{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T23:51:47Z","timestamp":1788652307858,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NSR Hospitals"},{"name":"Danish Cancer Plan 4"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Malignant pleural effusion (MPE) affects up to 15% of patients with malignancy, and the prevalence is increasing. Non-expandable lung (NEL) complicates MPE in up to 30% of cases. However, it is not known if patients with malignant pleural effusion and NEL are more symptomatic in activities of daily living compared to patients with MPE with expandable lung. Methods: This was an observational study on consecutively recruited patients with MPE from our pleural clinic. Before thoracentesis, patients completed patient-reported outcomes on cancer symptoms (ESAS), health-related quality of life (5Q-5D-5L), and dyspnoea scores. Following thoracentesis, patients scored dyspnoea relief and symptoms during thoracentesis. Data on focused lung ultrasound and pleural effusion biochemistry were collected. The non-expandable lung diagnosis was made by pleural experts based on radiological and clinical information. Results: We recruited 43 patients, including 12 with NEL (28%). The NEL cohort resembled those from previous studies concerning ultrasonography, pleural fluid biochemistry, and fewer cases with high volume thoracentesis. Patients with and without NEL were comparable concerning baseline demography. The 5Q-5D-5L utility scores were 0.836 (0.691\u20130.906) and 0.806 (0.409\u20130.866), respectively, for patients with and without NEL. We observed no between-group differences in symptom burden or health-related quality of life. Conclusion: While the presence of NEL affects the clinical management of recurrent MPE, the presence of NEL seems not to affect patients\u2019 overall symptom burden in patients with MPE.<\/jats:p>","DOI":"10.3390\/diagnostics14111176","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T03:51:45Z","timestamp":1717386705000},"page":"1176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patient-Reported Outcome Measures in Patients with and without Non-Expandable Lung Secondary to Malignant Pleural Effusion\u2014A Single-Centre Observational Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-9929","authenticated-orcid":false,"given":"Jesper Koefod","family":"Petersen","sequence":"first","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-6297","authenticated-orcid":false,"given":"Katrine","family":"Fjaellegaard","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Bech","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Alstrup","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn","family":"H\u00f8egholm","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatinder Sing","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Odense University Hospital, 2900 Hellerup, Denmark"},{"name":"Academic Respiratory Unit, University of Bristol, Bristol BS8 1TU, UK"},{"name":"Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Frost","family":"Clementsen","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"},{"name":"Copenhagen Academy for Medical Education and Simulation (CAMES), Rigshospitalet, University of Copenhagen and the Capital Region of Denmark, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian B.","family":"Laursen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Odense University Hospital, 2900 Hellerup, Denmark"},{"name":"Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1231-9209","authenticated-orcid":false,"given":"Uffe","family":"Bodtger","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit PLUZ, Department of Internal and Respiratory Medicine, Zealand University Hospitals, Roskilde and N\u00e6stved, 4000 Roskilde, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/resp.12496","article-title":"Clinical features and survival of lung cancer patients with pleural effusions","volume":"20","author":"Porcel","year":"2015","journal-title":"Respirology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1801254","DOI":"10.1183\/13993003.01254-2018","article-title":"Investigating unilateral pleural effusions: The role of cytology","volume":"52","author":"Arnold","year":"2018","journal-title":"Eur. 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