{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:50:13Z","timestamp":1792615813835,"version":"4.5.0"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Non-ischemic dilated cardiomyopathy (DCM) represents a significant cause of heart failure, defined as the presence of left ventricular (LV) dilatation and systolic dysfunction unexplained solely by abnormal loading conditions or coronary artery disease. Cardiac resynchronization therapy (CRT) has emerged as a cornerstone in the management of heart failure, particularly in patients with DCM. However, identifying patients who will benefit the most from CRT remains challenging. Speckle tracking echocardiography (STE) has garnered attention as a non-invasive imaging modality that allows for the quantitative assessment of myocardial mechanics, offering insights into LV function beyond traditional echocardiographic parameters. This comprehensive review explores the role of STE in guiding patient selection and optimizing outcomes in CRT for DCM. By assessing parameters such as LV strain, strain rate, and dyssynchrony, STE enables a more precise evaluation of myocardial function and mechanical dyssynchrony, aiding in the identification of patients who are most likely to benefit from CRT. Furthermore, STE provides valuable prognostic information and facilitates post-CRT optimization by guiding lead placement and assessing response to therapy. Through an integration of STE with CRT, clinicians can enhance patient selection, improve procedural success rates, and ultimately, optimize clinical outcomes in patients with DCM. This review underscores the pivotal role of STE in advancing personalized management strategies for DCM patients undergoing CRT.<\/jats:p>","DOI":"10.3390\/diagnostics14111178","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T08:19:42Z","timestamp":1717402782000},"page":"1178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Speckle Tracking Echocardiography in Patients with Non-Ischemic Dilated Cardiomyopathy Who Undergo Cardiac Resynchronization Therapy: A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Nikolaos","family":"Antoniou","sequence":"first","affiliation":[{"name":"Cardiology Department, General Hospital G. Papanikolaou, 57010 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5600-7454","authenticated-orcid":false,"given":"Maria","family":"Kalaitzoglou","sequence":"additional","affiliation":[{"name":"Cardiology Department, General Hospital G. Papanikolaou, 57010 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamprini","family":"Tsigkriki","sequence":"additional","affiliation":[{"name":"Cardiology Department, General Hospital G. Papanikolaou, 57010 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0182-8259","authenticated-orcid":false,"given":"Amalia","family":"Baroutidou","sequence":"additional","affiliation":[{"name":"Cardiology Department, AHEPA University General Hospital, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Tsaousidis","sequence":"additional","affiliation":[{"name":"Cardiology Department, General Hospital G. Papanikolaou, 57010 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Koulaouzidis","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-6319","authenticated-orcid":false,"given":"George","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"Cardiology Department, AHEPA University General Hospital, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-7867","authenticated-orcid":false,"given":"Dafni","family":"Charisopoulou","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ejhf.1461","article-title":"Heart failure in cardiomyopathies: A position paper from the Heart Failure Association of the European Society of Cardiology","volume":"21","author":"Seferovic","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/eurheartj\/ehv727","article-title":"Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: A position statement of the ESC working group on myocardial and pericardial diseases","volume":"37","author":"Pinto","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijcard.2010.01.011","article-title":"Heart failure etiology impacts survival of patients with heart failure","volume":"149","author":"Pecini","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.21037\/cdt-20-302","article-title":"Pathophysiology of heart failure","volume":"11","author":"Schwinger","year":"2021","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","article-title":"Epidemiology and aetiology of heart failure","volume":"13","author":"Ziaeian","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.23736\/S2724-5683.21.05736-7","article-title":"Contemporary etiology and prognosis of dilated non-ischemic cardiomyopathy","volume":"70","author":"Manca","year":"2022","journal-title":"Minerva Cardiol. Angiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jtcvs.2012.10.001","article-title":"Updated guidelines for device-based therapy of cardiac rhythm abnormalities","volume":"144","author":"Gillinov","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1007\/s12350-019-01758-0","article-title":"Mechanical dyssynchrony: How do we measure it, what it means, and what we can do about it","volume":"28","author":"Fudim","year":"2021","journal-title":"J. Nucl. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/HCO.0000000000000314","article-title":"Mechanical dyssynchrony in patients with heart failure and reduced ejection fraction: How to measure?","volume":"31","author":"Khidir","year":"2016","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/CIRCULATIONAHA.107.743120","article-title":"Results of the Predictors of Response to CRT (PROSPECT) trial","volume":"117","author":"Chung","year":"2008","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","article-title":"Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms","volume":"52","author":"Linde","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","article-title":"Cardiac resynchronization therapy for mild-to-moderate heart failure","volume":"363","author":"Tang","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_16","first-page":"1463","article-title":"Avoiding non-responders to cardiac resynchronization therapy: A practical guide","volume":"38","author":"Daubert","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1161\/CIRCULATIONAHA.112.000112","article-title":"Cardiac resynchronization therapy: State-of-the-art of current applications, guidelines, ongoing trials, and areas of controversy","volume":"128","author":"Prinzen","year":"2013","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.hlc.2019.03.012","article-title":"Echocardiographic Strain in Clinical Practice","volume":"28","author":"Trivedi","year":"2019","journal-title":"Heart Lung Circ."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/ehjci\/jez041","article-title":"Myocardial strain imaging: Review of general principles, validation, and sources of discrepancies","volume":"20","author":"Amzulescu","year":"2019","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mayocp.2018.07.017","article-title":"Echocardiographic Assessment of Left Ventricular Systolic Function: An Overview of Contemporary Techniques, Including Speckle-Tracking Echocardiography","volume":"94","author":"Luis","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s11845-022-03210-8","article-title":"Myocardial strain: A clinical review","volume":"192","author":"Brady","year":"2023","journal-title":"Ir. J. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.21037\/cdt.2017.06.01","article-title":"Three-dimensional speckle-tracking echocardiography: Benefits and limitations of integrating myocardial mechanics with three-dimensional imaging","volume":"8","author":"Muraru","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijcard.2014.07.015","article-title":"Three-dimensional speckle strain echocardiography is more accurate and efficient than 2D strain in the evaluation of left ventricular function","volume":"176","author":"Xu","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.echo.2008.12.003","article-title":"Left ventricular strain patterns in dilated cardiomyopathy predict response to cardiac resynchronization therapy: Timing is not everything","volume":"22","author":"Carasso","year":"2009","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jcmg.2008.12.022","article-title":"Opposing wall mechanics are significantly influenced by longitudinal cardiac rotation in the assessment of ventricular dyssynchrony","volume":"2","author":"Phillips","year":"2009","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/eurjhf\/hfp032","article-title":"Comparison of myocardial deformation and velocity dyssynchrony for identification of responders to cardiac resynchronization therapy","volume":"11","author":"Mele","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"ref_27","first-page":"552","article-title":"Optimization of cardiac resynchronization therapy based on speckle tracking","volume":"120","author":"Sipula","year":"2019","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/echo.14425","article-title":"2D\/3D Echocardiographic features of patients with reverse remodeling after cardiac resynchronization therapy","volume":"36","author":"Cimino","year":"2019","journal-title":"Echocardiography"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pescariu, S.A., \u015eo\u015fdean, R., Tudoran, C., Ionac, A., Pop, G.N., Timar, R.Z., Pescariu, S., and Tudoran, M. (2021). Echocardiographic Parameters as Predictors for the Efficiency of Resynchronization Therapy in Patients with Dilated Cardiomyopathy and HFrEF. Diagnostics, 12.","DOI":"10.3390\/diagnostics12010035"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gurgu, A., Luca, C.T., Vacarescu, C., Petrescu, L., Goanta, E.V., Lazar, M.A., Arn\u0103utu, D.A., and Cozma, D. (2023). Considering Diastolic Dyssynchrony as a Predictor of Favorable Response in LV-Only Fusion Pacing Cardiac Resynchronization Therapy. Diagnostics, 13.","DOI":"10.3390\/diagnostics13061186"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1540-8159.2009.02434.x","article-title":"Right ventricular myocardial function in patients with either idiopathic or ischemic dilated cardiomyopathy without clinical sign of right heart failure: Effects of cardiac resynchronization therapy","volume":"32","author":"Salerno","year":"2009","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cardfail.2010.12.004","article-title":"Additive value of right ventricular dyssynchrony indexes in predicting the success of cardiac resynchronization therapy: A speckle-tracking imaging study","volume":"17","author":"Vitarelli","year":"2011","journal-title":"J. Card. Fail."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.amjcard.2011.06.052","article-title":"Relation between left ventricular morphology and reduction in functional mitral regurgitation by cardiac resynchronization therapy in patients with idiopathic dilated cardiomyopathy","volume":"108","author":"Matsumoto","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/AC.67.4.2170683","article-title":"Three-dimensional speckle tracking echocardiography for the assessment of left ventricular function and mechanical dyssynchrony","volume":"67","author":"Kang","year":"2012","journal-title":"Acta Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jacc.2011.12.030","article-title":"Targeted left ventricular lead placement to guide cardiac resynchronization therapy: The TARGET study: A randomized, controlled trial","volume":"59","author":"Khan","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCHEARTFAILURE.112.000078","article-title":"Echocardiography-guided left ventricular lead placement for cardiac resynchronization therapy: Results of the Speckle Tracking Assisted Resynchronization Therapy for Electrode Region trial","volume":"6","author":"Saba","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1093\/eurheartj\/ehm443","article-title":"Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: A two-dimensional speckle strain study","volume":"28","author":"Caso","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jchf.2019.02.015","article-title":"Outcomes and effect of treatment according to etiology in HFrEF: An analysis of PARADIGM-HF","volume":"7","author":"Balmforth","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/ejhf.1914","article-title":"Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy","volume":"22","author":"Merlo","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ejhf.1103","article-title":"Evolving concepts in dilated cardiomyopathy","volume":"20","author":"Merlo","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"ref_41","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jacc.2012.12.017","article-title":"ACCF\/HRS\/AHA\/ASE\/HFSA\/SCAI\/SCCT\/SCMR 2013 appropriate use criteria for implantable cardioverter\u2013defibrillators and cardiac resynchronization therapy: A report of the American College of Cardiology Foundation appropriate use criteria task force, Heart Rhythm Society, American Heart Association, American Society of Echocardiography, Heart Failure Society of America, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance","volume":"61","author":"Russo","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aogh.2013.12.003","article-title":"Cardiac resynchronization therapy: Who benefits?","volume":"80","author":"Chinitz","year":"2014","journal-title":"Ann. Glob. Health"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e271","DOI":"10.1016\/S2589-7500(19)30123-2","article-title":"A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: A systematic review and meta-analysis","volume":"1","author":"Liu","year":"2019","journal-title":"Lancet Digit. Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41591-018-0300-7","article-title":"High-performance medicine: The convergence of human and artificial intelligence","volume":"25","author":"Topol","year":"2019","journal-title":"Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10741-023-10357-8","article-title":"Artificial intelligence models in prediction of response to cardiac resynchronization therapy: A systematic review","volume":"29","author":"Nazar","year":"2024","journal-title":"Heart Fail. Rev."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/11\/1178\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:53:00Z","timestamp":1760107980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/11\/1178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,3]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["diagnostics14111178"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14111178","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,3]]}}}