{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:49Z","timestamp":1787027929681,"version":"build-2736575974"},"reference-count":18,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP19678106"],"award-info":[{"award-number":["AP19678106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Arteriovenous malformations (AVMs) are abnormal tangles of arteries and veins that connect directly without an intervening capillary bed. Epileptic seizures are the second most common symptom in patients with brain AVMs, occurring in 30 to 50% of cases. However, the exact mechanism of epileptic seizure development in AVMs remains unclear. In this study, we aimed to investigate the factors associated with epileptic seizures in patients with brain arteriovenous malformation (AVMs) in Kazakhstan. Methods: A case\u2013control study was conducted, which included 163 patients diagnosed with brain AVMs. Demographic and clinical data were collected and analyzed, and multivariate logistic regression was built to assess the factors associated with seizures in brain AVMs. Results: from this rupture of vessels OR = 0.36 95% CI (0.14\u20130.91, a medium-to-high Spetzler-Martin score (III\u2013V) OR = 6.16 (2.14\u201317.69) and OR = 3.05 (1.08\u20138.68), respectively), location in brain cortex (frontal lobe OR = 6.16 (2.04\u201318.54), parietal lobe OR = 9.37 (3.26\u201326.91), temporal lobe OR = 4.57 (1.56\u201313.36), occipital lobe OR = 0.27 (0.08\u20130.91), and the presence of hemiparesis OR = 0.12 (0.02\u20130.66) in adverse outcomes were statistically significantly associated with the presence of epileptic seizures in brain arteriovenous malformations patients. Conclusions: To conclude, this contributed to model factors associated with brain arteriovenous malformations that are linked to epileptic seizures.<\/jats:p>","DOI":"10.3390\/diagnostics14111077","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:54:09Z","timestamp":1716360849000},"page":"1077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations of Brain Arteriovenous Malformation-Related Factors with Epileptic Seizure Presentations"],"prefix":"10.3390","volume":"14","author":[{"given":"Kymbat","family":"Mukhtarova","sequence":"first","affiliation":[{"name":"National Center for Biotechnology, 13\/5, Kurgalzhynskoye Road, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-7980","authenticated-orcid":false,"given":"Chingiz","family":"Nurimanov","sequence":"additional","affiliation":[{"name":"Department of Vascular and Functional Neurosurgery, National Center for Neurosurgery, 34\/1 Turan Avenue, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9677-008X","authenticated-orcid":false,"given":"Elena","family":"Zholdybayeva","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology, 13\/5, Kurgalzhynskoye Road, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerbol","family":"Makhambetov","sequence":"additional","affiliation":[{"name":"Department of Vascular and Functional Neurosurgery, National Center for Neurosurgery, 34\/1 Turan Avenue, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serik","family":"Akshulakov","sequence":"additional","affiliation":[{"name":"Department of Vascular and Functional Neurosurgery, National Center for Neurosurgery, 34\/1 Turan Avenue, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.wneu.2015.04.064","article-title":"Cerebral Arteriovenous Malformations and Epilepsy, Part 2: Predictors of Seizure Outcomes Following Radiosurgery","volume":"84","author":"Ding","year":"2015","journal-title":"World Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.wneu.2021.10.114","article-title":"Molecular Signature of Brain Arteriovenous Malformation Hemorrhage: A Systematic Review","volume":"157","author":"Germans","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neurol.2022.05.011","article-title":"New approaches for brain arteriovenous malformations-related epilepsy","volume":"179","author":"Bustuchina","year":"2023","journal-title":"Rev. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"570198","DOI":"10.3389\/fneur.2020.570198","article-title":"Single-Stage Combined Embolization and Resection for Spetzler-Martin Grade III\/IV\/V Arteriovenous Malformations: A Single-Center Experience and Literature Review","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1528-1157.1986.tb03539.x","article-title":"Cerebral Arteriovenous Malformations and Epilepsy: Factors in the Development of Epilepsy","volume":"27","author":"Crawford","year":"1986","journal-title":"Epilepsia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.0b013e3182494d40","article-title":"Epileptic seizures at initial presentation in patients with brain arteriovenous malformation","volume":"78","author":"Garcin","year":"2012","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1177\/197140091102400610","article-title":"Characteristics of Brain Arteriovenous Malformations Presenting with Seizures without Acute or Remote Hemorrhage","volume":"24","author":"Jiang","year":"2011","journal-title":"Neuroradiol. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3171\/jns.1986.65.4.0476","article-title":"A proposed grading system for arteriovenous malformations","volume":"65","author":"Spetzler","year":"1986","journal-title":"J. Neurosurg."},{"key":"ref_9","first-page":"345","article-title":"Epilepsy associated with cerebral arteriovenous malformations: A multivariate analysis of angioarchitectural characteristics","volume":"16","author":"Turjman","year":"1995","journal-title":"Am. J. Neuroradiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00006123-200208000-00004","article-title":"Results of multimodality treatment for 141 patients with brain arteriovenous malformations and seizures: Factors associated with seizure incidence and seizure outcomes","volume":"51","author":"Hoh","year":"2002","journal-title":"Neurosurgery"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3171\/2012.3.JNS111575","article-title":"Multimodality management of Spetzler-Martin Grade III arteriovenous malformations","volume":"116","author":"Pandey","year":"2012","journal-title":"J. Neurosurg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/2022.4.FOCUS22117","article-title":"More pronounced hemodynamic alterations in patients with brain arteriovenous malformation\u2013associated epilepsy","volume":"53","author":"Germans","year":"2022","journal-title":"Neurosurg. Focus"},{"key":"ref_13","first-page":"e000442","article-title":"Increase in Ruptured Cerebral Arteriovenous Malformations and Mortality in the United States: Unintended Consequences of the ARUBA Trial?","volume":"3","author":"Dicpinigaitis","year":"2022","journal-title":"Stroke Vasc. Int. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00062-021-01119-w","article-title":"Benefits from Exclusion Treatment of Unruptured Brain Arteriovenous Malformations on Epilepsy in Adults","volume":"32","author":"Capocci","year":"2022","journal-title":"Clin. Neuroradiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e634","DOI":"10.1016\/j.wneu.2019.02.104","article-title":"Seizure Presentation in Patients with Brain Arteriovenous Malformations Treated with Stereotactic Radiosurgery: A Multicenter Study","volume":"126","author":"Chen","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/jnnp-2013-305123","article-title":"Brain arteriovenous malformations and seizures: An Italian study","volume":"85","author":"Galletti","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_17","unstructured":"Bokhari, M.R., and Bokhari, S.R.A. (2024). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2022.4.FOCUS2288","article-title":"De Novo epilepsy after microsurgical resection of brain arteriovenous malformations","volume":"53","author":"Sen","year":"2022","journal-title":"Neurosurg. Focus"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/11\/1077\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:46:20Z","timestamp":1760107580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/11\/1077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":18,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["diagnostics14111077"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14111077","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]}}}