{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:21:42Z","timestamp":1776738102445,"version":"3.51.2"},"reference-count":47,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Health"},{"name":"Kurt Goldstein Institut"},{"name":"AstraZeneca"},{"name":"Dresden International University"},{"name":"Thieme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Peritoneal dialysis-related peritonitis (PDRP) is the most common complication of peritoneal dialysis (PD), which can lead to poor outcomes if not diagnosed and treated early. We aimed to investigate the diagnostic accuracy of MMP-8 and IL-6-based point-of-care tests (POCTs) in diagnosing PDRP in PD patients. Methods: This retrospective chart review study was conducted at a comprehensive kidney center in Qatar. It involved all adult PD patients who underwent PDRP from July 2018 to October 2019 and for whom MMP-8 and IL-6-based POCTs were used to diagnose presumptive peritonitis. Measures of diagnostic accuracy were computed. Peritoneal fluid effluent analysis was the reference standard. Results: We included 120 patients (68 [56.7%] females, ages 55.6 \u00b1 15.6 years, treatment duration 39.5 \u00b1 30.4 months [range: 5\u2013142 months]). In this population, MMP-8 and IL-6-based POCTs yielded 100% in all dimensions of diagnostic accuracy (sensitivity, specificity, positive and negative predictive values). Conclusions: MMP-8 and IL-6-based POCTs might be helpful in the early detection of PDRP. This monocentric observation requires further confirmation in a prospective multicentric setting.<\/jats:p>","DOI":"10.3390\/diagnostics14111113","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T03:48:49Z","timestamp":1716868129000},"page":"1113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Accuracy of MMP-8 and IL-6-Based Point-of-Care Testing to Detect Peritoneal Dialysis-Related Peritonitis: A Single-Center Experience"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-3746","authenticated-orcid":false,"given":"Rania","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis Division, Fahad Bin Jassim Kidney Center, Hamad General Hospital, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"},{"name":"Division of Health Care Sciences, Dresden International University, Freiberger Str. 37, 01067 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mido Max","family":"Hijazi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Division of Spine Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Fetscherstrasse 74, 01307 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadwa","family":"AlAli","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis Division, Fahad Bin Jassim Kidney Center, Hamad General Hospital, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-7686","authenticated-orcid":false,"given":"Abdullah","family":"Hamad","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis Division, Fahad Bin Jassim Kidney Center, Hamad General Hospital, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlam","family":"Bushra","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis Division, Fahad Bin Jassim Kidney Center, Hamad General Hospital, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4697-6223","authenticated-orcid":false,"given":"Lutz","family":"Mirow","sequence":"additional","affiliation":[{"name":"Department of Surgery, Klinikum Chemnitz gGmbH, Medical Faculty and University Hospital Carl Gustav Carus, Medical Campus Chemnitz, Technische Universit\u00e4t Dresden, Flemmingstra\u00dfe 2, 09116 Chemnitz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-5904","authenticated-orcid":false,"given":"Timo","family":"Siepmann","sequence":"additional","affiliation":[{"name":"Division of Health Care Sciences, Dresden International University, Freiberger Str. 37, 01067 Dresden, Germany"},{"name":"Department of Neurology, Technische Universit\u00e4t Dresden, Medical Faculty and University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2147\/IJNRD.S50527","article-title":"Evaluating the benefits of home-based peritoneal dialysis","volume":"7","author":"Bargman","year":"2014","journal-title":"Int. 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