{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:17:34Z","timestamp":1773724654988,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The severity of pulpitis is a crucial factor in determining the suitable treatment. There are no clear objective indicators to assess the stage of pulp inflammation that could be used in clinical practice. The change in blood pH of the pulp during the inflammatory phase could hypothetically serve as an indicator of the pulp inflammation severity. The aim of this study was to assess the pH values in the pulpal blood of mature teeth in patients with symptomatic pulpitis, in comparison with the healthy controls. The study included patients with symptoms of pulpitis in premolar or molar teeth (Test group; n = 24, mean age 36.04, SD 7.10), and healthy controls (Control group, n = 6, mean age 24.5, SD 5.94) referred for extraction of premolars or third molars, for orthodontic reasons. The pulpal blood was taken at the opening of the endodontic access cavity, and the pH value was measured in both groups. Statistical analysis was performed using the SPSS 27.0 program with a significance level of p \u2264 0.05. The Mann\u2013Whitney test for dependent samples was performed to evaluate the statistical difference between the groups. The patients with symptomatic pulpitis had significantly decreased pulpal blood pH compared to the healthy controls (p \u2264 0.05). The mean pulpal blood pH was 7.27 (SD 0.06) and 7.40 (SD 0.02) in Test and Control groups, respectively. In the Test group, the pulpal blood pH values were significantly lower in the patients who had symptoms for 3 days or more (7.25, SD 0.05) than in those who had symptoms for up to 3 days (7.33, SD 0.03) (p &lt; 0.001). The pH value of the pulpal blood gradually declines in cases of symptomatic pulpitis, along with increasing duration of the symptoms.<\/jats:p>","DOI":"10.3390\/diagnostics14111128","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T06:58:07Z","timestamp":1716965887000},"page":"1128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blood pH Changes in Dental Pulp of Patients with Pulpitis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9585-8272","authenticated-orcid":false,"given":"Pedram","family":"Hosseinzadehfard","sequence":"first","affiliation":[{"name":"Department of Dental & Oral Pathology, Faculty of Odontology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu g.2, 50009 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neringa","family":"Sku\u010dait\u0117","sequence":"additional","affiliation":[{"name":"Department of Dental & Oral Pathology, Faculty of Odontology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu g.2, 50009 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-3221","authenticated-orcid":false,"given":"Vita","family":"Maciulskiene-Visockiene","sequence":"additional","affiliation":[{"name":"Department of Dental & Oral Pathology, Faculty of Odontology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu g.2, 50009 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-3589","authenticated-orcid":false,"given":"Greta","family":"Lodiene","sequence":"additional","affiliation":[{"name":"Department of Dental & Oral Pathology, Faculty of Odontology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu g.2, 50009 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0003-9969(91)90077-8","article-title":"Microbiological studies of carious dentine from human teeth with irreversible pulpitis","volume":"36","author":"Hahn","year":"1991","journal-title":"Arch. 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