":"Am. J. Med. Genet. A"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/9\/945\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:37:24Z","timestamp":1760107044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/9\/945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["diagnostics14090945"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14090945","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,4,30]]}}}