{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:37:20Z","timestamp":1777394240665,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVICTOR BABES\u201d UNIVERSITY OF MEDICINE AND PHARMACY TIMISOARA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Breast cancer stands as the primary cause of cancer-related mortality among women worldwide, often presenting with distant metastases upon diagnosis. Ovarian metastases originating from breast cancer represent a range of 3\u201330% of all ovarian neoplasms. Case Report: Herein, we present the histopathological, histochemical, and immunohistochemical findings of a rare case involving mucin-producing lobular breast carcinoma metastasizing to an ovarian fibroma in an 82-year-old female previously diagnosed with lobular breast carcinoma. Histopathological examination of the excised tissues revealed a biphasic neoplasm characterized by tumor cells expressing AE-1\/AE-3 cytokeratin, mammaglobin, GCDFP-15, inhibin, and calretinin. Positive mucin staining was observed using histochemical techniques, and reticulin fibers were demonstrated using the Gordon\u2013Sweets technique. A final diagnosis of mucin-producing lobular breast carcinoma metastatic to a benign ovarian fibroma was rendered. Conclusion: The occurrence of metastatic breast carcinoma overlaid on an ovarian tumor represents a rare and diagnostically challenging scenario.<\/jats:p>","DOI":"10.3390\/diagnostics14090953","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:39:42Z","timestamp":1714649982000},"page":"953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Alexandra Corina","family":"Faur","sequence":"first","affiliation":[{"name":"Department I, Discipline of Anatomy and Embryology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-4080","authenticated-orcid":false,"given":"Camelia Vidi\u0163a","family":"Gurban","sequence":"additional","affiliation":[{"name":"Department IV Biochemistry and Pharmacology, Discipline of Biochemistry, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ecaterina","family":"D\u0103escu","sequence":"additional","affiliation":[{"name":"Department I, Discipline of Anatomy and Embryology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u0103zvan Vlad","family":"T\u00eerziu","sequence":"additional","affiliation":[{"name":"Department IX, Surgery I, Discipline of Surgical Semiology I and Thoracic Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Cornelia","family":"Laz\u0103r","sequence":"additional","affiliation":[{"name":"Department V Internal Medicine I, Discipline of Internal Medicine IV, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-5438","authenticated-orcid":false,"given":"Laura Andreea","family":"Ghenciu","sequence":"additional","affiliation":[{"name":"Department III, Discipline of Pathophysiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/cncr.24807","article-title":"Ovarian metastases from breast cancer: Report of 29 cases","volume":"116","author":"Bigorie","year":"2010","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3892\/mco.2021.2297","article-title":"Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: A case report","volume":"15","author":"Akizawa","year":"2021","journal-title":"Mol. 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