{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:41:13Z","timestamp":1762540873247,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The benefit of prophylactic implantable cardioverter defibrillators (ICDs) in patients with severe systolic dysfunction of non-ischemic origin is still unclear, and the identification of patients at risk for sudden cardiac death remains a major challenge. Aims\/Methods: We retrospectively reviewed all consecutive patients with non-ischemic dilated cardiomyopathy (NICM) who underwent prophylactic ICD implantation between 2008 and 2020 in two tertiary centers. Our main goal was to identify the predictors of appropriate ICD therapies (anti-tachycardia pacing [ATP] and\/or shocks) in this cohort of patients. Results: A total of 224 patients were included. After a median follow-up of 51 months, 61 patients (27.2%) required appropriate ICD therapies. Patients with appropriate ICD therapies were more frequently men (87% vs. 69%, p = 0.006), of younger age (59 years, (53\u201365) vs. 64 years, (57\u201370); p = 0.02), showed more right bundle branch blocks (RBBBs) (15% vs. 4%, p = 0.007) and less left bundle branch blocks (LBBBs) (26% vs. 47%, p = 0.005) in the ECG, and had higher left ventricular end-diastolic (100 mL\/m2, (90\u2013117) vs. 86, (71\u2013110); p = 0.011) and systolic volumes (72 mL\/m2, (59\u201387) vs. 61, (47\u201381), p = 0.05). In a multivariate competing-risks regression analysis, RBBB (HR 2.26, CI 95% 1.02\u20134.98, p = 0.043) was identified as an independent predictor of appropriate ICD therapies. Conclusion: RBBBs may help to identify patients with NICM at high risk of ventricular arrhythmias and requiring ICD intervention.<\/jats:p>","DOI":"10.3390\/diagnostics14111173","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T03:51:45Z","timestamp":1717386705000},"page":"1173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Right Bundle Branch Block Predicts Appropriate Implantable Cardioverter Defibrillator Therapies in Patients with Non-Ischemic Dilated Cardiomyopathy and a Prophylactic Implantable Cardioverter Defibrillator"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-8285","authenticated-orcid":false,"given":"Marta","family":"Jim\u00e9nez-Blanco Bravo","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Vieno km 9100, 28034 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Cardiovascular en Red (CIBER-CV), Avenida Monforte de Lemos 3\u20135, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-8526","authenticated-orcid":false,"given":"Gonzalo Luis","family":"Alonso Salinas","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario de Navarra (HUN-NOU), Calle de Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"Navarrabiomed (Miguel Servet Foundation), IdiSNA, 31008 Pamplona, Spain"},{"name":"Heath Sciences Department, Universidad P\u00fablica de Navarra (UPNA-NUP), 31006 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Parra Esteban","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Puerta de Hierro, Calle Joaqu\u00edn Rodrigo 1, Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-9064","authenticated-orcid":false,"given":"Jorge","family":"Toquero Ramos","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cardiovascular en Red (CIBER-CV), Avenida Monforte de Lemos 3\u20135, 28029 Madrid, Spain"},{"name":"Cardiology Department, Hospital Universitario Puerta de Hierro, Calle Joaqu\u00edn Rodrigo 1, Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Amores Luque","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Vieno km 9100, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Zamorano G\u00f3mez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Vieno km 9100, 28034 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Cardiovascular en Red (CIBER-CV), Avenida Monforte de Lemos 3\u20135, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eusebio","family":"Garc\u00eda-Izquierdo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Puerta de Hierro, Calle Joaqu\u00edn Rodrigo 1, Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-6446","authenticated-orcid":false,"given":"Jes\u00fas","family":"\u00c1lvarez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Ram\u00f3n y Cajal, Carretera de Colmenar Vieno km 9100, 28034 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Cardiovascular en Red (CIBER-CV), Avenida Monforte de Lemos 3\u20135, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Fern\u00e1ndez Lozano","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cardiovascular en Red (CIBER-CV), Avenida Monforte de Lemos 3\u20135, 28029 Madrid, Spain"},{"name":"Cardiology Department, Hospital Universitario Puerta de Hierro, Calle Joaqu\u00edn Rodrigo 1, Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Castro Urda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cardiovascular en Red (CIBER-CV), Avenida Monforte de Lemos 3\u20135, 28029 Madrid, Spain"},{"name":"Cardiology Department, Hospital Universitario Puerta de Hierro, Calle Joaqu\u00edn Rodrigo 1, Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJMoa1609758","article-title":"Declining Risk of Sudden Death in Heart Failure","volume":"377","author":"Shen","year":"2017","journal-title":"N. 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